Published in J Biol Chem on July 03, 2003
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J (2008) 6.32
Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov (2011) 4.05
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol (2013) 3.11
Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03
Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell (2013) 2.79
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68
Targeting protein prenylation for cancer therapy. Nat Rev Cancer (2011) 2.60
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
The tuberous sclerosis complex. Ann N Y Acad Sci (2010) 2.51
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol (2004) 2.37
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J (2007) 2.27
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors. J Cell Biol (2004) 2.27
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene (2009) 2.14
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A (2006) 2.06
Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A (2008) 1.97
Lymphangioleiomyomatosis - a wolf in sheep's clothing. J Clin Invest (2012) 1.87
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem (2009) 1.67
Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev (2008) 1.60
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2008) 1.57
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol (2005) 1.56
Regulation of mTORC1 by PI3K signaling. Trends Cell Biol (2015) 1.54
The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci (2009) 1.48
Sustained effects of sirolimus on lung function and cystic lung lesions in lymphangioleiomyomatosis. Am J Respir Crit Care Med (2014) 1.48
Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol (2006) 1.48
Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol (2006) 1.47
Emerging role of autophagy in kidney function, diseases and aging. Autophagy (2012) 1.43
PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects. Cell Cycle (2009) 1.38
Targeting protein lipidation in disease. Trends Mol Med (2012) 1.37
mTORC2 is required for proliferation and survival of TSC2-null cells. Mol Cell Biol (2011) 1.36
Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. Genes Dev (2012) 1.30
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Staying alive: metabolic adaptations to quiescence. Cell Cycle (2012) 1.28
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol (2015) 1.27
Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol (2006) 1.24
Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice. Clin Cancer Res (2011) 1.23
Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner. Proc Natl Acad Sci U S A (2011) 1.20
Constitutively active Rheb induces oncogenic transformation. Oncogene (2008) 1.20
The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest (2009) 1.17
Biology and treatment of metastatic gastrointestinal neuroendocrine tumors. Gastrointest Cancer Res (2008) 1.16
Deconvoluting mTOR biology. Cell Cycle (2012) 1.16
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene (2009) 1.14
Phosphatidylinositol 3-kinase: the oncoprotein. Curr Top Microbiol Immunol (2010) 1.14
Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy. J Mammary Gland Biol Neoplasia (2012) 1.14
Regulation of mRNA translation in renal physiology and disease. Am J Physiol Renal Physiol (2009) 1.13
Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. J Biol Chem (2011) 1.12
Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. J Biol Chem (2011) 1.08
Key factors in mTOR regulation. Cell Mol Life Sci (2009) 1.08
Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis. EMBO Mol Med (2011) 1.07
Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol (2007) 1.05
The small GTPase Rheb is a key component linking amino acid signaling and TOR in the nutritional pathway that controls mosquito egg development. Insect Biochem Mol Biol (2010) 1.04
Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Mol Cancer Ther (2009) 1.02
Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. J Biol Chem (2009) 1.02
Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J (2009) 1.02
Hematopoietic cell fate and the initiation of leukemic properties in primitive primary human cells are influenced by Ras activity and farnesyltransferase inhibition. Mol Cell Biol (2004) 1.00
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap. Oncogene (2012) 1.00
Neuronal autophagy and neurodevelopmental disorders. Exp Neurobiol (2013) 0.96
Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas. Blood (2011) 0.95
Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades. J Cell Biochem (2009) 0.94
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. Oncotarget (2015) 0.92
Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies. Respir Med (2010) 0.92
Rheb and mammalian target of rapamycin in mitochondrial homoeostasis. Open Biol (2013) 0.92
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1. J Biol Chem (2007) 0.91
E2F1 regulates cellular growth by mTORC1 signaling. PLoS One (2011) 0.91
Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha36, a variant of ER-alpha. Am J Pathol (2010) 0.91
mTOR signaling in autophagy regulation in the kidney. Semin Nephrol (2013) 0.91
Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR. Methods Enzymol (2008) 0.90
Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis. Int J Biochem Cell Biol (2008) 0.90
Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res (2014) 0.90
AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog (2010) 0.89
In pulmonary lymphangioleiomyomatosis expression of progesterone receptor is frequently higher than that of estrogen receptor. Virchows Arch (2014) 0.88
Targeting Rb inactivation in cancers by synthetic lethality. Am J Cancer Res (2011) 0.87
Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction. Am J Physiol Endocrinol Metab (2014) 0.87
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. J Biol Chem (2013) 0.87
Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation. Blood (2011) 0.87
Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia. J Biol Chem (2010) 0.86
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. Elife (2016) 0.85
Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia. Biologics (2008) 0.85
Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. Mol Cell Biol (2005) 0.85
Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR. Am J Physiol Cell Physiol (2010) 0.84
Local translation of TC10 is required for membrane expansion during axon outgrowth. Nat Commun (2014) 0.84
Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin. J Pharmacol Exp Ther (2011) 0.84
Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors. Nat Protoc (2011) 0.84
Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium. Invest Ophthalmol Vis Sci (2014) 0.82
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. J Biol Chem (2010) 0.82
Expressional Difference of RHEB, HDAC1, and WEE1 Proteins in the Stromal Tumors of the Breast and Their Significance in Tumorigenesis. Korean J Pathol (2012) 0.80
Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro. Autophagy (2012) 0.80
Therapeutic options for lymphangioleiomyomatosis (LAM): where we are and where we are going. F1000 Med Rep (2009) 0.79
Optimizing treatments for lymphangioleiomyomatosis. Expert Rev Respir Med (2012) 0.79
Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood (2007) 0.79
Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation. Am J Physiol Regul Integr Comp Physiol (2014) 0.78
Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer. Small GTPases (2011) 0.77
Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue. Mol Cell Biol (2016) 0.77
Molecular Characterization and Tissue-specific Expression of a Novel FKBP38 Gene in the Cashmere Goat (Capra hircus). Asian-Australas J Anim Sci (2012) 0.77
Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells. Mol Cancer Res (2015) 0.76
The RASSF1A tumor suppressor. J Cell Sci (2007) 2.89
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors. J Cell Biol (2004) 2.27
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem (2002) 2.06
A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog Nucleic Acid Res Mol Biol (2002) 2.01
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. J Biol Chem (2003) 1.77
The RASSF1A tumor suppressor activates Bax via MOAP-1. J Biol Chem (2005) 1.65
Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells. Am J Physiol Cell Physiol (2012) 1.62
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci (2009) 1.58
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability. Cancer Res (2004) 1.53
Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion. Am J Physiol Endocrinol Metab (2011) 1.50
RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. Cancer Res (2004) 1.44
Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem (2007) 1.44
The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. J Biol Chem (2003) 1.43
RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. Cancer Res (2004) 1.40
Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J Immunol (2002) 1.37
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest (2010) 1.29
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane. J Biol Chem (2005) 1.24
Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J Biol Chem (2003) 1.24
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. J Biol Chem (2002) 1.19
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell (2003) 1.18
Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions. Mol Cell Biol (2008) 1.18
AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res (2005) 1.14
NORE1A tumor suppressor candidate modulates p21CIP1 via p53. Cancer Res (2009) 1.13
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol (2006) 1.13
Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). J Biol Chem (2004) 1.12
Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells. Mol Cell Biol (2002) 1.06
E-cadherin dis-engagement activates the Rap1 GTPase. J Cell Biochem (2008) 1.05
Measuring Ras-family GTP levels in vivo--running hot and cold. Methods (2005) 1.03
RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. Cancer Res (2005) 0.99
The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma. Endocr Relat Cancer (2007) 0.98
Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. J Exp Med (2010) 0.97
PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One (2013) 0.96
The Ras effector RASSF2 controls the PAR-4 tumor suppressor. Mol Cell Biol (2010) 0.94
Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin. Curr Drug Targets (2011) 0.91
PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. J Biol Chem (2011) 0.91
Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol (2010) 0.91
Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions. J Biol Chem (2011) 0.90
Rig is a novel Ras-related protein and potential neural tumor suppressor. Proc Natl Acad Sci U S A (2002) 0.90
p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells. Mol Cell Biol (2005) 0.89
Transcriptional regulation of cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin A2 promoter. Cancer Res (2005) 0.89
RASSF1A and the rs2073498 Cancer Associated SNP. Front Oncol (2011) 0.88
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. J Biol Chem (2013) 0.87
Characterization of AND-34 function and signaling. Methods Enzymol (2006) 0.85
Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. Int J Cancer (2008) 0.85
RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells. Epigenetics (2014) 0.84
Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. PLoS One (2013) 0.83
Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. Am J Physiol Renal Physiol (2012) 0.82
RASSF family proteins and Ras transformation. Methods Enzymol (2006) 0.82
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J (2013) 0.81
Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol (2012) 0.81
Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi integrity. Mol Biol Cell (2014) 0.81
Activation of the Ras superfamily of small GTPases. Workshop on exchange factors. EMBO Rep (2003) 0.81
Tamoxifen and the farnesyl transferase inhibitor FTI-277 synergize to inhibit growth in estrogen receptor-positive breast tumor cell lines. Breast Cancer Res Treat (2003) 0.80
Click assembly of magnetic nanovectors for gene delivery. Biomaterials (2011) 0.80
RASSF1A and the Taxol Response in Ovarian Cancer. Mol Biol Int (2012) 0.78
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells. J Cell Biochem (2012) 0.78
Hydrophobic oxime ethers: a versatile class of pDNA and siRNA transfection lipids. ChemMedChem (2011) 0.77
Immunomodulatory effects of Lippia sidoides extract: induction of IL-10 through cAMP and p38 MAPK-dependent mechanisms. J Med Food (2015) 0.75