Published in J Comp Neurol on December 26, 2005
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci (2011) 2.90
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
The coding of temperature in the Drosophila brain. Cell (2011) 2.53
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26
Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13
TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron (2013) 1.95
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol (2008) 1.85
Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci (2007) 1.82
Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons. J Gen Physiol (2007) 1.69
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci (2008) 1.66
TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci (2009) 1.53
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol (2007) 1.51
Nociceptive sensations evoked from 'spots' in the skin by mild cooling and heating. Pain (2008) 1.50
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
The ion channel TRPA1 is required for chronic itch. J Neurosci (2013) 1.41
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci U S A (2008) 1.31
TRPA1 and cold transduction: an unresolved issue? J Gen Physiol (2009) 1.30
TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS One (2012) 1.29
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol (2014) 1.25
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia. Pain (2009) 1.24
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia. J Neurosci Methods (2007) 1.22
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain (2010) 1.22
Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain (2010) 1.22
Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors. Pain (2010) 1.22
TRPV1 and TRPA1 function and modulation are target tissue dependent. J Neurosci (2011) 1.20
Characterization of cold sensitivity and thermal preference using an operant orofacial assay. Mol Pain (2006) 1.17
TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons. PLoS One (2012) 1.14
Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice. Mol Pain (2011) 1.12
Development, plasticity and modulation of visceral afferents. Brain Res Rev (2008) 1.11
Neural control of the lower urinary tract. Compr Physiol (2015) 1.11
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol (2009) 1.09
Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway. J Physiol (2008) 1.08
Normal and abnormal coding of somatosensory stimuli causing pain. Nat Neurosci (2014) 1.08
Menthol suppresses nicotinic acetylcholine receptor functioning in sensory neurons via allosteric modulation. Chem Senses (2012) 1.08
TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur J Neurosci (2010) 1.07
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies. J Biol Chem (2012) 1.06
Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment. Mol Pain (2008) 1.05
TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats. J Physiol (2008) 1.05
Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci (2011) 1.05
Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol (2011) 1.04
Direct evidence for functional TRPV1/TRPA1 heteromers. Pflugers Arch (2014) 1.03
Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Mol Pain (2010) 1.03
Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat. Am J Physiol Gastrointest Liver Physiol (2009) 1.02
Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS One (2011) 1.02
From urgency to frequency: facts and controversies of TRPs in the lower urinary tract. Nat Rev Urol (2011) 1.01
Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Mol Pain (2012) 1.00
Emerging concepts for the role of TRP channels in the cardiovascular system. J Physiol (2010) 1.00
Thermal and nociceptive sensations from menthol and their suppression by dynamic contact. Behav Brain Res (2006) 1.00
Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract (2010) 0.99
The role of GDNF family ligand signalling in the differentiation of sympathetic and dorsal root ganglion neurons. Cell Tissue Res (2008) 0.99
α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. J Neurosci (2013) 0.98
The coding of cutaneous temperature in the spinal cord. Nat Neurosci (2016) 0.96
Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Invest Ophthalmol Vis Sci (2012) 0.95
Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats. Neurosci Lett (2010) 0.95
Analysis of transient receptor potential ankyrin 1 (TRPA1) in frogs and lizards illuminates both nociceptive heat and chemical sensitivities and coexpression with TRP vanilloid 1 (TRPV1) in ancestral vertebrates. J Biol Chem (2012) 0.95
Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat. Eur J Neurosci (2008) 0.95
Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A (2014) 0.94
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol (2011) 0.93
TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun (2014) 0.93
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels. Br J Pharmacol (2010) 0.92
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS One (2012) 0.92
A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate. J Neurosci (2011) 0.92
Self- and cross-desensitization of oral irritation by menthol and cinnamaldehyde (CA) via peripheral interactions at trigeminal sensory neurons. Chem Senses (2010) 0.92
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material. Mol Pharmacol (2011) 0.92
Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. Br J Pharmacol (2014) 0.91
Eccentric muscle contraction and stretching evoke mechanical hyperalgesia and modulate CGRP and P2X(3) expression in a functionally relevant manner. Pain (2010) 0.91
Cross-desensitization of responses of rat trigeminal subnucleus caudalis neurons to cinnamaldehyde and menthol. Neurosci Lett (2007) 0.91
TRPV1: A Potential Drug Target for Treating Various Diseases. Cells (2014) 0.91
Plasticity in intact A delta- and C-fibers contributes to cold hypersensitivity in neuropathic rats. Neuroscience (2007) 0.90
TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis. J Neurophysiol (2011) 0.89
TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. J Endod (2007) 0.89
Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin. Mol Pain (2011) 0.88
The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Mol Pain (2011) 0.88
Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol. J Neurosci (2013) 0.88
New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view. Pharmaceuticals (Basel) (2011) 0.87
Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Neurosci Bull (2012) 0.87
Effects of hot and cold stimulus combinations on the thermal preference of rats. Behav Brain Res (2009) 0.87
High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors. Mol Pain (2009) 0.87
Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons. J Neurophysiol (2014) 0.86
Transient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease? Curr Opin Cardiol (2008) 0.86
Chronic alteration in phosphatidylinositol 4,5-biphosphate levels regulates capsaicin and mustard oil responses. J Neurosci Res (2011) 0.86
Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons. Exp Neurol (2013) 0.86
Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain (2011) 0.85
Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
Perception of specific trigeminal chemosensory agonists. Neuroscience (2011) 0.85
Mustard oil enhances spinal neuronal responses to noxious heat but not cooling. Neurosci Lett (2009) 0.85
Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors. Mol Pain (2010) 0.84
Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats. Exp Biol Med (Maywood) (2012) 0.84
TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity. Mol Pain (2013) 0.84
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci (2011) 2.90
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
Estimation of fish biomass using environmental DNA. PLoS One (2012) 2.56
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc (2009) 2.20
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci (2004) 2.04
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci (2004) 1.99
Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci (2002) 1.96
Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis (2011) 1.82
MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci (2004) 1.81
The TREAT-NMD Duchenne muscular dystrophy registries: conception, design, and utilization by industry and academia. Hum Mutat (2013) 1.78
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain (2008) 1.78
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci (2003) 1.69
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J Neurosci (2008) 1.55
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol (2006) 1.48
Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation. Pain (2011) 1.48
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci (2003) 1.40
The development of 7E chromosome-specific molecular markers for Thinopyrum elongatum based on SLAF-seq technology. PLoS One (2013) 1.40
Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons. J Comp Neurol (2008) 1.38
Parapapillary atrophy: histological gamma zone and delta zone. PLoS One (2012) 1.38
BDNF in sensory neurons and chronic pain. Neurosci Res (2006) 1.38
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron (2013) 1.34
Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci (2008) 1.34
VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation. Pain (2002) 1.29
The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations. Hum Mutat (2015) 1.26
Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. J Comp Neurol (2006) 1.25
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A (2010) 1.25
A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci (2011) 1.22
Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat. J Comp Neurol (2005) 1.21
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. J Neurosci (2006) 1.20
Three generic nevirapine-based antiretroviral treatments in Chinese HIV/AIDS patients: multicentric observation cohort. PLoS One (2008) 1.19
A case report of a renal anastomosing hemangioma and a literature review: an unusual variant histologically mimicking angiosarcoma. Diagn Pathol (2014) 1.17
The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain (2006) 1.15
Retracted Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury. J Neurochem (2008) 1.14