Published in J Biol Chem on July 14, 2003
Kinesin's second step. Proc Natl Acad Sci U S A (2004) 1.75
To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5. Curr Opin Cell Biol (2006) 1.31
Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control. Nat Cell Biol (2013) 1.14
Loop L5 acts as a conformational latch in the mitotic kinesin Eg5. J Biol Chem (2010) 1.02
Kinesin processivity is gated by phosphate release. Proc Natl Acad Sci U S A (2014) 1.01
Processive movement by a kinesin heterodimer with an inactivating mutation in one head. Biochemistry (2008) 0.92
Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking. J Biol Chem (2011) 0.90
Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. PLoS Biol (2011) 0.90
Microtubule-kinesin interface mutants reveal a site critical for communication. Biochemistry (2004) 0.81
Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines. Biophys Rev (2015) 0.75
Fast-forward genetics by radiation hybrids to saturate the locus regulating nuclear-cytoplasmic compatibility in Triticum. Plant Biotechnol J (2016) 0.75
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
The way things move: looking under the hood of molecular motor proteins. Science (2000) 7.28
A structural change in the kinesin motor protein that drives motility. Nature (1999) 6.92
Structural mechanism of muscle contraction. Annu Rev Biochem (1999) 5.56
Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc Natl Acad Sci U S A (1994) 4.69
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature (1996) 4.48
Force production by single kinesin motors. Nat Cell Biol (2000) 3.87
Pathway of processive ATP hydrolysis by kinesin. Nature (1995) 3.46
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell (1997) 3.17
Kinesin ATPase: rate-limiting ADP release. Proc Natl Acad Sci U S A (1988) 3.06
Switch-based mechanism of kinesin motors. Nature (2001) 2.86
Bovine brain kinesin is a microtubule-activated ATPase. Proc Natl Acad Sci U S A (1986) 2.80
The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell (1997) 2.69
Interacting head mechanism of microtubule-kinesin ATPase. J Biol Chem (1997) 2.57
Reversal in the direction of movement of a molecular motor. Nature (1997) 2.43
ADP-induced rocking of the kinesin motor domain revealed by single-molecule fluorescence polarization microscopy. Nat Struct Biol (2001) 2.34
Role of the kinesin neck linker and catalytic core in microtubule-based motility. Curr Biol (2000) 2.34
Swing of the lever arm of a myosin motor at the isomerization and phosphate-release steps. Nature (1998) 2.12
Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat Struct Biol (2002) 2.06
Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli. Biochemistry (1993) 2.06
Switches, latches, and amplifiers: common themes of G proteins and molecular motors. J Cell Biol (1996) 2.02
Pathway of ATP hydrolysis by monomeric and dimeric kinesin. Biochemistry (1998) 2.01
Direction determination in the minus-end-directed kinesin motor ncd. Nature (1998) 1.96
Alternating site mechanism of the kinesin ATPase. Biochemistry (1998) 1.90
Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change. J Cell Biol (2000) 1.83
Active site comparisons highlight structural similarities between myosin and other P-loop proteins. Biophys J (1996) 1.80
X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry (1997) 1.71
A structural pathway for activation of the kinesin motor ATPase. EMBO J (2001) 1.64
Determinants of kinesin motor polarity. Science (1998) 1.58
Lethal kinesin mutations reveal amino acids important for ATPase activation and structural coupling. J Biol Chem (1999) 1.56
Pre-steady-state kinetics of the microtubule-kinesin ATPase. Biochemistry (1994) 1.56
Kinetics: a tool to study molecular motors. Methods (2000) 1.56
Mechanism of microtubule kinesin ATPase. Biochemistry (1995) 1.55
Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites. Eur J Biochem (1999) 1.51
Coupled chemical and mechanical reaction steps in a processive Neurospora kinesin. EMBO J (1999) 1.48
The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J Muscle Res Cell Motil (1998) 1.44
ATP reorients the neck linker of kinesin in two sequential steps. J Biol Chem (2001) 1.42
Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin. J Mol Biol (1999) 1.40
Kinesin: switch I & II and the motor mechanism. J Cell Sci (2002) 1.40
Alanine scanning mutagenesis of the switch I region in the ATPase site of Dictyostelium discoideum myosin II. Biochemistry (1997) 1.39
Pathway of ADP-stimulated ADP release and dissociation of tethered kinesin from microtubules. Implications for the extent of processivity. Biochemistry (2002) 1.35
Nucleotide-induced conformations in the neck region of dimeric kinesin. EMBO J (2003) 1.32
Sedimentation studies on the kinesin motor domain constructs K401, K366, and K341. Biochemistry (1995) 1.31
Measuring kinesin's first step. J Biol Chem (2002) 1.23
The structural and mechanochemical cycle of kinesin. Trends Biochem Sci (1998) 1.20
Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules. EMBO J (2001) 1.18
Equilibrium binding studies of non-claret disjunctional protein (Ncd) reveal cooperative interactions between the motor domains. J Biol Chem (1998) 1.16
Functional transitions in myosin: formation of a critical salt-bridge and transmission of effect to the sensitive tryptophan. Proc Natl Acad Sci U S A (1998) 1.14
Molecular dynamics study of the energetic, mechanistic, and structural implications of a closed phosphate tube in ncd. Biophys J (2001) 1.14
Structure of a genetically engineered molecular motor. EMBO J (2001) 1.13
Mutational analysis of the switch II loop of Dictyostelium myosin II. J Biol Chem (1998) 1.10
The role of ATP hydrolysis for kinesin processivity. J Biol Chem (2002) 1.10
Motor domain mutation traps kinesin as a microtubule rigor complex. Biochemistry (2003) 1.06
Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing. Biophys J (1998) 1.05
Early stages of energy transduction by myosin: roles of Arg in switch I, of Glu in switch II, and of the salt-bridge between them. Proc Natl Acad Sci U S A (2002) 1.04
EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain. Biophys J (2003) 1.02
A mechanistic model for Ncd directionality. J Biol Chem (2001) 1.01
The structure of the nucleotide-binding site of kinesin. Biol Chem (1999) 0.91
A kinesin mutation that uncouples motor domains and desensitizes the gamma-phosphate sensor. J Biol Chem (2000) 0.90
Opening of the myosin nucleotide triphosphate binding domain during the ATPase cycle. Biochemistry (1997) 0.90
Moving a microtubule may require two heads: a kinetic investigation of monomeric Ncd. Biochemistry (2000) 0.89
Monastrol inhibition of the mitotic kinesin Eg5. J Biol Chem (2005) 3.49
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro. Nat Cell Biol (2006) 2.73
Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell (2005) 2.44
Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site. Cell (2007) 2.26
Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends. Curr Biol (2005) 1.83
Kinesin's second step. Proc Natl Acad Sci U S A (2004) 1.75
The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature (2010) 1.74
Mechanistic analysis of the mitotic kinesin Eg5. J Biol Chem (2004) 1.38
Modulation of kinesin binding by the C-termini of tubulin. EMBO J (2004) 1.35
ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol. Biochemistry (2005) 1.32
To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5. Curr Opin Cell Biol (2006) 1.31
A structural model for monastrol inhibition of dimeric kinesin Eg5. EMBO J (2006) 1.27
Patient and physician-assessed shoulder function after arthroplasty. J Bone Joint Surg Am (2006) 1.26
Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK. Mol Biol Cell (2005) 1.18
Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro. Mol Biol Cell (2005) 1.16
The role of ATP hydrolysis for kinesin processivity. J Biol Chem (2002) 1.10
Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem (2007) 1.08
Motor domain mutation traps kinesin as a microtubule rigor complex. Biochemistry (2003) 1.06
Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis. J Biol Chem (2006) 1.05
Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J (2010) 1.03
Pathway of ATP hydrolysis by monomeric kinesin Eg5. Biochemistry (2006) 1.01
Mitotic kinesin CENP-E promotes microtubule plus-end elongation. Curr Biol (2010) 1.01
The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility. J Biol Chem (2002) 0.98
Synthesis of 9-acridinyl sulfur derivatives: sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells. Eur J Med Chem (2004) 0.96
Lattice structure of cytoplasmic microtubules in a cultured Mammalian cell. J Mol Biol (2009) 0.95
Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern. J Cell Biol (2012) 0.91
Machine-learning techniques for macromolecular crystallization data. Acta Crystallogr D Biol Crystallogr (2004) 0.90
Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking. J Biol Chem (2011) 0.90
Adaptive integration method for Monte Carlo simulations. Phys Rev E Stat Nonlin Soft Matter Phys (2004) 0.89
The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke. J Biol Chem (2012) 0.88
Structural and thermodynamic basis for enhanced DNA binding by a promiscuous mutant EcoRI endonuclease. Structure (2007) 0.86
Microtubule-kinesin interface mutants reveal a site critical for communication. Biochemistry (2004) 0.81
Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3. J Biol Chem (2004) 0.81
Microtubule capture by mitotic kinesin centromere protein E (CENP-E). J Biol Chem (2012) 0.81
Common mechanistic themes for the powerstroke of kinesin-14 motors. J Struct Biol (2013) 0.80
Automatic implementation of precise grid screens: the four-corners method. Acta Crystallogr D Biol Crystallogr (2009) 0.80
Kar3Vik1 uses a minus-end directed powerstroke for movement along microtubules. PLoS One (2013) 0.79
New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I). Nanomedicine (2006) 0.77