Published in Nature on February 23, 1995
Direct observation of single kinesin molecules moving along microtubules. Nature (1996) 5.77
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature (1996) 4.48
Monastrol inhibition of the mitotic kinesin Eg5. J Biol Chem (2005) 3.49
Probing the kinesin reaction cycle with a 2D optical force clamp. Proc Natl Acad Sci U S A (2003) 3.25
Stepping and stretching. How kinesin uses internal strain to walk processively. J Biol Chem (2003) 2.60
DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids. EMBO J (2001) 2.43
Heterotrimeric kinesin II is the microtubule motor protein responsible for pigment dispersion in Xenopus melanophores. J Cell Biol (1998) 2.33
Kinesin's processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domains. Proc Natl Acad Sci U S A (1999) 2.27
Molecular requirements for bi-directional movement of phagosomes along microtubules. J Cell Biol (1997) 2.13
Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin. Biophys J (1995) 2.11
Switches, latches, and amplifiers: common themes of G proteins and molecular motors. J Cell Biol (1996) 2.02
An atomic-level mechanism for activation of the kinesin molecular motors. Proc Natl Acad Sci U S A (2010) 1.93
Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain. Proc Natl Acad Sci U S A (2006) 1.85
Detection of sub-8-nm movements of kinesin by high-resolution optical-trap microscopy. Proc Natl Acad Sci U S A (1996) 1.78
Kinesin's second step. Proc Natl Acad Sci U S A (2004) 1.75
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci U S A (2010) 1.72
Kinetic and equilibrium analysis of the myosin ATPase. Methods Enzymol (2009) 1.66
Lethal kinesin mutations reveal amino acids important for ATPase activation and structural coupling. J Biol Chem (1999) 1.56
Late events of translation initiation in bacteria: a kinetic analysis. EMBO J (2000) 1.54
Kinetics of force generation by single kinesin molecules activated by laser photolysis of caged ATP. Proc Natl Acad Sci U S A (1997) 1.53
Biochemical kinetic characterization of the Acanthamoeba myosin-I ATPase. J Cell Biol (1996) 1.47
What kinesin does at roadblocks: the coordination mechanism for molecular walking. EMBO J (2003) 1.41
Mechanistic analysis of the mitotic kinesin Eg5. J Biol Chem (2004) 1.38
Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with x-ray structure and implications for motility. J Cell Biol (1998) 1.35
ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol. Biochemistry (2005) 1.32
KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry. EMBO J (2001) 1.30
Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes. Mol Biol Cell (1999) 1.24
Polarity of microtubule assemblies during neuronal cell migration. Proc Natl Acad Sci U S A (1996) 1.23
The kinesin walk: a dynamic model with elastically coupled heads. Proc Natl Acad Sci U S A (1996) 1.15
Kinetics processivity and the direction of motion of Ncd. Biophys J (1999) 1.14
Motor protein mechanics: a stochastic model with minimal mechanochemical coupling. Biophys J (1996) 1.11
Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem (2007) 1.08
The shapes of the motor domains of two oppositely directed microtubule motors, ncd and kinesin: a neutron scattering study. Biophys J (1995) 1.06
Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis. J Biol Chem (2006) 1.05
Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing. Biophys J (1998) 1.05
The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization. EMBO J (2011) 1.04
Examining kinesin processivity within a general gating framework. Elife (2015) 1.03
Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity. Mol Biol Cell (2001) 1.01
Pathway of ATP hydrolysis by monomeric kinesin Eg5. Biochemistry (2006) 1.01
Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa. EMBO J (2001) 1.00
A kinesin switch I arginine to lysine mutation rescues microtubule function. J Biol Chem (2003) 0.99
Direct tests of muscle cross-bridge theories: predictions of a Brownian dumbbell model for position-dependent cross-bridge lifetimes and step sizes with an optically trapped actin filament. Biophys J (1998) 0.99
Rotary DNA motors. Biophys J (1995) 0.97
Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase. Nucleic Acids Res (2009) 0.96
The ATPase cycle of the mitotic motor CENP-E. J Biol Chem (2009) 0.95
Effects of α-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system. Biophys J (2014) 0.92
Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking. J Biol Chem (2011) 0.90
A kinesin mutation that uncouples motor domains and desensitizes the gamma-phosphate sensor. J Biol Chem (2000) 0.90
Single fungal kinesin motor molecules move processively along microtubules. Biophys J (2003) 0.89
Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons. Toxicol Sci (2010) 0.89
The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke. J Biol Chem (2012) 0.88
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering. Biophys J (1996) 0.88
Design strategies of fluorescent biosensors based on biological macromolecular receptors. Sensors (Basel) (2010) 0.88
A chemically reversible Brownian motor: application to kinesin and Ncd. Biophys J (1999) 0.88
The role of thermal activation in motion and force generation by molecular motors. Philos Trans R Soc Lond B Biol Sci (2000) 0.87
A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity. EMBO J (1996) 0.86
Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J Biol Chem (2012) 0.85
Kinesin-2 KIF3AB exhibits novel ATPase characteristics. J Biol Chem (2014) 0.84
Fluctuation in the microtubule sliding movement driven by kinesin in vitro. Biophys J (1996) 0.83
Pathway of the microtubule-kinesin ATPase. Biophys J (1995) 0.83
Pressure-induced changes in the structure and function of the kinesin-microtubule complex. Biophys J (2009) 0.82
Kinesins with extended neck linkers: a chemomechanical model for variable-length stepping. Bull Math Biol (2011) 0.82
Microtubule-kinesin interface mutants reveal a site critical for communication. Biochemistry (2004) 0.81
Microtubule capture by mitotic kinesin centromere protein E (CENP-E). J Biol Chem (2012) 0.81
Mechanism of cohesin loading onto chromosomes: a conformational dynamics study. Biophys J (2010) 0.80
Kinesin force generation measured using a centrifuge microscope sperm-gliding motility assay. Biophys J (1996) 0.79
Highly loaded behavior of kinesins increases the robustness of transport under high resisting loads. PLoS Comput Biol (2015) 0.79
Neck-linker docking coordinates the kinetics of kinesin's heads. Biophys J (2011) 0.78
ATPase activity of Escherichia coli Rep helicase crosslinked to single-stranded DNA: implications for ATP driven helicase translocation. Proc Natl Acad Sci U S A (1996) 0.77
Molecular motors. Two heads are better than one. Nature (1995) 0.77
Use of stopped-flow fluorescence and labeled nucleotides to analyze the ATP turnover cycle of kinesins. J Vis Exp (2014) 0.77
Family-specific Kinesin Structures Reveal Neck-linker Length Based on Initiation of the Coiled-coil. J Biol Chem (2016) 0.76
Revealingly odd couples. Proc Natl Acad Sci U S A (2002) 0.76
Development of a Reagentless Biosensor for Inorganic Phosphate, Applicable over a Wide Concentration Range. Biochemistry (2015) 0.76
Heterodimerization of Kinesin-2 KIF3AB Modulates Entry into the Processive Run. J Biol Chem (2016) 0.75
Back to the tubule: microtubule dynamics in Parkinson's disease. Cell Mol Life Sci (2016) 0.75
Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines. Biophys Rev (2015) 0.75
Processivity of kinesin motility is enhanced on increasing temperature. Biophysics (Nagoya-shi) (2006) 0.75
Metal switch-controlled myosin II from Dictyostelium discoideum supports closure of nucleotide pocket during ATP binding coupled to detachment from actin filaments. J Biol Chem (2013) 0.75
Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia. PLoS One (2017) 0.75
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife (2017) 0.75
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell (1985) 13.73
An improved assay for nanomole amounts of inorganic phosphate. Anal Biochem (1979) 13.55
Bead movement by single kinesin molecules studied with optical tweezers. Nature (1990) 8.23
Movement of microtubules by single kinesin molecules. Nature (1989) 7.31
A novel brain ATPase with properties expected for the fast axonal transport motor. Nature (1985) 5.30
Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase. Biochemistry (1994) 4.97
Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc Natl Acad Sci U S A (1994) 4.69
Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system. Anal Biochem (1983) 4.09
Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle. Nature (1986) 3.44
Chemomechanical cycle of kinesin differs from that of myosin. Nature (1993) 3.22
Kinesin ATPase: rate-limiting ADP release. Proc Natl Acad Sci U S A (1988) 3.06
Dissociation of the actin.subfragment 1 complex by adenyl-5'-yl imidodiphosphate, ADP, and PPi. J Biol Chem (1980) 2.98
Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein. Proc Natl Acad Sci U S A (1993) 2.70
New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as substrates for various enzymes. Biochim Biophys Acta (1983) 2.45
Quantized velocities at low myosin densities in an in vitro motility assay. Nature (1991) 2.28
Pathway of the microtubule-dynein ATPase and the structure of dynein: a comparison with actomyosin. Annu Rev Biophys Biophys Chem (1985) 2.17
Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli. Biochemistry (1993) 2.06
Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP. Nature (1985) 1.96
Decoration of the microtubule surface by one kinesin head per tubulin heterodimer. Nature (1993) 1.69
Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: characterization of two acto-S1-ADP complexes. Biochemistry (1991) 1.68
Pre-steady-state kinetics of the microtubule-kinesin ATPase. Biochemistry (1994) 1.56
A kinetic study of the kinesin ATPase. J Biol Chem (1992) 1.37
Microtubules accelerate ADP release by dynein. Biochemistry (1989) 1.27
A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci U S A (1993) 6.50
Negative feedback defining a circadian clock: autoregulation of the clock gene frequency. Science (1994) 5.76
Birth outcomes in pregnant women taking fluoxetine. N Engl J Med (1996) 5.38
Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro. Ann N Y Acad Sci (1975) 5.26
Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol (2003) 5.17
Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase. Biochemistry (1994) 4.97
Mechanism and fidelity of HIV reverse transcriptase. J Biol Chem (1992) 4.57
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. Biochemistry (1991) 4.55
Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry (1987) 4.29
Kinetic mechanism of DNA polymerase I (Klenow). Biochemistry (1987) 3.93
An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics. Biochemistry (1991) 3.86
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science (1995) 3.60
Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry (1996) 3.36
The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A (1993) 3.25
Circadian clock locus frequency: protein encoded by a single open reading frame defines period length and temperature compensation. Proc Natl Acad Sci U S A (1994) 3.23
Kinetic analysis of microtubule self-assembly in vitro. J Mol Biol (1977) 3.15
Imaging amyloid deposition in Lewy body diseases. Neurology (2008) 3.09
Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest (1982) 2.92
Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed. Biochemistry (2000) 2.82
Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med (1989) 2.56
The scintigraphic appearance of Alzheimer's disease: a prospective study using technetium-99m-HMPAO SPECT. J Nucl Med (1992) 2.39
Role of tubulin-associated proteins in microtubule nucleation and elongation. J Mol Biol (1977) 2.38
Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism. Biochemistry (1978) 2.35
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. J Biol Chem (2001) 2.31
Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism. EMBO J (2000) 2.27
Kinetics of nucleoside triphosphate cleavage and phosphate release steps by associated rabbit skeletal actomyosin, measured using a novel fluorescent probe for phosphate. Biochemistry (1997) 2.23
Mechanism of inorganic phosphate interaction with phosphate binding protein from Escherichia coli. Biochemistry (1998) 2.23
Microtuble assembly: some possible regulatory mechanisms. J Supramol Struct (1974) 2.21
Pathway of the microtubule-dynein ATPase and the structure of dynein: a comparison with actomyosin. Annu Rev Biophys Biophys Chem (1985) 2.17
Incidence of Colles' fracture in a North American community. Am J Public Health (1982) 2.17
Association between wild type and mutant APC gene products. Cancer Res (1993) 2.08
Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli. Biochemistry (1993) 2.06
rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1988) 2.06
Structure and molecular weight of the dynein ATPase. J Cell Biol (1983) 2.01
Pathway of ATP hydrolysis by monomeric and dimeric kinesin. Biochemistry (1998) 2.01
Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant (2009) 2.00
Impingement of the lesser trochanter on the ischial ramus after total hip arthroplasty. Report of three cases. J Bone Joint Surg Am (1977) 1.97
Alternating site mechanism of the kinesin ATPase. Biochemistry (1998) 1.90
Oxygen exchange between Pi in the medium and water during ATP hydrolysis mediated by skinned fibers from rabbit skeletal muscle. Evidence for Pi binding to a force-generating state. J Biol Chem (1986) 1.89
ATPase kinetics on activation of rabbit and frog permeabilized isometric muscle fibres: a real time phosphate assay. J Physiol (1997) 1.88
Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging. Neuropathol Appl Neurobiol (2015) 1.86
Expression of the APC tumor suppressor protein in oligodendroglia. Glia (1996) 1.77
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. Proc Natl Acad Sci U S A (1990) 1.74
Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant (2001) 1.74
Elementary steps in the DNA polymerase I reaction pathway. Biochemistry (1983) 1.73
Rapid kinetic analysis of mechanochemical adenosinetriphosphatases. Methods Enzymol (1986) 1.72
The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense. Proc Natl Acad Sci U S A (2003) 1.72
H. M.'s medial temporal lobe lesion: findings from magnetic resonance imaging. J Neurosci (1997) 1.71
Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. Am J Clin Nutr (1989) 1.71
Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol (1986) 1.70
Decoration of the microtubule surface by one kinesin head per tubulin heterodimer. Nature (1993) 1.69
Dynamics of ribozyme binding of substrate revealed by fluorescence-detected stopped-flow methods. Science (1992) 1.69
Sulfur transfer from IscS to IscU: the first step in iron-sulfur cluster biosynthesis. J Am Chem Soc (2001) 1.68
Characterization of the ATP-sensitive binding of Tetrahymena 30 S dynein to bovine brain microtubules. J Biol Chem (1983) 1.67
Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization. Biochemistry (2000) 1.62
Exonuclease proofreading by human mitochondrial DNA polymerase. J Biol Chem (2001) 1.60
Rescue of a paralyzed-flagella mutant of Chlamydomonas by transformation. Proc Natl Acad Sci U S A (1990) 1.60
Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction. Biochemistry (1991) 1.60
Evaluation of a surveillance strategy for early detection of adenovirus by PCR of peripheral blood in hematopoietic SCT recipients: incidence and outcome. Bone Marrow Transplant (2010) 1.59
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue. Nat Struct Biol (1997) 1.58
Pre-steady-state kinetics of the microtubule-kinesin ATPase. Biochemistry (1994) 1.56
Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane. Biochem J (1994) 1.55
Cloning and sequencing of the adenylate kinase gene (adk) of Escherichia coli. Nucleic Acids Res (1985) 1.53
Large scale purification and biochemical characterization of T7 primase/helicase proteins. Evidence for homodimer and heterodimer formation. J Biol Chem (1992) 1.52
Musculoskeletal and soft tissue Aeromonas infection: an environmental disease. Mayo Clin Proc (1992) 1.52
Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit. Proc Natl Acad Sci U S A (1994) 1.51
Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. Cancer Res (1996) 1.49
The efficiency of contraction in rabbit skeletal muscle fibres, determined from the rate of release of inorganic phosphate. J Physiol (1999) 1.48
Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase. J Biol Chem (2001) 1.47
Rate-limiting steps in the DNA polymerase I reaction pathway. Biochemistry (1985) 1.46
The patellar tendon-bearing brace as treatment for neurotrophic arthropathy: a dynamic force monitoring study. Foot Ankle (1992) 1.44
Isolated talocalcaneal arthrodesis. A technique using moldable bone graft. J Bone Joint Surg Am (1988) 1.44
Circadian rhythms. Brain Res Brain Res Rev (1993) 1.43
Colles' fracture and subsequent hip fracture risk. Clin Orthop Relat Res (1983) 1.43
A hexameric helicase encircles one DNA strand and excludes the other during DNA unwinding. Biochemistry (1997) 1.40
Outcome of femoral head ostectomy in dogs and cats. Munich publication reprinted. Vet Comp Orthop Traumatol (2010) 1.39
Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase. Biochemistry (1998) 1.39
"What's a foot surgeon to believe?". Foot Ankle (1993) 1.39
A relational database for diagnosis of hematopoietic neoplasms using immunophenotyping by flow cytometry. Am J Clin Pathol (2000) 1.38
Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase. Proc Natl Acad Sci U S A (2001) 1.35
Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr (1991) 1.33
Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. Arterioscler Thromb Vasc Biol (2006) 1.32
Activation of the dynein adenosinetriphosphatase by microtubules. Biochemistry (1986) 1.32
Presteady state kinetic analysis of vanadate-induced inhibition of the dynein ATPase. J Biol Chem (1983) 1.31
Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone (1994) 1.31
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs. J Biol Chem (2001) 1.31
The results of anterior interbody fusion of the cervical spine. Review of ninety-three consecutive cases. J Neurosurg (1969) 1.31
Sedimentation studies on the kinesin motor domain constructs K401, K366, and K341. Biochemistry (1995) 1.31
Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene. Cancer Res (1992) 1.30
Identification of a molecular chaperone in the eukaryotic flagellum and its localization to the site of microtubule assembly. J Cell Sci (1995) 1.30
The mechanism of guanosine nucleotide hydrolysis by p21 c-Ha-ras. The stereochemical course of the GTPase reaction. J Biol Chem (1989) 1.30
Allogeneic hematopoietic SCT for patients with autoimmune diseases. Bone Marrow Transplant (2009) 1.28
Radiographic measurements of the normal adult foot. Foot Ankle (1980) 1.27
Microtubules accelerate ADP release by dynein. Biochemistry (1989) 1.27
Effects of biological source on cooking and palatability attributes of beef produced for the Japanese market. Meat Sci (1993) 1.27
Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli. Biochemistry (1988) 1.26
Competitive inhibition of iron absorption by manganese and zinc in humans. Am J Clin Nutr (1991) 1.26