Published in Science on July 18, 2003
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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri. Science (2010) 3.70
Noncoding RNA in development. Mamm Genome (2008) 3.42
An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81
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The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proc Natl Acad Sci U S A (2008) 2.00
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Evidence for sex and recombination in the choanoflagellate Salpingoeca rosetta. Curr Biol (2013) 1.55
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The evolution of metazoan extracellular matrix. J Cell Biol (2012) 1.39
Evolution of sodium channels predates the origin of nervous systems in animals. Proc Natl Acad Sci U S A (2011) 1.34
Nf2/Merlin: a coordinator of receptor signalling and intercellular contact. Br J Cancer (2007) 1.30
Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals. Proc Natl Acad Sci U S A (2006) 1.29
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Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex. Proc Natl Acad Sci U S A (2012) 1.22
The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example. Dev Biol (2009) 1.21
Sterols in a unicellular relative of the metazoans. Proc Natl Acad Sci U S A (2008) 1.18
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol (2007) 1.17
The evolution of phototransduction from an ancestral cyclic nucleotide gated pathway. Proc Biol Sci (2010) 1.14
Molecular evolution of the MAGUK family in metazoan genomes. BMC Evol Biol (2007) 1.14
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Premetazoan origin of the hippo signaling pathway. Cell Rep (2011) 1.12
Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol (2011) 1.12
Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation. J Biol Chem (2008) 1.12
FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian. Dev Genes Evol (2007) 1.08
The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Res (2011) 1.07
Regeneration and the need for simpler model organisms. Philos Trans R Soc Lond B Biol Sci (2004) 1.07
Cadherins in maternal-foetal interactions: red queen with a green beard? Proc Biol Sci (2005) 1.06
Complete genome sequence of Algoriphagus sp. PR1, bacterial prey of a colony-forming choanoflagellate. J Bacteriol (2010) 1.06
Diverse evolutionary paths to cell adhesion. Trends Cell Biol (2010) 1.05
Origins and evolution of the formin multigene family that is involved in the formation of actin filaments. Mol Biol Evol (2008) 1.03
Harnessing nature's toolbox: regulatory elements for synthetic biology. J R Soc Interface (2009) 1.00
The VARL gene family and the evolutionary origins of the master cell-type regulatory gene, regA, in Volvox carteri. J Mol Evol (2007) 1.00
The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans. BMC Evol Biol (2008) 0.97
Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci (2008) 0.96
Lung evolution as a cipher for physiology. Physiol Genomics (2009) 0.94
Ancient origin of the new developmental superfamily DANGER. PLoS One (2007) 0.94
Early origin of the bilaterian developmental toolkit. Philos Trans R Soc Lond B Biol Sci (2009) 0.92
A central theory of biology. Med Hypotheses (2015) 0.89
Genome analysis of the unicellular green alga Chlamydomonas reinhardtii Indicates an ancient evolutionary origin for key pattern recognition and cell-signaling protein families. Genetics (2008) 0.88
Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association. Biochem J (2004) 0.86
Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal (2012) 0.86
Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development. J Biol Chem (2010) 0.85
Scalable production of highly sensitive nanosensors based on graphene functionalized with a designed G protein-coupled receptor. Nano Lett (2014) 0.85
An olfactory receptor pseudogene whose function emerged in humans: a case study in the evolution of structure-function in GPCRs. J Struct Funct Genomics (2008) 0.85
Tuning up the right signal: chemical and genetic approaches to study GPCR functions. Curr Opin Cell Biol (2013) 0.84
Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family. Exp Cell Res (2005) 0.84
Exploiting cellular-developmental evolution as the scientific basis for preventive medicine. Med Hypotheses (2009) 0.84
Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling. Proc Natl Acad Sci U S A (2012) 0.84
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SH3 domain tyrosine phosphorylation--sites, role and evolution. PLoS One (2012) 0.83
Tyrosine kinase signaling and the emergence of multicellularity. Biochim Biophys Acta (2012) 0.83
Cell signaling and transcription factor genes expressed during whole body regeneration in a colonial chordate. BMC Dev Biol (2008) 0.83
Earliest Holozoan expansion of phosphotyrosine signaling. Mol Biol Evol (2013) 0.83
Punctuated emergences of genetic and phenotypic innovations in eumetazoan, bilaterian, euteleostome, and hominidae ancestors. Genome Biol Evol (2013) 0.82
p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling. Biochemistry (2010) 0.81
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Bacterial influences on animal origins. Cold Spring Harb Perspect Biol (2014) 0.81
Deciphering unusual uncultured magnetotactic multicellular prokaryotes through genomics. ISME J (2013) 0.81
Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program. Mol Biol Evol (2014) 0.80
Cell-cell signaling drives the evolution of complex traits: introduction-lung evo-devo. Integr Comp Biol (2009) 0.80
The role of peptide motifs in the evolution of a protein network. Nucleic Acids Res (2007) 0.80
Evolution of an ancient protein function involved in organized multicellularity in animals. Elife (2016) 0.79
Exploring metazoan evolution through dynamic and holistic changes in protein families and domains. BMC Evol Biol (2012) 0.78
Draft genome of Brugia pahangi: high similarity between B. pahangi and B. malayi. Parasit Vectors (2015) 0.78
The biological significance of evolution in autoimmune phenomena. Autoimmune Dis (2012) 0.77
The early evolution of the phosphagen kinases--insights from choanoflagellate and poriferan arginine kinases. J Mol Evol (2007) 0.77
Role of class III phosphatidylinositol 3-kinase during programmed nuclear death of Tetrahymena thermophila. Autophagy (2013) 0.77
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Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network. Sci Rep (2015) 0.75
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Possible influence of resistance to malaria in clinical presentation of rheumatoid arthritis: biological significance of natural selection. Arthritis (2012) 0.75
Identification of Three Novel Splicing Variants and Expression Analysis of Chicken GPR1 Gene. Biomed Res Int (2017) 0.75
Convergence of domain architecture, structure and ligand affinity in animal and plant RNA-binding proteins. Mol Biol Evol (2017) 0.75
E-cadherin roles in animal biology: A perspective on thyroid hormone-influence. Cell Commun Signal (2016) 0.75
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The role of cell replacement in benthic-pelagic coupling by suspension feeders. R Soc Open Sci (2016) 0.75
Bioinformatic prediction of G protein-coupled receptor encoding sequences from the transcriptome of the foreleg, including the Haller's organ, of the cattle tick, Rhipicephalus australis. PLoS One (2017) 0.75
Spheres of hope, packets of doom: The good and bad of outer membrane vesicles in interspecies and ecological dynamics. J Bacteriol (2017) 0.75
Novel GPS-containing G protein-coupled receptor from Monosiga brevicollis. Dokl Biochem Biophys (2009) 0.75
Genome-scale approaches to resolving incongruence in molecular phylogenies. Nature (2003) 10.73
Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Nature (2005) 5.52
Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene. Nature (2006) 4.21
Animal evolution and the molecular signature of radiations compressed in time. Science (2005) 3.98
Emerging principles of regulatory evolution. Proc Natl Acad Sci U S A (2007) 3.42
Gene duplication and the adaptive evolution of a classic genetic switch. Nature (2007) 3.41
The evolution of gene regulation underlies a morphological difference between two Drosophila sister species. Cell (2008) 3.10
Evolution of a transcriptional repression domain in an insect Hox protein. Nature (2002) 2.82
Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population. Science (2009) 2.77
Gene co-option in physiological and morphological evolution. Annu Rev Cell Dev Biol (2002) 2.71
Evolution in black and white: genetic control of pigment patterns in Drosophila. Trends Genet (2003) 2.47
Reciprocal functions of the Drosophila yellow and ebony proteins in the development and evolution of pigment patterns. Development (2002) 2.42
Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts. Proc Natl Acad Sci U S A (2004) 2.33
The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila. Cell (2008) 2.27
Evolution of yellow gene regulation and pigmentation in Drosophila. Curr Biol (2002) 2.21
Genetic and molecular insights into the development and evolution of sexual dimorphism. Nat Rev Genet (2009) 2.18
More genes or more taxa? The relative contribution of gene number and taxon number to phylogenetic accuracy. Mol Biol Evol (2005) 2.16
Bushes in the tree of life. PLoS Biol (2006) 2.16
Rapid evolution of sex pheromone-producing enzyme expression in Drosophila. PLoS Biol (2009) 2.09
Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid flies. Nature (2003) 2.08
Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution. Cell (2006) 1.92
Drosophila pigmentation evolution: divergent genotypes underlying convergent phenotypes. Proc Natl Acad Sci U S A (2003) 1.74
Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster. Genetics (2003) 1.70
Molecular mechanisms of selector gene function and evolution. Curr Opin Genet Dev (2002) 1.70
The regulatory content of intergenic DNA shapes genome architecture. Genome Biol (2004) 1.70
Generation of a novel wing colour pattern by the Wingless morphogen. Nature (2010) 1.69
Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites. Development (2002) 1.64
Frequent and widespread parallel evolution of protein sequences. Mol Biol Evol (2008) 1.47
Conflicting phylogenetic signals at the base of the metazoan tree. Evol Dev (2003) 1.24
Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in Drosophila. Development (2005) 1.24
Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences. Proc Natl Acad Sci U S A (2011) 1.24
The UBX-regulated network in the haltere imaginal disc of D. melanogaster. Dev Biol (2006) 1.21
Collaboration between Smads and a Hox protein in target gene repression. Development (2007) 1.19
Downstream DNA selectively affects a paused conformation of human RNA polymerase II. J Mol Biol (2004) 1.08
Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila. Proc Natl Acad Sci U S A (2011) 1.04
A single gene affects both ecological divergence and mate choice in Drosophila. Science (2014) 0.95
Evolution of the tan locus contributed to pigment loss in Drosophila santomea: a response to Matute et al. Cell (2009) 0.94
The evolution of abdominal reduction and the recent origin of distinct Abdominal-B transcript classes in Diptera. Evol Dev (2006) 0.93
Pleiotropic functions of a conserved insect-specific Hox peptide motif. Development (2005) 0.89
Pharmacologic approaches to butterfly wing patterning: sulfated polysaccharides mimic or antagonize cold shock and alter the interpretation of gradients of positional information. Dev Biol (2005) 0.87
Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector protein. Evol Dev (2008) 0.79
Monkey see, monkey do. Nat Genet (2006) 0.76
QnAs with Sean B. Carroll. Proc Natl Acad Sci U S A (2010) 0.75
History: Great myths die hard. Nature (2013) 0.75