Published in Cell on September 03, 2010
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries. Cell Host Microbe (2011) 2.25
Brassinosteroid signal transduction: from receptor kinase activation to transcriptional networks regulating plant development. Plant Cell (2011) 2.03
Operating on chromatin, a colorful language where context matters. J Mol Biol (2011) 2.00
Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor. Genes Dev (2011) 1.81
Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. Mol Syst Biol (2013) 1.78
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol (2012) 1.77
Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol (2013) 1.62
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins. Mol Cell (2016) 1.44
Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. PLoS Genet (2016) 1.43
Unmasking Determinants of Specificity in the Human Kinome. Cell (2015) 1.32
Evolution and functional cross-talk of protein post-translational modifications. Mol Syst Biol (2013) 1.30
Charting the landscape of tandem BRCT domain-mediated protein interactions. Sci Signal (2012) 1.19
Navigating cancer network attractors for tumor-specific therapy. Nat Biotechnol (2012) 1.18
Brassinosteroids. Arabidopsis Book (2011) 1.08
The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Res (2011) 1.07
The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity. Mol Cell (2014) 1.04
A structural perspective on the regulation of the epidermal growth factor receptor. Annu Rev Biochem (2015) 1.04
Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems. Wiley Interdiscip Rev Syst Biol Med (2013) 1.04
The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes. Sci Signal (2011) 1.03
Modular evolution of phosphorylation-based signalling systems. Philos Trans R Soc Lond B Biol Sci (2012) 1.02
Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity. Nat Commun (2013) 1.01
Density-dependent lectin-glycan interactions as a paradigm for conditional regulation by posttranslational modifications. Mol Cell Proteomics (2013) 0.98
LIF-dependent signaling: new pieces in the Lego. Stem Cell Rev (2012) 0.98
Phospho-tyrosine dependent protein-protein interaction network. Mol Syst Biol (2015) 0.96
Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. PLoS One (2013) 0.96
Multiple regulation pathways and pivotal biological functions of STAT3 in cancer. Sci Rep (2015) 0.96
Binding constraints on the evolution of enzymes and signalling proteins: the important role of negative pleiotropy. Proc Biol Sci (2011) 0.95
The brassinosteroid signaling pathway-new key players and interconnections with other signaling networks crucial for plant development and stress tolerance. Int J Mol Sci (2013) 0.95
A domain-centric solution to functional genomics via dcGO Predictor. BMC Bioinformatics (2013) 0.95
Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding. EMBO J (2011) 0.94
Evolution of SH2 domains and phosphotyrosine signalling networks. Philos Trans R Soc Lond B Biol Sci (2012) 0.93
Phosphorylation site dynamics of early T-cell receptor signaling. PLoS One (2014) 0.93
Hsp90 promotes kinase evolution. Mol Biol Evol (2014) 0.91
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nat Commun (2015) 0.90
Engineering visual arrestin-1 with special functional characteristics. J Biol Chem (2012) 0.90
Evolutionary constraint and disease associations of post-translational modification sites in human genomes. PLoS Genet (2015) 0.89
Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications. J Biol Chem (2016) 0.89
Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling. Genes Cancer (2012) 0.88
Signal processing by protein tyrosine phosphorylation in plants. Plant Signal Behav (2011) 0.87
Evolution of the JAK-STAT pathway. JAKSTAT (2013) 0.86
Systematic analysis of the in situ crosstalk of tyrosine modifications reveals no additional natural selection on multiply modified residues. Sci Rep (2014) 0.86
Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal (2012) 0.86
BRCT domains: A little more than kin, and less than kind. FEBS Lett (2012) 0.86
Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal (2013) 0.86
An evolutionary perspective on the kinome of malaria parasites. Philos Trans R Soc Lond B Biol Sci (2012) 0.85
Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer: EGFR and beyond. Chin J Cancer (2015) 0.85
The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling. Genome Biol Evol (2015) 0.84
Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling. Proc Natl Acad Sci U S A (2012) 0.84
Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration. Bioarchitecture (2013) 0.83
Perspective: Dynamics of receptor tyrosine kinase signaling complexes. FEBS Lett (2012) 0.83
ProKinO: a unified resource for mining the cancer kinome. Hum Mutat (2015) 0.83
Tyrosine kinase signaling and the emergence of multicellularity. Biochim Biophys Acta (2012) 0.83
Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. Elife (2014) 0.83
SH3 domain tyrosine phosphorylation--sites, role and evolution. PLoS One (2012) 0.83
Earliest Holozoan expansion of phosphotyrosine signaling. Mol Biol Evol (2013) 0.83
Design principles underpinning the regulatory diversity of protein kinases. Philos Trans R Soc Lond B Biol Sci (2012) 0.83
The application of modular protein domains in proteomics. FEBS Lett (2012) 0.82
The Specific Roles of JAK/STAT Signaling Pathway in Sepsis. Inflammation (2015) 0.81
Exploiting holistic approaches to model specificity in protein phosphorylation. Front Genet (2014) 0.81
Lack of Csk-mediated negative regulation in a unicellular SRC kinase. Biochemistry (2012) 0.81
Quantitative phosphoproteomics analysis reveals broad regulatory role of heparan sulfate on endothelial signaling. Mol Cell Proteomics (2013) 0.81
Cells, shared memory and breaking the PTM code. Mol Syst Biol (2012) 0.81
Protein tyrosine phosphatases as wardens of STAT signaling. JAKSTAT (2014) 0.80
Detecting functional divergence after gene duplication through evolutionary changes in posttranslational regulatory sequences. PLoS Comput Biol (2014) 0.80
Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2. Nat Commun (2013) 0.80
Functional Diversity of the Schistosoma mansoni Tyrosine Kinases. J Signal Transduct (2011) 0.79
Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase. J Biol Chem (2015) 0.79
Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics. Proc Natl Acad Sci U S A (2016) 0.79
The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System. J Biol Chem (2015) 0.78
Mutational properties of amino acid residues: implications for evolvability of phosphorylatable residues. Philos Trans R Soc Lond B Biol Sci (2012) 0.78
Pre-metazoan origins and evolution of the cadherin adhesome. Biol Open (2014) 0.78
The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer. Oncotarget (2016) 0.77
Activation of T-cell protein-tyrosine phosphatase suppresses keratinocyte survival and proliferation following UVB irradiation. J Biol Chem (2014) 0.77
Metazoan-like signaling in a unicellular receptor tyrosine kinase. BMC Biochem (2013) 0.77
Transcriptome sequencing and developmental regulation of gene expression in Anopheles aquasalis. PLoS Negl Trop Dis (2014) 0.77
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes. PLoS One (2014) 0.77
PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis. PLoS One (2011) 0.77
Evolutionary versatility of eukaryotic protein domains revealed by their bigram networks. BMC Evol Biol (2011) 0.77
Testing whether metazoan tyrosine loss was driven by selection against promiscuous phosphorylation. Mol Biol Evol (2014) 0.77
The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol Biol Cell (2014) 0.76
Constitutive Activity in an Ancestral Form of Abl Tyrosine Kinase. PLoS One (2015) 0.76
SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective. Adv Exp Med Biol (2014) 0.76
Use of mechanistic models to integrate and analyze multiple proteomic datasets. Biophys J (2015) 0.76
Engram formation in psychiatric disorders. Front Neurosci (2014) 0.76
Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibrans. Biochemistry (2014) 0.76
Modular engineering of cellular signaling proteins and networks. Curr Opin Struct Biol (2016) 0.75
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal (2017) 0.75
Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain. J Biol Chem (2016) 0.75
Plants get on PAR with poly(ADP-ribosyl)ation. EMBO Rep (2016) 0.75
Correlated duplications and losses in the evolution of palmitoylation writer and eraser families. BMC Evol Biol (2017) 0.75
Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development. Sci Rep (2017) 0.75
Novel Effects of Lapatinib Revealed in the African Trypanosome using Hypothesis-Generating Proteomics and Chemical Biology Strategies. Antimicrob Agents Chemother (2016) 0.75
Signal, transduction, and the hematopoietic stem cell. Rambam Maimonides Med J (2014) 0.75
Neutral Loss is a Very Common Occurrence in Phosphotyrosine-containing Peptides Labeled with Isobaric Tags. J Proteome Res (2016) 0.75
Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nat Chem Biol (2017) 0.75
Targeted activation of the SHP-1/PP2A signalling axis elicits apoptosis of chronic lymphocytic leukemia cells. Haematologica (2017) 0.75
Identification and characterization of tyrosine kinases in anole lizard indicate the conserved tyrosine kinase repertoire in vertebrates. Mol Genet Genomics (2017) 0.75
Protein modules and signalling networks. Nature (1995) 12.53
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
The Amphimedon queenslandica genome and the evolution of animal complexity. Nature (2010) 5.11
Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell (2004) 5.02
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem (2006) 3.60
Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol (2009) 3.31
Combinatorial control of the specificity of protein tyrosine phosphatases. Curr Opin Cell Biol (2001) 3.30
The unicellular ancestry of animal development. Dev Cell (2004) 3.29
Evolution of key cell signaling and adhesion protein families predates animal origins. Science (2003) 2.85
Designing customized cell signalling circuits. Nat Rev Mol Cell Biol (2010) 2.64
Rapid diversification of cell signaling phenotypes by modular domain recombination. Science (2010) 2.49
Positive selection of tyrosine loss in metazoan evolution. Science (2009) 2.28
Eukaryotic protein domains as functional units of cellular evolution. Sci Signal (2009) 2.06
The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proc Natl Acad Sci U S A (2008) 2.00
The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relations. EMBO Rep (2002) 1.94
The origins of multicellularity and the early history of the genetic toolkit for animal development. Annu Rev Genet (2008) 1.89
Protein-tyrosine kinase activity in Saccharomyces cerevisiae. Science (1986) 1.68
Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages. Proc Natl Acad Sci U S A (2008) 1.68
SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium. Cell (1997) 1.38
Protein phosphatases--a phylogenetic perspective. Chem Rev (2001) 1.21
Structure and in vivo requirement of the yeast Spt6 SH2 domain. J Mol Biol (2009) 1.16
An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. Genes Dev (2001) 1.01
Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways. Philos Trans R Soc Lond B Biol Sci (1993) 0.95
Emerging structural insights into bacterial tyrosine kinases. Trends Biochem Sci (2009) 0.93
A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling. J Cell Sci (2008) 0.92
Evidence for convergent evolution in the signaling properties of a choanoflagellate tyrosine kinase. Biochemistry (2009) 0.87
Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development. J Biol Chem (2010) 0.85
Dictyostelium development: lower STATs. Curr Biol (1997) 0.84
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine. BMC Bioinformatics (2003) 6.31
A global protein kinase and phosphatase interaction network in yeast. Science (2010) 5.95
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A (2004) 5.34
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
Cell signaling in space and time: where proteins come together and when they're apart. Science (2009) 3.88
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene (2004) 3.44
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol (2006) 3.42
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell (2006) 3.38
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol (2003) 3.11
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Mol Cell (2006) 2.51
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (2004) 2.51
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet (2004) 2.44
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol (2003) 2.34
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Positive selection of tyrosine loss in metazoan evolution. Science (2009) 2.28
Post-translational modifications in signal integration. Nat Struct Mol Biol (2010) 2.23
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab (2013) 2.21
Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol (2012) 2.16
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci Signal (2009) 2.16
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
Eukaryotic protein domains as functional units of cellular evolution. Sci Signal (2009) 2.06
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol (2006) 2.01
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol (2005) 1.97
Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol (2009) 1.93
Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol (2009) 1.92
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science (2009) 1.91
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol (2011) 1.90
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J (2008) 1.82
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell (2012) 1.79
Defining the specificity space of the human SRC homology 2 domain. Mol Cell Proteomics (2007) 1.78
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A (2009) 1.73
High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell (2007) 1.72
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol (2011) 1.69
Polarity proteins in axon specification and synaptogenesis. Dev Cell (2005) 1.66
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A (2007) 1.65
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics. J Biol Chem (2008) 1.60
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol (2002) 1.49
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol (2003) 1.45
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci U S A (2003) 1.42
Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays. Mol Cell Biol (2006) 1.41
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods (2013) 1.41
Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A (2010) 1.40
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet (2013) 1.39
Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol (2006) 1.36
OpenFreezer: a reagent information management software system. Nat Methods (2011) 1.35
Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol (2008) 1.34
Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A (2007) 1.33
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. J Biol Chem (2007) 1.32
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J (2006) 1.30
Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3. Proc Natl Acad Sci U S A (2008) 1.28
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. Cell Host Microbe (2007) 1.27
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc Natl Acad Sci U S A (2002) 1.26
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. Proc Natl Acad Sci U S A (2008) 1.26
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol (2004) 1.26
Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition. Mol Cell (2003) 1.24
Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein. J Biol Chem (2006) 1.23
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol (2005) 1.20
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science (2007) 1.20
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proc Natl Acad Sci U S A (2004) 1.15
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A (2012) 1.15
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J (2002) 1.15
The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans. Genes Dev (2005) 1.10
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A (2004) 1.10
FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. Mol Cell Biol (2004) 1.09
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1. Proc Natl Acad Sci U S A (2002) 1.08
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors. J Cell Biol (2011) 1.08
Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity. J Biol Chem (2002) 1.03
Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site. Curr Biol (2003) 1.02
Modular evolution of phosphorylation-based signalling systems. Philos Trans R Soc Lond B Biol Sci (2012) 1.02
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol (2002) 1.00
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci (2009) 1.00
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell (2013) 0.99
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol (2013) 0.99