Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.

PubWeight™: 0.94‹?› | Rank: Top 15%

🔗 View Article (PMC 3285345)

Published in J Biol Chem on December 27, 2011

Authors

Bas Heinhuis1, Marije I Koenders, Wim B van den Berg, Mihai G Netea, Charles A Dinarello, Leo A B Joosten

Author Affiliations

1: Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands.

Articles citing this

IL-32 promotes angiogenesis. J Immunol (2013) 0.98

Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε ) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells. J Biol Chem (2012) 0.91

The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells. Leukemia (2014) 0.90

IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis. Sci Rep (2013) 0.85

Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production. J Biol Chem (2013) 0.81

IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis. Mediators Inflamm (2016) 0.79

Role of interleukin-32 in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol (2013) 0.78

IL-32θ gene expression in acute myeloid leukemia suppresses TNF-α production. Oncotarget (2015) 0.76

Maintenance of Epstein-Barr Virus Latent Status by a Novel Mechanism, Latent Membrane Protein 1-Induced Interleukin-32, via the Protein Kinase Cδ Pathway. J Virol (2015) 0.75

IL-32 induces indoleamine 2,3-dioxygenase(+)CD1c(+) dendritic cells and indoleamine 2,3-dioxygenase(+)CD163(+) macrophages: Relevance to mycosis fungoides progression. Oncoimmunology (2016) 0.75

IL-32α-induced inflammation constitutes a link between obesity and colon cancer. Oncoimmunology (2017) 0.75

Increased plasma interleukin-32 expression in patients with neuromyelitis optica. J Clin Immunol (2012) 0.75

IL-32γ promotes integrin αvβ6 expression through the activation of NF-κB in HSCs. Exp Ther Med (2017) 0.75

Articles cited by this

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis (1997) 57.27

I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc (2010) 22.66

I-TASSER server for protein 3D structure prediction. BMC Bioinformatics (2008) 18.28

Integrin signaling. Science (1999) 16.44

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature (1984) 14.25

The HMMTOP transmembrane topology prediction server. Bioinformatics (2001) 12.57

RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol (1996) 9.77

Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell (1985) 8.55

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science (2002) 7.87

A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci U S A (1985) 4.44

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature (1996) 3.88

Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem (2007) 3.87

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol Cell (1996) 3.60

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene (2000) 3.44

Interleukin-32: a cytokine and inducer of TNFalpha. Immunity (2005) 3.39

Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Cell (1991) 2.81

The ins and outs of leukocyte integrin signaling. Annu Rev Immunol (2009) 2.76

IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A (2006) 2.67

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle (2010) 2.67

Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Trends Biochem Sci (1991) 2.62

RGD peptides induce apoptosis by direct caspase-3 activation. Nature (1999) 2.54

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46

The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem (2000) 2.17

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol (2002) 2.11

Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med (2006) 2.04

Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov (2003) 1.98

Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin Exp Immunol (2007) 1.87

Identification of a novel gene expressed in activated natural killer cells and T cells. J Immunol (1992) 1.82

Vitronectin--a major cell attachment-promoting protein in fetal bovine serum. Exp Cell Res (1985) 1.81

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. J Biol Chem (2003) 1.81

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle (2009) 1.79

Involvement of IL-32 in activation-induced cell death in T cells. Int Immunol (2006) 1.73

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. Cancer (2010) 1.70

Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases. Arthritis Res Ther (2006) 1.58

IL-32, a novel cytokine with a possible role in disease. Ann Rheum Dis (2006) 1.54

Endogenous IL-32 controls cytokine and HIV-1 production. J Immunol (2008) 1.47

Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes. Eur Cytokine Netw (2005) 1.44

Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Mol Cell Biol (1999) 1.42

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc Natl Acad Sci U S A (2008) 1.38

Interleukin-32 induces the differentiation of monocytes into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 1.37

Integrin targeted therapeutics. Theranostics (2011) 1.36

A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J Am Soc Nephrol (1999) 1.34

Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann Rheum Dis (2002) 1.34

Proteinase 3 is an IL-32 binding protein. Proc Natl Acad Sci U S A (2006) 1.32

IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.31

IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J Immunol (2010) 1.25

Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. PLoS One (2008) 1.24

IL-32-dependent effects of IL-1beta on endothelial cell functions. Proc Natl Acad Sci U S A (2009) 1.14

Interleukin-32 expression in the pancreas. J Biol Chem (2009) 1.14

Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype. Am J Respir Crit Care Med (2009) 1.14

IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol (2010) 1.13

Integrin inhibitors reaching the clinic. J Clin Oncol (2007) 1.12

Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann Rheum Dis (2010) 1.12

Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum (2009) 1.10

Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication. Immunol Lett (2008) 1.03

Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis. Proc Natl Acad Sci U S A (2011) 1.02

Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur J Immunol (2009) 1.01

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS One (2009) 0.99

Effect of interleukin-32gamma on differentiation of osteoclasts from CD14+ monocytes. Arthritis Rheum (2010) 0.97

Detection of expressed IL-32 in human stomach cancer using ELISA and immunostaining. J Microbiol Biotechnol (2008) 0.97

Cross talk between MyD88 and focal adhesion kinase pathways. J Immunol (2005) 0.94

Protection from RNA and DNA viruses by IL-32. J Immunol (2011) 0.94

IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2. Ann Rheum Dis (2010) 0.93

Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J Immunol (2008) 0.92

ERK 1/2- and JNKs-dependent synthesis of interleukins 6 and 8 by fibroblast-like synoviocytes stimulated with protein I/II, a modulin from oral streptococci, requires focal adhesion kinase. J Biol Chem (2003) 0.90

RGD peptide-induced cell death of chondrocytes and synovial cells. J Orthop Sci (2008) 0.88

Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein. Cytokine (2011) 0.88

Proteinase 3-processed form of the recombinant IL-32 separate domain. BMB Rep (2008) 0.87

Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer (2010) 0.85

Flipping the safety catch of procaspase-3. Nat Chem Biol (2006) 0.81

Direct activation of caspases by RGD-peptides may increase drug sensitivity of tumour cells. Drug Resist Updat (1999) 0.78

Development of defined media for the serum-free expansion of primary keratinocytes and human embryonic stem cells. Tissue Eng Part C Methods (2008) 0.77

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Hidden killers: human fungal infections. Sci Transl Med (2012) 7.10

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36

Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med (2009) 5.27

Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest (2006) 4.72

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood (2008) 4.63

Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum (2004) 4.58

Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ (2010) 4.44

Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation (2003) 4.09

Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med (2013) 3.81

IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A (2003) 3.80

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci U S A (2012) 3.62

Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med (2003) 3.54

Interleukin-32: a cytokine and inducer of TNFalpha. Immunity (2005) 3.39

IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol (2010) 3.27

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 3.11

STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med (2011) 3.11

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A (2009) 3.07

The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe (2009) 3.07

Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A (2011) 2.92

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut (2011) 2.91

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci U S A (2002) 2.91

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A (2014) 2.86

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med (2006) 2.86

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest (2008) 2.82

Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol (2011) 2.75

Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol (2011) 2.70

IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A (2006) 2.67

Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med (2013) 2.65

CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells. J Immunol (2005) 2.63

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol (2008) 2.62

Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res (2007) 2.62

The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A (2004) 2.61

IL-1beta processing in host defense: beyond the inflammasomes. PLoS Pathog (2010) 2.54

The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther (2004) 2.54

Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients. Clin Infect Dis (2009) 2.49

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46

Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis. Sci Transl Med (2012) 2.46

Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum (2007) 2.42

Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc Natl Acad Sci U S A (2004) 2.41

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease. Proc Natl Acad Sci U S A (2010) 2.38

The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol (2003) 2.30

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3. J Immunol (2009) 2.28

TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A (2007) 2.28

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. Am J Pathol (2005) 2.26

IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol (2011) 2.25

Immune recognition of Candida albicans beta-glucan by dectin-1. J Infect Dis (2007) 2.24

Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest (2008) 2.23

Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum (2009) 2.23

Planning the human variome project: the Spain report. Hum Mutat (2009) 2.22

Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med (2007) 2.18

The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res (2007) 2.15

Rapid responses to anakinra in patients with refractory adult-onset Still's disease. Arthritis Rheum (2005) 2.13

Osteophytes: relevance and biology. Osteoarthritis Cartilage (2007) 2.12

The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med (2006) 2.11

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cell Microbiol (2008) 2.11

Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol (2006) 2.09

The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol (2008) 2.08

Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci U S A (2011) 2.06

Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc Natl Acad Sci U S A (2010) 2.04

NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog (2005) 2.04

Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med (2006) 2.04

Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum (2004) 2.03

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. J Hepatol (2011) 2.02

CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J Clin Invest (2013) 2.00

A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol (2009) 2.00

Toll-like receptor 2 controls acute immune complex-driven arthritis in mice by regulating the inhibitory Fcγ receptor IIB. Arthritis Rheum (2013) 2.00