PubRank

Kornelia Polyak

Author PubWeight™ 285.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008 46.08
2 The genomic landscapes of human breast and colorectal cancers. Science 2007 38.12
3 Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007 15.20
4 Molecular definition of breast tumor heterogeneity. Cancer Cell 2007 12.67
5 Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004 9.41
6 Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 2012 7.76
7 Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007 7.60
8 Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 2012 6.82
9 Ductal carcinoma in situ of the breast. N Engl J Med 2004 6.63
10 Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 2009 5.90
11 Profiling critical cancer gene mutations in clinical tumor samples. PLoS One 2009 5.63
12 Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A 2011 5.53
13 Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 2008 4.46
14 An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A 2002 4.45
15 The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest 2011 4.41
16 Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet 2005 4.33
17 Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest 2010 4.22
18 No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 2008 3.32
19 Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res 2010 3.19
20 Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 2005 3.19
21 Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle 2007 3.01
22 Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A 2008 2.99
23 Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol 2012 2.56
24 Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res 2003 2.55
25 An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res 2009 2.37
26 Microenvironmental regulation of cancer development. Curr Opin Genet Dev 2008 2.25
27 The microenvironment in breast cancer progression: biology and implications for treatment. Breast Cancer Res 2011 2.22
28 DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int J Cancer 2003 2.18
29 Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell 2009 2.15
30 Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov 2012 2.01
31 Genetic and phenotypic diversity in breast tumor metastases. Cancer Res 2014 1.96
32 Genome-wide functional synergy between amplified and mutated genes in human breast cancer. Cancer Res 2008 1.82
33 Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci U S A 2009 1.81
34 Identifying tumor origin using a gene expression-based classification map. Cancer Res 2003 1.78
35 The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell 2013 1.75
36 Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer Res 2006 1.74
37 Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 2013 1.73
38 RNA sequencing of cancer reveals novel splicing alterations. Sci Rep 2013 1.57
39 The origins and implications of intratumor heterogeneity. Cancer Prev Res (Phila) 2010 1.55
40 PIK3CA mutations in in situ and invasive breast carcinomas. Cancer Res 2010 1.49
41 Cancer stem cells: a model in the making. Curr Opin Genet Dev 2009 1.48
42 The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab Invest 2008 1.47
43 Gene expression profiling of human breast tissue samples using SAGE-Seq. Genome Res 2010 1.41
44 A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A 2003 1.41
45 Molecular characterisation of the tumour microenvironment in breast cancer. Eur J Cancer 2008 1.39
46 Cellular and molecular targets of estrogen in normal human breast tissue. Cancer Res 2002 1.35
47 Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. Clin Cancer Res 2004 1.35
48 Stem cells in the human breast. Cold Spring Harb Perspect Biol 2010 1.33
49 Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res 2008 1.31
50 Cancer chromosomes in crisis. Nat Genet 2004 1.30
51 Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res 2002 1.29
52 Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression). Oncogene 2002 1.27
53 Origin of carcinoma associated fibroblasts. Cell Cycle 2009 1.22
54 Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution. Cancer Res 2009 1.21
55 A putative role for psoriasin in breast tumor progression. Cancer Res 2005 1.19
56 Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium. PLoS Genet 2011 1.15
57 PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One 2010 1.15
58 Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics. Cell Stem Cell 2013 1.14
59 HIN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res 2005 1.13
60 Epigenetic patterns of embryonic and adult stem cells. Cell Cycle 2009 1.13
61 Breast-cancer stromal cells with TP53 mutations. N Engl J Med 2008 1.10
62 Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. Mol Cancer Res 2004 1.10
63 Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. Clin Cancer Res 2004 1.10
64 Altered antisense-to-sense transcript ratios in breast cancer. Proc Natl Acad Sci U S A 2010 1.08
65 Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers. Genes Chromosomes Cancer 2012 1.06
66 Targeting Akt3 signaling in triple-negative breast cancer. Cancer Res 2013 1.06
67 The challenges posed by cancer heterogeneity. Nat Biotechnol 2012 1.05
68 The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium. Proc Natl Acad Sci U S A 2011 1.02
69 Cancer. Cancer cell phenotypes, in fifty shades of grey. Science 2013 1.02
70 Targeting the missing links for cancer therapy. Nat Med 2011 0.99
71 Psoriasin (S100A7) and calgranulin-B (S100A9) induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants. Cancer Biol Ther 2005 0.98
72 Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies. Lab Invest 2009 0.98
73 S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation. PLoS One 2008 0.97
74 Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues. Mech Dev 2002 0.97
75 Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors. Cancer Res 2003 0.91
76 Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis. J Pathol 2013 0.90
77 Cyclooxygenase-2 expression during immortalization and breast cancer progression. Cancer Res 2008 0.88
78 Serial analysis of gene expression. Nat Protoc 2006 0.88
79 Deconvoluting complex tissues for expression quantitative trait locus-based analyses. Philos Trans R Soc Lond B Biol Sci 2013 0.87
80 A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force. Cancer Res 2012 0.87
81 Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res 2008 0.87
82 SAGE and related approaches for cancer target identification. Drug Discov Today 2006 0.86
83 Methylation-specific digital karyotyping. Nat Protoc 2006 0.84
84 Functional synergies yet distinct modulators affected by genetic alterations in common human cancers. Cancer Res 2011 0.83
85 Tracking tumor resistance using 'liquid biopsies'. Nat Med 2013 0.82
86 Cancer target discovery using SAGE. Expert Opin Ther Targets 2003 0.81
87 Tumor heterogeneity: the Lernaean hydra of oncology? Oncology (Williston Park) 2014 0.80
88 Serial analysis of gene expression (SAGE): experimental method and data analysis. Curr Protoc Mol Biol 2007 0.80
89 The expression of Psoriasin (S100A7) and CD24 is linked and related to the differentiation of mammary epithelial cells. PLoS One 2012 0.80
90 Unraveling the complexity of basal-like breast cancer. Oncotarget 2011 0.79
91 EMSY links breast cancer gene 2 to the 'Royal Family'. Breast Cancer Res 2004 0.79
92 Serial analysis of gene expression (SAGE): experimental method and data analysis. Curr Protoc Hum Genet 2007 0.76
93 Going small is the new big. Nat Methods 2010 0.75