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Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast. Oncogene (2010) 1.47

Understanding the role of stromal fibroblasts in cancer progression. Cell Adh Migr (2012) 1.27

Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy? Semin Cell Dev Biol (2009) 1.23

Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies. Mol Cancer (2009) 1.17

Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors. Proc Natl Acad Sci U S A (2012) 1.17

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res (2010) 1.12

Cancer cells suppress p53 in adjacent fibroblasts. Oncogene (2008) 1.10

Mutations in bone marrow-derived stromal stem cells unmask latent malignancy. Stem Cells Dev (2010) 1.05

Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts. Neoplasia (2013) 0.98

Roles of tumor suppressors in regulating tumor-associated inflammation. Cell Death Differ (2014) 0.89

Involvement of stromal p53 in tumor-stroma interactions. Semin Cell Dev Biol (2009) 0.87

2-methoxyestradiol inhibits Barrett's esophageal adenocarcinoma growth and differentiation through differential regulation of the beta-catenin-E-cadherin axis. Mol Cancer Ther (2010) 0.83

Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression. Semin Cancer Biol (2017) 0.75

Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med (2007) 6.47

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

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Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res (2008) 8.17

Sequence analysis of mutations and translocations across breast cancer subtypes. Nature (2012) 7.76

Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60

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Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 5.63

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53

Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46

An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A (2002) 4.45

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41

Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet (2005) 4.33

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest (2010) 4.22

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet (2008) 3.32

Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res (2010) 3.19

Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med (2005) 3.19

Co-evolution of tumor cells and their microenvironment. Trends Genet (2008) 3.08

Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle (2007) 3.01

Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99

CONTRA: copy number analysis for targeted resequencing. Bioinformatics (2012) 2.64

Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol (2012) 2.56

Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res (2003) 2.55

An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res (2009) 2.37

Microenvironmental regulation of cancer development. Curr Opin Genet Dev (2008) 2.25

The microenvironment in breast cancer progression: biology and implications for treatment. Breast Cancer Res (2011) 2.22

DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int J Cancer (2003) 2.18

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell (2009) 2.15

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA (2011) 2.03

Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov (2012) 2.01

Genetic and phenotypic diversity in breast tumor metastases. Cancer Res (2014) 1.96

Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res (2003) 1.88

is-rSNP: a novel technique for in silico regulatory SNP detection. Bioinformatics (2010) 1.84

Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles. PLoS Genet (2012) 1.84

Genome-wide functional synergy between amplified and mutated genes in human breast cancer. Cancer Res (2008) 1.82

Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci U S A (2009) 1.81

High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications. Clin Cancer Res (2007) 1.81

IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clin Cancer Res (2011) 1.79

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. J Clin Invest (2012) 1.79

Identifying tumor origin using a gene expression-based classification map. Cancer Res (2003) 1.78

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell (2013) 1.75

Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer Res (2006) 1.74

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell (2013) 1.73

Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypotheses. Mol Cell Endocrinol (2005) 1.65

Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis. PLoS One (2010) 1.60

RNA sequencing of cancer reveals novel splicing alterations. Sci Rep (2013) 1.57

The origins and implications of intratumor heterogeneity. Cancer Prev Res (Phila) (2010) 1.55

The maturational trajectories of NREM and REM sleep durations differ across adolescence on both school-night and extended sleep. Am J Physiol Regul Integr Comp Physiol (2011) 1.54

An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Res (2005) 1.52

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Oncogene (2004) 1.51

Copy number analysis identifies novel interactions between genomic loci in ovarian cancer. PLoS One (2010) 1.50

PIK3CA mutations in in situ and invasive breast carcinomas. Cancer Res (2010) 1.49

Cancer stem cells: a model in the making. Curr Opin Genet Dev (2009) 1.48

The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab Invest (2008) 1.47

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". PLoS Genet (2010) 1.47

Gene expression profiling of human breast tissue samples using SAGE-Seq. Genome Res (2010) 1.41

A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A (2003) 1.41

Plasma lipidomic analysis of stable and unstable coronary artery disease. Arterioscler Thromb Vasc Biol (2011) 1.39

Molecular characterisation of the tumour microenvironment in breast cancer. Eur J Cancer (2008) 1.39

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. Hum Mutat (2011) 1.38

Sleep EEG changes during adolescence: an index of a fundamental brain reorganization. Brain Cogn (2009) 1.38

The adolescent decline of NREM delta, an indicator of brain maturation, is linked to age and sex but not to pubertal stage. Am J Physiol Regul Integr Comp Physiol (2006) 1.36

Cellular and molecular targets of estrogen in normal human breast tissue. Cancer Res (2002) 1.35

Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. Clin Cancer Res (2004) 1.35

Stem cells in the human breast. Cold Spring Harb Perspect Biol (2010) 1.33

Prediction of breast cancer prognosis using gene set statistics provides signature stability and biological context. BMC Bioinformatics (2010) 1.33

Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res (2008) 1.31

Are there any more ovarian tumor suppressor genes? A new perspective using ultra high-resolution copy number and loss of heterozygosity analysis. Genes Chromosomes Cancer (2009) 1.31

Cancer chromosomes in crisis. Nat Genet (2004) 1.30

Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res (2002) 1.29

Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties. Clin Exp Metastasis (2004) 1.29

Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression). Oncogene (2002) 1.27

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. Cancer Res (2006) 1.26

Genome-wide, high-resolution detection of copy number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded tumor tissue using microarrays. Cancer Res (2007) 1.25

Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer. Neoplasia (2008) 1.23

EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene (2003) 1.23

Origin of carcinoma associated fibroblasts. Cell Cycle (2009) 1.22

The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study. Breast Cancer Res (2004) 1.22

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome Res (2011) 1.22

Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution. Cancer Res (2009) 1.21

RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. J Pathol (2013) 1.20

A putative role for psoriasin in breast tumor progression. Cancer Res (2005) 1.19

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol Cell Biol (2002) 1.18

Whole genome SNP arrays using DNA derived from formalin-fixed, paraffin-embedded ovarian tumor tissue. Hum Mutat (2005) 1.15

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium. PLoS Genet (2011) 1.15

PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One (2010) 1.15

Mutation analysis of EP300 in colon, breast and ovarian carcinomas. Int J Cancer (2002) 1.15

Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics. Cell Stem Cell (2013) 1.14