Published in Cancer Cell on July 01, 2003
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet (2005) 2.92
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res (2006) 1.81
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol (2004) 1.47
Activation of Rap1 promotes prostate cancer metastasis. Cancer Res (2009) 1.41
Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood (2005) 1.33
Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Am J Pathol (2006) 1.26
Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res (2007) 1.22
Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. J Clin Invest (2005) 1.18
Downregulation of Rap1GAP contributes to Ras transformation. Mol Cell Biol (2007) 1.16
PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia. Proc Natl Acad Sci U S A (2009) 1.14
Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras. J Virol (2004) 1.10
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol (2010) 1.03
Loss of Rap1GAP in papillary thyroid cancer. J Clin Endocrinol Metab (2008) 1.02
Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. J Immunol (2008) 1.01
Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues. Immunology (2005) 0.98
Unravelling the mechanism of dual-specificity GAPs. EMBO J (2010) 0.96
Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proc Natl Acad Sci U S A (2003) 0.92
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. BMC Biochem (2006) 0.91
Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. Blood (2010) 0.88
Mouse models as tools to understand and study BCR-ABL1 diseases. Am J Blood Res (2011) 0.88
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RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood (2010) 0.84
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem (2014) 0.84
A bad rap: Rap1 signaling and oncogenesis. Cancer Cell (2003) 0.83
Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. Endocr Relat Cancer (2011) 0.81
Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia. Sci Rep (2015) 0.80
The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood (2016) 0.79
Cortex Mori Radicis Extract induces neurite outgrowth in PC12 cells activating ERK signaling pathway via inhibiting Ca(2+) influx. Int J Clin Exp Med (2015) 0.77
The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention. Acta Biochim Biophys Sin (Shanghai) (2015) 0.77
Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells. PLoS One (2015) 0.75
Rap signaling in normal lymphocyte development and leukemia genesis. Immune Netw (2009) 0.75
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A (2002) 12.39
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature (2009) 9.71
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity (2009) 9.01
NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood (2002) 7.78
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A (2007) 7.49
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science (2003) 5.05
A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J (2006) 4.95
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood (2002) 4.88
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol (2002) 4.66
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci (2007) 4.34
Frequent inactivation of A20 in B-cell lymphomas. Nature (2009) 4.22
Innate versus learned odour processing in the mouse olfactory bulb. Nature (2007) 4.19
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
Generation of pluripotent stem cells from neonatal mouse testis. Cell (2004) 3.95
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature (2011) 3.77
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science (2002) 3.58
Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med (2002) 3.55
Adult T-cell progenitors retain myeloid potential. Nature (2008) 3.41
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Constitutive expression of AID leads to tumorigenesis. J Exp Med (2003) 3.16
A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting. Cell (2006) 3.15
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One (2010) 3.09
Odorant receptor-derived cAMP signals direct axonal targeting. Science (2006) 3.03
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. Nature (2008) 2.94
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci (2006) 2.87
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett (2002) 2.80
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med (2003) 2.65
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood (2003) 2.53
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc Natl Acad Sci U S A (2005) 2.49
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest (2007) 2.45
Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J Immunol (2009) 2.44
Pre-target axon sorting establishes the neural map topography. Science (2009) 2.42
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet (2007) 2.39
Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity (2004) 2.37
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. Blood (2004) 2.32
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell (2013) 2.32
Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci U S A (2010) 2.27
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci (2002) 2.25
Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity (2007) 2.23
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J (2004) 2.22
Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function. J Biol Chem (2005) 2.21
Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell (2005) 2.21
E3 ubiquitin ligase that recognizes sugar chains. Nature (2002) 2.17
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. Mol Biol Cell (2008) 2.14
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron (2005) 2.11
E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J Exp Med (2006) 2.11
Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett (2003) 2.10
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A (2008) 2.03
An essential developmental checkpoint for production of the T cell lineage. Science (2010) 2.01
Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells. Blood (2007) 2.00
Effects of CB-VEGF-A injection in rat flap models for improved survival. Plast Reconstr Surg (2013) 1.99
Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation. Pediatr Transplant (2008) 1.99
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe (2012) 1.93
Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli. Mol Microbiol (2004) 1.91
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development (2003) 1.90
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol (2008) 1.89
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell (2007) 1.82
Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion. Proc Natl Acad Sci U S A (2013) 1.82
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation (2004) 1.80
Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells. Cell Stem Cell (2013) 1.79
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol (2005) 1.79
Rap1 GTPase: functions, regulation, and malignancy. J Biochem (2003) 1.78
Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone. Proc Natl Acad Sci U S A (2005) 1.77
Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis. Proc Natl Acad Sci U S A (2008) 1.75
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab (2011) 1.74
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice. Hum Mol Genet (2002) 1.73
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med (2009) 1.72
The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. J Immunol (2002) 1.71
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Discov (2014) 1.70
Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci U S A (2011) 1.69
Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients. Blood (2007) 1.69
Neonatal diabetes mellitus and neonatal polycystic, dysplastic kidneys: Phenotypically discordant recurrence of a mutation in the hepatocyte nuclear factor-1beta gene due to germline mosaicism. J Clin Endocrinol Metab (2004) 1.67
Generation and physiological roles of linear ubiquitin chains. BMC Biol (2012) 1.66
Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol (2005) 1.66