Published in Proc Natl Acad Sci U S A on September 08, 2009
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med (2012) 2.58
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol (2013) 2.50
Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J Immunol (2012) 1.25
Intracellular osteopontin (iOPN) and immunity. Immunol Res (2011) 1.23
The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia. Haematologica (2013) 1.21
T cell metabolic fitness in antitumor immunity. Trends Immunol (2015) 1.12
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway. Aging Cell (2010) 1.12
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun (2014) 1.00
Impaired selection of IgA and intestinal dysbiosis associated with PD-1-deficiency. Gut Microbes (2013) 0.93
Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. PLoS One (2012) 0.93
Immunotherapy for prostate cancer: biology and therapeutic approaches. J Clin Oncol (2011) 0.91
Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction. Aging Cell (2011) 0.90
Optimization of immunotherapy in elderly cancer patients. Crit Rev Oncog (2013) 0.90
CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nat Immunol (2016) 0.89
Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One (2011) 0.89
Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor. FASEB J (2013) 0.84
HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling. Retrovirology (2013) 0.83
Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection. J Virol (2010) 0.83
Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest (2016) 0.82
Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model. Br J Haematol (2015) 0.79
Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity. Cell Rep (2016) 0.77
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. Front Oncol (2017) 0.75
Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight (2016) 0.75
Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines. PLoS One (2015) 0.75
C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner. PLoS One (2014) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04
Age-related changes in lymphocyte development and function. Nat Immunol (2004) 6.16
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet (2006) 5.62
The PD-1-PD-L pathway in immunological tolerance. Trends Immunol (2006) 4.52
Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95
Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity (2004) 3.84
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol (2003) 3.82
Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med (2003) 3.76
Homeostasis of memory T cells. Immunol Rev (2006) 3.69
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol (2006) 3.21
Osteopontin: role in immune regulation and stress responses. Cytokine Growth Factor Rev (2008) 3.06
Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J Immunol (2005) 2.73
Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity (2006) 2.58
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci (2005) 2.57
The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol (2000) 2.52
The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev (2000) 2.49
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity (2007) 2.23
Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med (2004) 2.23
Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest (2005) 2.15
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell (2003) 2.11
Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell (2003) 1.98
Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J Immunol (2002) 1.85
Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol (1997) 1.84
T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A (2005) 1.83
IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A (2004) 1.79
Ageing of lymphocytes and lymphocytes in the aged. Immunol Today (2000) 1.65
The regulation and role of osteopontin in malignant transformation and cancer. Cytokine Growth Factor Rev (2006) 1.59
Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J Exp Med (2005) 1.59
Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice. J Immunol (2001) 1.42
Early activation defects in T lymphocytes from aged mice. Immunol Rev (1997) 1.38
Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proc Natl Acad Sci U S A (2003) 0.92
Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus-afflicted mice. Exp Gerontol (2000) 0.81
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A (2002) 12.39
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A (2007) 7.49
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett (2002) 2.80
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal (2007) 2.77
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med (2003) 2.65
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet (2007) 2.39
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell (2003) 2.11
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A (2008) 2.03
Effects of CB-VEGF-A injection in rat flap models for improved survival. Plast Reconstr Surg (2013) 1.99
Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. Blood (2011) 1.88
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol (2005) 1.79
Rap1 GTPase: functions, regulation, and malignancy. J Biochem (2003) 1.78
Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone. Proc Natl Acad Sci U S A (2005) 1.77
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med (2007) 1.64
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Nat Cell Biol (2003) 1.61
Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes. Cancer Res (2004) 1.60
Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study. Cancer Immunol Immunother (2006) 1.59
Decreased death from gastric cancer by endoscopic screening: association with a population-based cancer registry. Scand J Gastroenterol (2008) 1.52
Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol (2004) 1.47
Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses. Mol Cell Biol (2002) 1.46
Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells (2007) 1.41
Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant (2004) 1.40
Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway. Cardiovasc Res (2010) 1.39
Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun (2013) 1.36
Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab Res Rev (2002) 1.31
Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transpl Immunol (2006) 1.28
AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem (2003) 1.28
Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma. Cancer Immunol Immunother (2011) 1.18
Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett (2004) 1.18
Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis. Gastric Cancer (2005) 1.15
Requirement of species-specific interactions for the activation of human gamma delta T cells by pamidronate. J Immunol (2003) 1.15
Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice. Diabetes (2003) 1.15
Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J (2005) 1.14
Difference in accuracy between gastroscopy and colonoscopy for detection of cancer. Hepatogastroenterology (2007) 1.11
T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells. J Immunol (2003) 1.09
Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood (2003) 1.05
Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. Anticancer Res (2010) 1.04
Expression and function of PD-1 in human γδ T cells that recognize phosphoantigens. Eur J Immunol (2011) 1.03
Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Immunity (2006) 1.03
Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J Immunol (2010) 1.02
A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome. Atherosclerosis (2008) 1.01
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. Mol Cell Biol (2009) 1.00
Recognition mechanism of non-peptide antigens by human gammadelta T cells. Int Immunol (2003) 0.99
Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineages. J Immunol (2005) 0.98
Progranulin expression in advanced human atherosclerotic plaque. Atherosclerosis (2009) 0.98
Isolation of ON bipolar cell genes via hrGFP-coupled cell enrichment using the mGluR6 promoter. J Biochem (2009) 0.97
CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. Arterioscler Thromb Vasc Biol (2008) 0.95
Rap1 and SPA-1 in hematologic malignancy. Trends Mol Med (2004) 0.95
Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells. Cancer Immunol Immunother (2012) 0.95
T cell lineage determination precedes the initiation of TCR beta gene rearrangement. J Immunol (2007) 0.95
Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. PLoS One (2012) 0.93
[A case of advanced gastric cancer with tumor embolus in the portal vein successfully treated with S-1 and CDDP therapy]. Gan To Kagaku Ryoho (2011) 0.92
Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proc Natl Acad Sci U S A (2003) 0.92
Metallo-allixinate complexes with anti-diabetic and anti-metabolic syndrome activities. Metallomics (2010) 0.91
CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway. Biochem Biophys Res Commun (2007) 0.89
Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection. Microbes Infect (2006) 0.89
Long-term survival and conditional survival of cancer patients in Japan using population-based cancer registry data. Cancer Sci (2014) 0.88
Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci Technol Adv Mater (2013) 0.87
Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development. Stem Cells (2011) 0.87
Regulation of immune responses and hematopoiesis by the Rap1 signal. Adv Immunol (2007) 0.86
Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon. Development (2011) 0.86
SPA-1 controls the invasion and metastasis of human prostate cancer. Cancer Sci (2011) 0.86
Hybrid single-incision laparoscopic sigmoidectomy: the effective use of small incision. J Laparoendosc Adv Surg Tech A (2011) 0.85
Short-term projection of cancer incidence in Japan using an age-period interaction model with spline smoothing. Jpn J Clin Oncol (2013) 0.85
Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome. Circ J (2008) 0.85
Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Sci (2008) 0.85
Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome. Liver Transpl (2006) 0.85
E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus. J Immunol (2012) 0.85
Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens. J Immunol (2006) 0.85
Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development. Blood (2008) 0.85
Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling. Blood (2008) 0.84
Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. Cancer Sci (2013) 0.84
Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency. Cancer Sci (2011) 0.84
Sexually dichromatic protogynous angelfish Centropyge ferrugata (Pomacanthidae) males can change back to females. Zoolog Sci (2003) 0.83
Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome. Clin J Am Soc Nephrol (2010) 0.83
[Investigation of epiphora following S-1 therapy]. Gan To Kagaku Ryoho (2011) 0.83