Published in Mol Aspects Med on August 01, 2003
Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest (2005) 2.34
Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem (2008) 2.09
Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. Diabetes (2010) 1.70
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med (2008) 1.23
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Arch Biochem Biophys (2008) 1.10
4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy. Neurotox Res (2009) 1.05
4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways. Free Radic Biol Med (2005) 1.05
Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine (2006) 1.05
Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease. Redox Biol (2013) 1.04
Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry (2010) 1.01
Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. Biochemistry (2010) 1.00
Lipid peroxidation and decomposition--conflicting roles in plaque vulnerability and stability. Biochim Biophys Acta (2008) 1.00
Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. J Lipid Res (2008) 0.99
4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry (2007) 0.97
Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis. Arthritis Res Ther (2012) 0.97
The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic Biol Med (2007) 0.97
Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. Antioxid Redox Signal (2010) 0.96
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol (2006) 0.96
RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci (2005) 0.94
Lipid peroxidation-mediated inflammation promotes cell apoptosis through activation of NF-κB pathway in rheumatoid arthritis synovial cells. Mediators Inflamm (2015) 0.94
Reactive carbonyl species in vivo: generation and dual biological effects. ScientificWorldJournal (2014) 0.93
LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. Cell Death Differ (2014) 0.90
Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappaB translocation. Toxicol Appl Pharmacol (2008) 0.89
Past, present and future therapeutics for cerebellar ataxias. Curr Neuropharmacol (2010) 0.88
Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. Arch Biochem Biophys (2007) 0.88
High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner. Free Radic Biol Med (2013) 0.88
Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvasc Res (2011) 0.88
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. Free Radic Biol Med (2009) 0.86
Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways. PLoS One (2012) 0.86
Differential Role of ERK and p38 on NF- κ B Activation in Helicobacter pylori-Infected Gastric Epithelial Cells. J Cancer Prev (2013) 0.85
Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress. Invest Ophthalmol Vis Sci (2008) 0.84
4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. J Biol Chem (2013) 0.83
A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases. Expert Opin Investig Drugs (2012) 0.83
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling. Toxicol Appl Pharmacol (2015) 0.82
Gsta4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity. Open J Apoptosis (2013) 0.82
Regulation of signal transduction by glutathione transferases. Int J Hepatol (2012) 0.82
The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products. PPAR Res (2008) 0.81
Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia. Sci Rep (2016) 0.81
Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget (2016) 0.80
Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin. Arch Biochem Biophys (2006) 0.79
Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane. Free Radic Biol Med (2012) 0.78
Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts. Transplantation (2010) 0.77
4-Hydroxy-2-nonenal induces apoptosis by inhibiting AKT signaling in human osteosarcoma cells. ScientificWorldJournal (2014) 0.77
Melatonin affects conjugation of 4-hydroxynonenal with glutathione in liver of pacu, a hypoxia-tolerant fish. Fish Physiol Biochem (2013) 0.76
Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress. Med Sci Monit (2011) 0.75
Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells. Neural Regen Res (2016) 0.75
Afferent regulation of oxidative stress in the chick cochlear nucleus. Neuroscience (2006) 0.75
Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity. Free Radic Biol Med (2016) 0.75
Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study. Lancet Oncol (2011) 3.66
High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV study. Am J Clin Pathol (2011) 3.49
Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16/18: results from the ATHENA HPV study. Am J Obstet Gynecol (2012) 2.38
The interplay of age stratification and HPV testing on the predictive value of ASC-US cytology. Results from the ATHENA HPV study. Am J Clin Pathol (2012) 1.79
Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results. Am J Clin Pathol (2011) 1.72
Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim Pol (2003) 1.67
Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prev Res (Phila) (2011) 1.44
Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. J Biol Chem (2001) 1.43
Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic Biol Med (2004) 1.40
Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Res (2007) 1.39
RLIP76 is a major determinant of radiation sensitivity. Cancer Res (2005) 1.37
Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol (2004) 1.36
Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal (2004) 1.33
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol (2005) 1.32
Regression of melanoma in a murine model by RLIP76 depletion. Cancer Res (2006) 1.31
Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int J Cancer (2003) 1.30
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res (2006) 1.27
Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. J Biol Chem (2008) 1.26
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med (2008) 1.23
Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol (2005) 1.21
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer. Cancer Res (2005) 1.16
Role of 4-hydroxynonenal and its metabolites in signaling. Redox Rep (2007) 1.15
Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses. Biochemistry (2004) 1.12
RLIP76 in defense of radiation poisoning. Int J Radiat Oncol Biol Phys (2008) 1.10
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Arch Biochem Biophys (2008) 1.10
Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer (2010) 1.10
Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. J Biol Chem (2003) 1.10
Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. Biochemistry (2006) 1.09
The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors. Int J Cancer (2010) 1.08
RLIP76 and Cancer. Clin Cancer Res (2008) 1.07
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol (2003) 1.06
Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Cancer Metastasis Rev (2007) 1.05
Lower genital tract infections in HIV-seropositive women in India. Indian J Sex Transm Dis (2011) 1.04
RLIP76: a target for kidney cancer therapy. Cancer Res (2009) 1.03
Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. FEBS Lett (2006) 1.02
Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol (2006) 1.02
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol (2003) 1.01
Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry (2010) 1.01
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Int J Oncol (2003) 1.01
Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. Biochemistry (2010) 1.00
Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences. Biochemistry (2001) 0.99
RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab Dispos (2002) 0.99
Interlaboratory variation in the performance of liquid-based cytology: insights from the ATHENA trial. Int J Cancer (2013) 0.99
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Int J Cancer (2004) 0.99
RLIP76: a versatile transporter and an emerging target for cancer therapy. Biochem Pharmacol (2010) 0.97
4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry (2007) 0.97
Regression of prostate cancer xenografts by RLIP76 depletion. Biochem Pharmacol (2008) 0.96
Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products. J Biol Chem (2001) 0.96
Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis (2004) 0.95
The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice. Toxicology (2005) 0.95
Study on prevalence of needle stick injury among health care workers in a tertiary care hospital in New Delhi: a two-year review. Indian J Public Health (2012) 0.94
POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Biochem Biophys Res Commun (2005) 0.94
RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci (2005) 0.94
Role of RLIP76 in doxorubicin resistance in lung cancer. Int J Oncol (2009) 0.94
Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. J Neurochem (2002) 0.93
Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem (2004) 0.93
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis. Mol Cancer Ther (2011) 0.93