Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.

PubWeight™: 1.70‹?› | Rank: Top 3%

🔗 View Article (PMC 2857893)

Published in Diabetes on February 11, 2010

Authors

Jessica M Curtis1, Paul A Grimsrud, Wendy S Wright, Xin Xu, Rocio E Foncea, David W Graham, Jonathan R Brestoff, Brian M Wiczer, Olga Ilkayeva, Katherine Cianflone, Deborah E Muoio, Edgar A Arriaga, David A Bernlohr

Author Affiliations

1: Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota, Minneapolis, Minnesota, USA.

Associated clinical trials:

Mitochondrial Energy Metabolism in Obese Women | NCT03119350

Articles citing this

Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes (2013) 2.25

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med (2012) 2.13

S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49

Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35

Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab (2012) 1.35

Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes (2011) 1.34

Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease. FEBS J (2011) 1.32

Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab (2012) 1.22

Immune regulation of metabolic homeostasis in health and disease. Cell (2015) 1.21

Oxidative stress and metabolic pathologies: from an adipocentric point of view. Oxid Med Cell Longev (2014) 1.16

Glutathione and mitochondria. Front Pharmacol (2014) 1.08

Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab (2014) 1.06

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Redox Biol (2015) 1.02

Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes (2013) 1.01

Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size. J Clin Endocrinol Metab (2013) 0.98

A comparison of inflammatory and oxidative stress markers in adipose tissue from weight-matched obese male and female mice. Exp Diabetes Res (2012) 0.96

Relation between serum free fatty acids and adiposity, insulin resistance, and cardiovascular risk factors from adolescence to adulthood. Diabetes (2013) 0.96

Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks. Sci Rep (2013) 0.94

Protein carbonylation, mitochondrial dysfunction, and insulin resistance. Adv Nutr (2013) 0.93

Protein carbonylation and adipocyte mitochondrial function. J Biol Chem (2012) 0.93

4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin-proteasome degradation. Mol Cell Endocrinol (2011) 0.93

Comparative Analysis of Serum (Anti)oxidative Status Parаmeters in Healthy Persons. Int J Mol Sci (2013) 0.92

Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2. Mol Cell Biol (2015) 0.91

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats. FASEB J (2014) 0.91

Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes. Autophagy (2013) 0.90

Protein carbonylation and metabolic control systems. Trends Endocrinol Metab (2012) 0.90

High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner. Free Radic Biol Med (2013) 0.88

Oxidative stress and protein carbonylation in adipose tissue - implications for insulin resistance and diabetes mellitus. J Proteomics (2013) 0.88

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab (2014) 0.88

Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation. Diabetes (2013) 0.87

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase. Biochem Biophys Res Commun (2013) 0.87

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol (2016) 0.86

Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J Pathol (2012) 0.83

Oxidative stress and nitric oxide signaling related biomarkers in patients with pulmonary hypertension: a case control study. BMC Pulm Med (2015) 0.83

Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3. Mol Endocrinol (2016) 0.81

A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids. Free Radic Biol Med (2013) 0.81

ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress. Am J Physiol Heart Circ Physiol (2014) 0.81

Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process? Antioxidants (Basel) (2016) 0.79

Glutathionylated products of lipid peroxidation: A novel mechanism of adipocyte to macrophage signaling. Adipocyte (2014) 0.79

Integrated Haematological Profiles of Redox Status, Lipid, and Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity with Metabolic Syndrome. Oxid Med Cell Longev (2015) 0.79

Raphanus sativus cv. Sango Sprout Juice Decreases Diet-Induced Obesity in Sprague Dawley Rats and Ameliorates Related Disorders. PLoS One (2016) 0.79

Oxidative stress and lipotoxicity. J Lipid Res (2016) 0.77

Emerging role of protein kinase C in energy homeostasis: A brief overview. World J Diabetes (2014) 0.77

Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol (2015) 0.77

Capillary electrophoretic analysis of hydroxyl radicals produced by respiring mitochondria. Anal Bioanal Chem (2013) 0.77

Critical evaluation of ayurvedic plants for stimulating intrinsic antioxidant response. Front Neurosci (2012) 0.77

Exercise and mitochondrial function in adipose biology: all roads lead to NO. Diabetes (2014) 0.76

Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue. Obes Surg (2015) 0.76

The Genetic Architecture of Murine Glutathione Transferases. PLoS One (2016) 0.75

Testosterone Deficiency Induces Changes of the Transcriptomes of Visceral Adipose Tissue in Miniature Pigs Fed a High-Fat and High-Cholesterol Diet. Int J Mol Sci (2016) 0.75

Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation. Mol Cell Neurosci (2017) 0.75

Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes. FEBS Open Bio (2014) 0.75

Correlative studies on the effects of obesity, diabetes and hypertension on gene expression in omental adipose tissue of obese women. Nutr Diabetes (2011) 0.75

Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity. PLoS One (2016) 0.75

Effect of Cross-Sex Hormonal Replacement on Antioxidant Enzymes in Rat Retroperitoneal Fat Adipocytes. Oxid Med Cell Longev (2016) 0.75

Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. Oxid Med Cell Longev (2017) 0.75

Manganese [III] Tetrakis [5,10,15,20]-Benzoic Acid Porphyrin Reduces Adiposity and Improves Insulin Action in Mice with Pre-Existing Obesity. PLoS One (2015) 0.75

Cafeteria diet-induced obesity causes oxidative damage in white adipose. Biochem Biophys Res Commun (2016) 0.75

High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes. Genes Nutr (2014) 0.75

Amelioration of mitochondrial dysfunction-induced insulin resistance in differentiated 3T3-L1 adipocytes via inhibition of NF-κB pathways. Int J Mol Sci (2014) 0.75

Cutting Calories and TXNIP From the Skeletal Muscle to Restore Insulin Sensitivity. Diabetes (2016) 0.75

The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity. Adipocyte (2017) 0.75

Articles cited by this

Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88

Prevalence of overweight and obesity in the United States, 1999-2004. JAMA (2006) 72.59

Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest (2004) 13.42

Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature (2006) 10.07

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74

Diet-induced type II diabetes in C57BL/6J mice. Diabetes (1988) 6.26

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest (2009) 5.66

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes (2005) 4.31

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes (2007) 2.75

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab (2004) 2.59

Protein adducts generated from products of lipid oxidation: focus on HNE and one. Drug Metab Rev (2006) 2.46

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J (2003) 2.43

Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem (2008) 2.09

TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04

Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res (2004) 1.95

Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry (1998) 1.92

Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. Mol Cell Proteomics (2007) 1.84

Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. Biochem J (1998) 1.76

Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. Endocrinology (2003) 1.63

Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J Biol Chem (2005) 1.60

C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome. Obesity (Silver Spring) (2007) 1.58

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol Aspects Med (2003) 1.57

Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry (1998) 1.52

Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry. Proteomics (2007) 1.47

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Oncogene (2001) 1.42

Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol (2004) 1.36

Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. Am J Physiol Cell Physiol (2005) 1.36

Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4. J Lipid Res (2006) 1.34

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice. Am J Physiol Endocrinol Metab (2003) 1.27

Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes (2008) 1.25

Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissue. J Lipid Res (2007) 1.19

Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells. J Cell Sci (2000) 1.18

Control of lipolysis and its relevance to development of obesity in man. Diabetes Metab Rev (1988) 1.17

Proteomic analysis of carbonylated proteins in two-dimensional gel electrophoresis using avidin-fluorescein affinity staining. Electrophoresis (2004) 1.16

Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes. Free Radic Biol Med (2005) 1.15

Qualitative determination of superoxide release at both sides of the mitochondrial inner membrane by capillary electrophoretic analysis of the oxidation products of triphenylphosphonium hydroethidine. Free Radic Biol Med (2009) 1.06

Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families. Diabetes (2000) 1.04

Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions. Am J Physiol Gastrointest Liver Physiol (2008) 0.96

Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. Biochim Biophys Acta (2007) 0.95

Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation. Arch Biochem Biophys (1999) 0.89

Superoxide released into the mitochondrial matrix. Free Radic Biol Med (2006) 0.86

Cysteines involved in the interconversion between dehydrogenase and oxidase forms of bovine xanthine oxidoreductase. J Dairy Sci (2000) 0.85

4-Hydroxynonenal as a second messenger of free radicals and growth modifying factor. Life Sci (1999) 0.85

Transfection of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells. Arch Biochem Biophys (1996) 0.85

Irreversible conversion of xanthine dehydrogenase into xanthine oxidase by a mitochondrial protease. FEBS Lett (1999) 0.80

Articles by these authors

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74

Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81

Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57

Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A (2005) 4.48

RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30

A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52

Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33

Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog (2009) 3.05

DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86

Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes (2009) 2.68

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49

A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet (2004) 2.47

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol (2007) 2.45

Endothelial cell recovery between comparator polymer-based drug-eluting stents. J Am Coll Cardiol (2008) 2.45

Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem (2004) 2.32

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem (2009) 2.28

Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol (2002) 2.26

Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol (2004) 2.25

Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940. Environ Sci Technol (2010) 2.23

Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (2007) 2.20

Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles. Arterioscler Thromb Vasc Biol (2006) 2.12

Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem (2008) 2.09

Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res (2004) 2.08

Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem (2008) 2.07

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem (2002) 2.05

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem (2006) 2.03

Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab (2010) 2.00

The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol (2008) 2.00

An MRI-based atlas and database of the developing mouse brain. Neuroimage (2010) 1.99

Methanobactin, a copper-acquisition compound from methane-oxidizing bacteria. Science (2004) 1.97

Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes (2003) 1.88

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A (2011) 1.86

Disposition of caspofungin: role of distribution in determining pharmacokinetics in plasma. Antimicrob Agents Chemother (2004) 1.86

Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. Mol Cell Proteomics (2007) 1.84

Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation. Biochemistry (2004) 1.84

Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.83

Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum (2005) 1.79

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77

Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab (2003) 1.74

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem (2006) 1.74

Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res (2007) 1.73

C5L2 is a functional receptor for acylation-stimulating protein. J Biol Chem (2005) 1.69

The effects of light on bleaching and tooth sensitivity during in-office vital bleaching: a systematic review and meta-analysis. J Dent (2012) 1.67

Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases. Atherosclerosis (2007) 1.67

Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64

The scourge of antibiotic resistance: the important role of the environment. Clin Infect Dis (2013) 1.64

IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. J Allergy Clin Immunol (2007) 1.63

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One (2008) 1.63

Stent graft-induced new entry after endovascular repair for Stanford type B aortic dissection. J Vasc Surg (2010) 1.62

Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol (2004) 1.61

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem (2006) 1.59

Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells. J Biol Chem (2005) 1.59

Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology (2006) 1.58

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58

Characterization of the Acyl-CoA synthetase activity of purified murine fatty acid transport protein 1. J Biol Chem (2003) 1.56

Anesthesia with nontracheal intubation in thoracic surgery. J Thorac Dis (2012) 1.56

Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation (2010) 1.54

AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension (2008) 1.54

Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis. Cancer Res (2005) 1.50

Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development (2002) 1.49

PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid Redox Signal (2010) 1.48

Disposition of caspofungin, a novel antifungal agent, in mice, rats, rabbits, and monkeys. Antimicrob Agents Chemother (2004) 1.48

Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry. Proteomics (2007) 1.47

Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: relationships with metabolic outcomes. Obesity (Silver Spring) (2013) 1.46

Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies. Environ Microbiol (2007) 1.46

Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage. Am J Physiol Endocrinol Metab (2011) 1.45

Doubly hybrid density functional xDH-PBE0 from a parameter-free global hybrid model PBE0. J Chem Phys (2012) 1.44

Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors. Oncogene (2002) 1.43

A potential probe set of fluorescence in situ hybridization for detection of lung cancer in bronchial brushing specimens. J Cancer Res Clin Oncol (2012) 1.43

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. OMICS (2009) 1.43

Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environ Health Perspect (2013) 1.42

A longitudinal assessment of coronary interventional program quality: a report from the American College of Cardiology-National Cardiovascular Data Registry. JACC Cardiovasc Interv (2009) 1.41

Acylation stimulating protein is higher in Inuit from Nunavik compared to a southern Quebec population. Int J Circumpolar Health (2009) 1.41

The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. J Biol Chem (2003) 1.41

Long-term outcome of hybrid surgical approach of video-assisted minithoracotomy sleeve lobectomy for non-small-cell lung cancer. Surg Endosc (2011) 1.40

Long-term outcome and cost-effectiveness of complete versus assisted video-assisted thoracic surgery for non-small cell lung cancer. J Surg Oncol (2011) 1.40

IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J Exp Med (2013) 1.39

Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J Biol Chem (2005) 1.38

Origins of phase contrast in the atomic force microscope in liquids. Proc Natl Acad Sci U S A (2009) 1.38

Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38

Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo. Evidence for a role in antioxidant biology. J Biol Chem (2002) 1.36

Interaction of the adipocyte fatty acid-binding protein with the hormone-sensitive lipase: regulation by fatty acids and phosphorylation. J Biol Chem (2007) 1.35

Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4. J Lipid Res (2006) 1.34

A new multimarker test for family-based association studies. Genet Epidemiol (2007) 1.34

Retrograde type A aortic dissection after endovascular stent graft placement for treatment of type B dissection. Circulation (2009) 1.33

Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets. Arthritis Rheum (2009) 1.32

Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Diabetes (2010) 1.32

Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J Med Chem (2009) 1.32

Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR. Appl Environ Microbiol (2004) 1.31

Power estimation of multiple SNP association test of case-control study and application. Genet Epidemiol (2004) 1.31

Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart. Endocrinology (2007) 1.31

Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet (2005) 1.30

Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem (2005) 1.29