Published in Blood on July 31, 2003
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol (2012) 2.98
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest (2007) 2.05
Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica (2009) 1.65
The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A (2006) 1.62
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow. Blood (2009) 1.57
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood (2008) 1.45
Red blood cells mediate the onset of thrombosis in the ferric chloride murine model. Blood (2013) 1.30
A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade. Biophys J (2010) 1.26
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
Integrins in Wound Healing. Adv Wound Care (New Rochelle) (2014) 0.90
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking. Blood (2016) 0.89
The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors. J Signal Transduct (2012) 0.83
Platelet IκB kinase-β deficiency increases mouse arterial neointima formation via delayed glycoprotein Ibα shedding. Arterioscler Thromb Vasc Biol (2012) 0.82
Next-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis'. J Cereb Blood Flow Metab (2012) 0.81
Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation. J Physiol (2004) 0.78
PECAM-1 functions as a negative regulator of laminin-induced platelet activation. J Thromb Haemost (2010) 0.78
A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury. Br J Pharmacol (2015) 0.77
Platelets and the complement cascade in atherosclerosis. Front Physiol (2015) 0.77
A vascular injury model using focal heat-induced activation of endothelial cells. Integr Biol (Camb) (2015) 0.76
Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice. PLoS One (2013) 0.76
A rat model of thrombosis in common carotid artery induced by implantable wireless light-emitting diode device. Biomed Res Int (2014) 0.75
Scleroderma. N Engl J Med (2009) 6.50
Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol (2007) 5.16
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
Differential roles of macrophages in diverse phases of skin repair. J Immunol (2010) 3.56
Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol (2007) 3.51
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol (2004) 2.94
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci (2006) 2.87
Rho GTPase function in tumorigenesis. Biochim Biophys Acta (2009) 2.81
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med (2002) 2.75
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med (2006) 2.54
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med (2003) 2.49
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood (2012) 2.43
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity (2011) 2.39
Cdc42-mediated tubulogenesis controls cell specification. Cell (2009) 2.35
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation (2007) 2.23
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood (2008) 2.18
FMNL2 drives actin-based protrusion and migration downstream of Cdc42. Curr Biol (2012) 2.18
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood (2010) 2.17
Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol (2012) 2.16
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood (2009) 2.15
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol (2002) 2.14
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood (2009) 2.09
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol (2008) 1.98
Critical role for stromal interaction molecule 1 in cardiac hypertrophy. Circulation (2011) 1.91
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood (2011) 1.88
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal (2012) 1.86
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity (2003) 1.84
G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med (2003) 1.77
Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. Blood (2013) 1.74
Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report. Arterioscler Thromb Vasc Biol (2010) 1.74
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J Exp Med (2008) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci (2007) 1.73
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol (2007) 1.69
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol (2013) 1.68
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med (2004) 1.67
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. Mol Biol Cell (2005) 1.66
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem (2002) 1.66
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest (2006) 1.65
Deficiency of von Willebrand factor protects mice from ischemic stroke. Blood (2009) 1.65
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood (2012) 1.64
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood (2012) 1.64
Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol (2003) 1.63
Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol Cell Proteomics (2012) 1.62
Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry (2002) 1.62
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol (2006) 1.58
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Blood (2010) 1.56
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse. Proc Natl Acad Sci U S A (2009) 1.55
In vivo thrombus formation in murine models. Circ Res (2007) 1.54
New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep (2007) 1.54
Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization. J Invest Dermatol (2006) 1.54
STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal (2009) 1.54
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood (2013) 1.52
Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol (2006) 1.51
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood (2003) 1.49
Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal (2010) 1.49
Rac1 regulates neuronal polarization through the WAVE complex. J Neurosci (2010) 1.49
Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis (2004) 1.48
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol (2011) 1.48
Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis (2009) 1.45
Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood (2008) 1.44
Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol (2006) 1.43
Interrelation of immunity and tissue repair or regeneration. Semin Cell Dev Biol (2009) 1.42
A2b adenosine receptors in cardioprotection: timing is everything. J Mol Cell Cardiol (2010) 1.41
Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood (2008) 1.40
Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. J Exp Med (2003) 1.39
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell (2011) 1.39
Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol (2004) 1.39
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci (2007) 1.39
Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype. Development (2006) 1.37
Mast cell-specific Cre/loxP-mediated recombination in vivo. Transgenic Res (2007) 1.36
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
Keloids--clinical diagnosis, pathogenesis, and treatment options. J Dtsch Dermatol Ges (2004) 1.34
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction. FASEB J (2012) 1.31
von Willebrand factor promotes leukocyte extravasation. Blood (2010) 1.31
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J Clin Invest (2012) 1.31
p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep (2013) 1.30