Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMID 12958031)

Published in Am J Physiol Heart Circ Physiol on September 04, 2003

Authors

Olaf Oldenburg1, Qining Qin, Thomas Krieg, Xi-Ming Yang, Sebastian Philipp, Stuart D Critz, Michael V Cohen, James M Downey

Author Affiliations

1: Dept. of Physiology, MSB 3074, Univ. of South Alabama, College of Medicine, Mobile, AL 36688, USA.

Articles citing this

Signaling pathways in ischemic preconditioning. Heart Fail Rev (2007) 2.26

Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation (2008) 2.09

Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation (2009) 1.86

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc Res (2007) 1.69

Protein S-nitrosylation and cardioprotection. Circ Res (2010) 1.63

Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling? Free Radic Biol Med (2012) 1.61

Cyclic GMP and protein kinase-G in myocardial ischaemia-reperfusion: opportunities and obstacles for survival signaling. Br J Pharmacol (2007) 1.52

Ischemia/reperfusion injury and cardioprotective mechanisms: Role of mitochondria and reactive oxygen species. World J Cardiol (2011) 1.51

Cardioprotective signaling to mitochondria. J Mol Cell Cardiol (2008) 1.49

Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT. Am J Physiol Heart Circ Physiol (2008) 1.42

Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther (2010) 1.41

Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol (2014) 1.37

Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. J Pharmacol Exp Ther (2007) 1.16

Cardioprotective PKG-independent NO signaling at reperfusion. Am J Physiol Heart Circ Physiol (2010) 1.12

Conditioning the heart induces formation of signalosomes that interact with mitochondria to open mitoKATP channels. Am J Physiol Heart Circ Physiol (2008) 1.10

The paradigm of postconditioning to protect the heart. J Cell Mol Med (2007) 1.07

Cardioprotective actions of peptide hormones in myocardial ischemia. Heart Fail Rev (2007) 1.02

Regulation of cardiac excitation and contraction by p21 activated kinase-1. Prog Biophys Mol Biol (2009) 0.99

Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore. Eur J Pharmacol (2008) 0.96

Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C. Am J Physiol Heart Circ Physiol (2008) 0.96

Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Peptides (2007) 0.96

Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. Hum Gene Ther (2008) 0.96

Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection. J Am Coll Cardiol (2012) 0.95

Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury. Med Sci Monit (2011) 0.93

Mitochondrial reactive oxygen species: which ROS signals cardioprotection? Am J Physiol Heart Circ Physiol (2013) 0.93

Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade. PLoS One (2011) 0.93

Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase. Pflugers Arch (2008) 0.92

Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways. J Mol Cell Cardiol (2007) 0.90

Signalling pathways and mechanisms of protection in pre- and postconditioning: historical perspective and lessons for the future. Br J Pharmacol (2014) 0.90

Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Br J Pharmacol (2008) 0.89

Mitochondrial therapeutics for cardioprotection. Curr Pharm Des (2011) 0.89

Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. Am J Physiol Heart Circ Physiol (2010) 0.88

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. PLoS One (2014) 0.88

Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. Cardiovasc Res (2009) 0.88

Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning. Basic Res Cardiol (2008) 0.87

Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure. Congest Heart Fail (2011) 0.87

Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning. Adv Drug Deliv Rev (2009) 0.85

Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction. Am J Physiol Cell Physiol (2010) 0.84

The "Goldilocks Zone" from a redox perspective-Adaptive vs. deleterious responses to oxidative stress in striated muscle. Front Physiol (2014) 0.84

Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling. J Am Heart Assoc (2013) 0.84

Molecular profiling reveals diversity of stress signal transduction cascades in highly penetrant Alzheimer's disease human skin fibroblasts. PLoS One (2009) 0.83

The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning. Basic Res Cardiol (2011) 0.82

A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin. Br J Pharmacol (2011) 0.82

Redox signalling and cardioprotection: translatability and mechanism. Br J Pharmacol (2015) 0.81

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS). Front Physiol (2013) 0.81

Role of endogenous vitamin E in renal ischemic preconditioning process: differences between male and female rats. Iran Biomed J (2012) 0.81

Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. FASEB J (2010) 0.80

Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice. Am J Physiol Heart Circ Physiol (2013) 0.80

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation. Sci Rep (2015) 0.79

Mechanism of Mitochondrial Connexin43's Protection of the Neurovascular Unit under Acute Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci (2016) 0.78

Effect of bradykinin on nitric oxide production, urea synthesis and viability of rat hepatocyte cultures. BMC Physiol (2005) 0.77

Efficacy of preconditioning should be gauged by reduction of infarction. Br J Pharmacol (2004) 0.77

Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications. Front Endocrinol (Lausanne) (2015) 0.76

Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress. Front Cell Neurosci (2014) 0.76

Sildenafil Protects against Myocardial Ischemia-Reperfusion Injury Following Cardiac Arrest in a Porcine Model: Possible Role of the Renin-Angiotensin System. Int J Mol Sci (2015) 0.75

Electroacupuncture prevents endothelial dysfunction induced by ischemia-reperfusion injury via a cyclooxygenase-2-dependent mechanism: A randomized controlled crossover trial. PLoS One (2017) 0.75

Protein Kinase G facilitates EGFR-mediated cell death in MDA-MB-468 cells. Exp Cell Res (2016) 0.75

The reduced myofilament responsiveness to calcium contributes to the negative force-frequency relationship in rat cardiomyocytes: role of reactive oxygen species and p-38 map kinase. Pflugers Arch (2017) 0.75

Articles by these authors

Scleroderma. N Engl J Med (2009) 6.50

Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol (2007) 5.16

Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev (2003) 3.83

Differential roles of macrophages in diverse phases of skin repair. J Immunol (2010) 3.56

Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol (2007) 3.51

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10

Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol (2004) 2.94

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood (2012) 2.43

Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res (2006) 2.39

Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity (2011) 2.39

Signaling pathways in ischemic preconditioning. Heart Fail Rev (2007) 2.26

Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res (2005) 1.86

Total liquid ventilation provides ultra-fast cardioprotective cooling. J Am Coll Cardiol (2007) 1.73

Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem (2002) 1.66

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest (2006) 1.65

Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT). Circulation (2002) 1.64

Revival of an old method with new techniques: balloon aortic valvuloplasty of the calcified aortic stenosis in the elderly. Clin Res Cardiol (2008) 1.62

The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis. Circulation (2007) 1.61

Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. Am J Physiol Heart Circ Physiol (2005) 1.59

Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion. J Mol Cell Cardiol (2007) 1.58

New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep (2007) 1.54

Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization. J Invest Dermatol (2006) 1.54

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol (2006) 1.51

Two classes of anti-platelet drugs reduce anatomical infarct size in monkey hearts. Cardiovasc Drugs Ther (2013) 1.51

Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis (2004) 1.48

Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis (2009) 1.45

Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol (2006) 1.43

Dose-response relationships of the protective and antiprotective effects of acute ethanol exposure in isolated rabbit hearts. Heart Dis (2002) 1.42

Interrelation of immunity and tissue repair or regeneration. Semin Cell Dev Biol (2009) 1.42

Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther (2010) 1.41

A2b adenosine receptors in cardioprotection: timing is everything. J Mol Cell Cardiol (2010) 1.41

Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation. Basic Res Cardiol (2004) 1.41

Why do we still not have cardioprotective drugs? Circ J (2009) 1.40

Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol (2004) 1.39

Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci (2007) 1.39

Adenosine: trigger and mediator of cardioprotection. Basic Res Cardiol (2007) 1.38

Bypassing big pharma. Circulation (2007) 1.38

Mast cell-specific Cre/loxP-mediated recombination in vivo. Transgenic Res (2007) 1.36

Keloids--clinical diagnosis, pathogenesis, and treatment options. J Dtsch Dermatol Ges (2004) 1.34

Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies. Cardiovasc Res (2005) 1.33

Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo. Blood (2003) 1.32

NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J Mol Cell Cardiol (2004) 1.29

Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J Investig Dermatol Symp Proc (2006) 1.26

cGMP signalling in pre- and post-conditioning: the role of mitochondria. Cardiovasc Res (2007) 1.25

Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas. Int J Cancer (2002) 1.23

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum Mol Genet (2006) 1.22

Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. EMBO J (2005) 1.22

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G. Basic Res Cardiol (2013) 1.21

Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci (2010) 1.21

Mitochondrial K(ATP) channels: role in cardioprotection. Cardiovasc Res (2002) 1.17

Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin. J Cell Sci (2006) 1.17

Home telemonitoring in patients with chronic heart failure: a chance to improve patient care? Dtsch Arztebl Int (2010) 1.17

Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. FASEB J (2004) 1.16

XIAP expression is an independent prognostic marker in clear-cell renal carcinomas. Hum Pathol (2004) 1.16

Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes. Thromb Haemost (2004) 1.15

Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning's success. Basic Res Cardiol (2008) 1.14

Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med (2005) 1.14

Phosphodiesterase type 5 inhibition is a novel therapeutic option in Raynaud disease. Arch Intern Med (2006) 1.14

Silicone granuloma of the face treated with minocycline. J Am Acad Dermatol (2005) 1.12

Cardioprotective PKG-independent NO signaling at reperfusion. Am J Physiol Heart Circ Physiol (2010) 1.12

p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Exp Hematol (2003) 1.11

Cell-matrix interactions in dermal repair and scarring. Fibrogenesis Tissue Repair (2010) 1.11

Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds. J Proteome Res (2010) 1.10

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice. Eur J Heart Fail (2008) 1.10

Accelerated wound closure in mice deficient for interleukin-10. Am J Pathol (2007) 1.09

Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions. Basic Res Cardiol (2008) 1.09

Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair. Am J Pathol (2006) 1.09

Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features. Arthritis Res Ther (2011) 1.09

Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1. FEBS J (2005) 1.08