Published in J Immunol on August 15, 2003
The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One (2010) 3.30
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med (2007) 2.71
Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells (2007) 2.08
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology (2004) 1.65
Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol (2006) 1.47
Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo. J Virol (2006) 1.35
Exposure-dependent effects of ethanol on the innate immune system. Alcohol (2008) 1.32
New concepts on the immune modulation mediated by mesenchymal stem cells. Stem Cell Res Ther (2010) 1.24
Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am J Pathol (2006) 1.08
Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Respir Res (2005) 1.07
Role of Toll-like receptors in health and diseases of gastrointestinal tract. World J Gastroenterol (2006) 1.06
Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages. Hum Immunol (2007) 1.03
A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model. Innate Immun (2008) 0.99
Pneumococcal pneumonia: mechanisms of infection and resolution. Chest (2012) 0.97
Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease. Clin Exp Immunol (2009) 0.96
Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes. J Leukoc Biol (2011) 0.95
Mouse models for human otitis media. Brain Res (2009) 0.92
Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4. Immunology (2005) 0.92
The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiol Aging (2007) 0.92
Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors. Mediators Inflamm (2004) 0.91
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature. Immunology (2009) 0.89
A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains. J Immunol (2008) 0.88
Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation. MBio (2014) 0.86
Pathological networking: a new approach to understanding COPD. Thorax (2007) 0.85
TRAF5 negatively regulates TLR signaling in B lymphocytes. J Immunol (2013) 0.83
Gene silencing and overexpression of porcine peptidoglycan recognition protein long isoforms: involvement in beta-defensin-1 expression. Infect Immun (2005) 0.83
Increased expression of pattern recognition receptors and nitric oxide synthase in patients with endometriosis. Int J Med Sci (2013) 0.82
Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE). Mol Immunol (2012) 0.81
Functional cell permeable motifs within medically relevant proteins. J Biotechnol (2007) 0.81
SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Front Immunol (2015) 0.81
Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset. Biomed Res Int (2014) 0.80
The Autoimmune Ecology. Front Immunol (2016) 0.77
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell. PLoS One (2015) 0.76
Orostachys japonicus Inhibits Expression of the TLR4, NOD2, iNOS, and COX-2 Genes in LPS-Stimulated Human PMA-Differentiated THP-1 Cells by Inhibiting NF-κB and MAPK Activation. Evid Based Complement Alternat Med (2015) 0.76
TLR2 expression in relation to IL-6 and IL-1beta and their natural regulators production by PMN and PBMC in patients with Lyme disease. Mediators Inflamm (2006) 0.76
Herpesviral infection and Toll-like receptor 2. Protein Cell (2012) 0.76
High toll-like receptor (TLR) 9 expression is associated with better prognosis in surgically treated pancreatic cancer patients. Virchows Arch (2017) 0.76
Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood. Thromb J (2007) 0.75
Nucleotide Sequencing and SNP Detection of Toll-Like Receptor-4 Gene in Murrah Buffalo (Bubalus bubalis). ISRN Mol Biol (2012) 0.75
Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition. Cent Eur J Immunol (2015) 0.75
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol (2010) 7.47
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol (2002) 4.63
A transgenic zebrafish model of neutrophilic inflammation. Blood (2006) 3.93
The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One (2010) 3.30
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem (2004) 2.91
Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect (2002) 2.90
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol (2005) 2.85
Immunogenicity and safety of a two-dose schedule of whole-virion and AS03A-adjuvanted 2009 influenza A (H1N1) vaccines: a randomised, multicentre, age-stratified, head-to-head trial. Lancet Infect Dis (2010) 2.67
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J Immunol (2002) 2.24
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med (2007) 2.23
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J Immunol (2003) 2.18
Immunologic consequences of Francisella tularensis live vaccine strain infection: role of the innate immune response in infection and immunity. J Immunol (2006) 2.16
Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol (2002) 2.11
Moxifloxacin monotherapy is effective in hospitalized patients with community-acquired pneumonia: the MOTIV study--a randomized clinical trial. Clin Infect Dis (2008) 2.09
Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish. J Leukoc Biol (2010) 2.08
Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. J Immunol (2008) 2.06
Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. J Infect Dis (2006) 1.99
TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol (2011) 1.98
Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology (2008) 1.98
Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. Infect Immun (2007) 1.98
Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol (2003) 1.96
Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun (2006) 1.93
Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells. J Cereb Blood Flow Metab (2003) 1.93
Severity of meningococcal disease associated with genomic bacterial load. Clin Infect Dis (2009) 1.92
Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. Thorax (2011) 1.91
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol (2003) 1.88
Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol (2006) 1.88
TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol (2009) 1.87
Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J Endotoxin Res (2006) 1.86
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol (2013) 1.85
Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J Exp Med (2003) 1.83
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol (2003) 1.80
Pneumococcal disease in HIV-infected Malawian adults: acute mortality and long-term survival. AIDS (2002) 1.79
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance. J Biol Chem (2007) 1.78
The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature (2013) 1.78
Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice. Respir Med (2004) 1.76
Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum (2008) 1.73
Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management. J Infect (2010) 1.73
Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide. J Biol Chem (2006) 1.70
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A (2009) 1.67
Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways. J Immunol (2008) 1.64
Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol (2002) 1.64
Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol (2007) 1.61
Pneumolysin: a double-edged sword during the host-pathogen interaction. Curr Mol Med (2008) 1.61
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge. Proc Natl Acad Sci U S A (2009) 1.61
Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine (2011) 1.58
The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease. Vaccine (2006) 1.57
TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem (2008) 1.55
Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists. J Immunol (2007) 1.53
Flavohemoglobin Hmp protects Salmonella enterica serovar typhimurium from nitric oxide-related killing by human macrophages. Infect Immun (2002) 1.53
Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. J Immunol (2006) 1.51
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease. Clin Infect Dis (2006) 1.51
Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cells. Infect Immun (2003) 1.49
Nitric oxide metabolism in Neisseria meningitidis. J Bacteriol (2002) 1.49
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages. J Immunol (2002) 1.47
The proteasome: a central regulator of inflammation and macrophage function. Immunol Res (2005) 1.45
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. Eur Respir J (2012) 1.44
Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages. J Biol Chem (2003) 1.44
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J Immunol (2005) 1.44
Management of meningitis. Clin Med (2005) 1.43
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J Clin Invest (2005) 1.42
Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation. J Bacteriol (2006) 1.42
Pivotal advance: activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163. J Leukoc Biol (2006) 1.40
Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. Thorax (2012) 1.40
The role of the macrophage in lung disease mediated by bacteria. Exp Lung Res (2007) 1.38
Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J Biol Chem (2008) 1.38
Acceleration of human neutrophil apoptosis by TRAIL. J Immunol (2003) 1.38
Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa. Infect Immun (2005) 1.37
Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. Sci Signal (2008) 1.37
Strategies to increase influenza vaccination rates: outcomes of a nationwide cross-sectional survey of UK general practice. BMJ Open (2012) 1.37
The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events. J Immunol (2003) 1.35
Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis. Innate Immun (2008) 1.34
TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG. J Leukoc Biol (2003) 1.33
Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. Am J Respir Crit Care Med (2008) 1.33
5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential. J Biol Chem (2012) 1.33
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J (2004) 1.33
Interaction of the Salmonella typhimurium transcription and virulence factor SlyA with target DNA and identification of members of the SlyA regulon. J Biol Chem (2002) 1.32
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol (2012) 1.31
The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis (2005) 1.30