Published in Cell Calcium on August 11, 2003
Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat Rev Neurol (2011) 2.73
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. J Neurosci (2009) 1.87
Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health (2009) 1.74
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience (2011) 1.62
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.54
The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain. Neurosci Lett (2015) 1.51
Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacol Rev (2008) 1.46
Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev (2011) 1.39
Sulfonylurea receptor 1 in central nervous system injury: a focused review. J Cereb Blood Flow Metab (2012) 1.39
Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A (2009) 1.28
Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss. J Neurosci (2006) 1.26
Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.26
N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Curr Alzheimer Res (2012) 1.20
TRPMs and neuronal cell death. Pflugers Arch (2005) 1.19
The human adult subtype ACh receptor channel has high Ca2+ permeability and predisposes to endplate Ca2+ overloading. J Physiol (2006) 1.16
The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. J Biol Chem (2010) 1.14
Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line. Hear Res (2009) 1.13
Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis. J Neurosci (2009) 1.13
Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci (2013) 1.11
Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem (2007) 1.09
Mechanisms and prospects of ischemic tolerance induced by cerebral preconditioning. Int Neurourol J (2010) 1.07
Ca2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci (2005) 1.07
Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction. Ann N Y Acad Sci (2008) 1.06
Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neurosci Lett (2007) 1.04
CaMKII in cerebral ischemia. Acta Pharmacol Sin (2011) 1.04
Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca(2+) increase. Exp Brain Res (2005) 1.02
Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases. Front Neurol (2013) 1.02
Oxidative stress and epilepsy: literature review. Oxid Med Cell Longev (2012) 0.98
TRPC channels and their implication in neurological diseases. CNS Neurol Disord Drug Targets (2010) 0.97
Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function. Exp Neurol (2009) 0.97
Socially responsive effects of brain oxidative metabolism on aggression. Proc Natl Acad Sci U S A (2014) 0.97
Killer proteases and little strokes--how the things that do not kill you make you stronger. J Cereb Blood Flow Metab (2006) 0.96
Specificity in S-nitrosylation: a short-range mechanism for NO signaling? Antioxid Redox Signal (2013) 0.96
Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model. Hum Mol Genet (2012) 0.95
Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture. Toxicol Sci (2012) 0.93
Localized loss of Ca2+ homeostasis in neuronal dendrites is a downstream consequence of metabolic compromise during extended NMDA exposures. J Neurosci (2008) 0.92
The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. Invest Ophthalmol Vis Sci (2011) 0.91
Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Exp Neurol (2012) 0.91
Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model. ASN Neuro (2012) 0.91
Intracellular Zn2+ increases contribute to the progression of excitotoxic Ca2+ increases in apical dendrites of CA1 pyramidal neurons. Neuroscience (2008) 0.90
Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicol Appl Pharmacol (2009) 0.90
Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytes. Acta Pharmacol Sin (2008) 0.89
Control of intracellular calcium signaling as a neuroprotective strategy. Molecules (2010) 0.89
Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis. Mol Neurodegener (2009) 0.89
Neuroprotection in glaucoma. Indian J Ophthalmol (2011) 0.88
Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK, and PI3K/AKT signaling pathways. Cell Mol Neurobiol (2012) 0.88
Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability. Mol Cell Neurosci (2007) 0.88
Inhibition of a SNARE-sensitive pathway in astrocytes attenuates damage following stroke. J Neurosci (2013) 0.87
The role of trace elements in the pathogenesis and progress of pilocarpine-induced epileptic seizures. J Biol Inorg Chem (2008) 0.87
Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons. J Physiol (2012) 0.86
In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation. PLoS One (2012) 0.86
Protein kinase C-regulated aβ production and clearance. Int J Alzheimers Dis (2011) 0.86
Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience (2011) 0.86
The ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors. Curr Opin Investig Drugs (2005) 0.86
NFAT5-dependent expression of AQP4 in astrocytes. Cell Mol Neurobiol (2012) 0.85
Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons. PLoS One (2012) 0.85
N-PEP-12--a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions. J Neural Transm (Vienna) (2005) 0.85
Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT. Neurobiol Dis (2014) 0.84
Emergence of a spermine-sensitive, non-inactivating conductance in mature hippocampal CA1 pyramidal neurons upon reduction of extracellular Ca2+: dependence on intracellular Mg2+ and ATP. Neurochem Int (2006) 0.84
Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats. Surg Today (2010) 0.84
Mitochondrial Ca2+ homeostasis in lysosomal storage diseases. Cell Calcium (2008) 0.84
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury. PLoS One (2013) 0.84
Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation. Exp Neurol (2011) 0.83
Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells. Cell Death Differ (2010) 0.83
Bile components and amino acids affect survival of the newly excysted juvenile Clonorchis sinensis in maintaining media. Parasitol Res (2008) 0.83
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. EMBO J (2014) 0.83
Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle. J Physiol (2007) 0.83
Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current. PLoS One (2012) 0.83
Therapeutic potential of kainate receptors. CNS Neurosci Ther (2010) 0.83
Ex vivo imaging of active caspase 3 by a FRET-based molecular probe demonstrates the cellular dynamics and localization of the protease in cerebellar granule cells and its regulation by the apoptosis-inhibiting protein survivin. Mol Neurodegener (2016) 0.82
Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. J Cell Biol (2008) 0.82
Type 2 transglutaminase in Huntington's disease: a double-edged sword with clinical potential. J Intern Med (2010) 0.82
HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment. Am J Pathol (2010) 0.82
Activity-dependent survival of neurons in culture: a model of slow neurodegeneration. J Neural Transm (Vienna) (2009) 0.82
Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity. Front Neurol (2012) 0.82
ASTROCYTES: EMERGING STARS IN LEUKODYSTROPHY PATHOGENESIS. Transl Neurosci (2013) 0.82
Glibenclamide in cerebral ischemia and stroke. Neurocrit Care (2014) 0.82
Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases. Cell Mol Neurobiol (2013) 0.82
Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicity. J Physiol (2010) 0.81
Molecular genetics of retinal degeneration: A Drosophila perspective. Fly (Austin) (2011) 0.81
Variations in elemental compositions of rat hippocampal formation between acute and latent phases of pilocarpine-induced epilepsy: an X-ray fluorescence microscopy study. J Biol Inorg Chem (2012) 0.81
Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model. J Neurochem (2014) 0.81
Guanosine and its role in neuropathologies. Purinergic Signal (2016) 0.81
Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signaling cascade. Cell Mol Neurobiol (2014) 0.81
Inhibition of NR2B-Containing N-methyl-D-Aspartate Receptors (NMDARs) in Experimental Autoimmune Encephalomyelitis, a Model of Multiple Sclerosis. Iran J Pharm Res (2014) 0.80
Alleviation by Hypericum perforatum of the stress-induced impairment of spatial working memory in rats. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.80
Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression. Metab Brain Dis (2014) 0.80
Spatiotemporal expression of Dexras1 after spinal cord transection in rats. Cell Mol Neurobiol (2008) 0.79
Targeting specific cells in the brain with nanomedicines for CNS therapies. J Control Release (2015) 0.79
Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells. Int J Mol Med (2013) 0.79
A double-blind, placebo controlled, randomized trial of riluzole as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia. Psychopharmacology (Berl) (2013) 0.79
Analysis of neuroprotective effects of valproic acid on primary motor neurons in monoculture or co-cultures with astrocytes or Schwann cells. Cell Mol Neurobiol (2009) 0.79
Volume-regulated anion channel-a frenemy within the brain. Pflugers Arch (2015) 0.79
Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain. J Neural Transm (Vienna) (2011) 0.79
Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats. J Mol Histol (2012) 0.78
Trifluoperazine protects brain plasma membrane Ca(2+)-ATPase from oxidative damaging. Exp Brain Res (2007) 0.78
Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus. J Virol (2013) 0.78
NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic acid differentiated SH-SY5Y Cells. J Mol Signal (2012) 0.78
A microplate technique to simultaneously assay calcium accumulation in endoplasmic reticulum and SERCA release of inorganic phosphate. Biol Proced Online (2012) 0.78
A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46
Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature (2012) 4.04
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science (2002) 3.98
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci (2007) 3.44
Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch (2010) 2.83
Calcium, ischemia and excitotoxicity. Cell Calcium (2010) 2.38
Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2012) 2.34
Intracranial aneurysms: from vessel wall pathology to therapeutic approach. Nat Rev Neurol (2011) 1.77
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Steal physiology is spatially associated with cortical thinning. J Neurol Neurosurg Psychiatry (2010) 1.73
The natural history and predictive features of hemorrhage from brain arteriovenous malformations. Stroke (2008) 1.67
Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury. J Neurosci (2006) 1.63
PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci (2007) 1.62
Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci (2008) 1.62
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci (2008) 1.58
Impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations. Brain (2010) 1.56
Priority setting in neurosurgery as exemplified by an everyday challenge. Can J Neurol Sci (2013) 1.39
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat. Stroke (2008) 1.31
Preoperative and postoperative mapping of cerebrovascular reactivity in moyamoya disease by using blood oxygen level-dependent magnetic resonance imaging. J Neurosurg (2005) 1.23
TRPMs and neuronal cell death. Pflugers Arch (2005) 1.19
Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol (2009) 1.19
Vulnerability of central neurons to secondary insults after in vitro mechanical stretch. J Neurosci (2004) 1.15
A discriminative prediction model of neurological outcome for patients undergoing surgery of brain arteriovenous malformations. Stroke (2006) 1.12
Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Curr Mol Med (2004) 1.11
Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractography. Neurosurgery (2011) 1.10
Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci (2011) 1.09
Nonhuman primate models of stroke for translational neuroprotection research. Neurotherapeutics (2012) 1.05
Impaired cerebrovascular reactivity with steal phenomenon is associated with increased diffusion in white matter of patients with Moyamoya disease. Stroke (2010) 1.04
Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors. Biochem Pharmacol (2003) 1.02
A translational paradigm for the preclinical evaluation of the stroke neuroprotectant Tat-NR2B9c in gyrencephalic nonhuman primates. Sci Transl Med (2012) 1.02
Impact of extracranial-intracranial bypass on cerebrovascular reactivity and clinical outcome in patients with symptomatic moyamoya vasculopathy. Stroke (2011) 0.99
Cellular schwannoma of the abducens nerve: case report and review of the literature. Clin Neurol Neurosurg (2009) 0.98
Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor. Stroke (2011) 0.98
TRPM7 and ischemic CNS injury. Neuroscientist (2005) 0.95
Impact of individual intracranial arterial aneurysm morphology on initial obliteration and recurrence rates of endovascular treatments: a multivariate analysis. J Neurosurg (2010) 0.93
Surgical revascularization reverses cerebral cortical thinning in patients with severe cerebrovascular steno-occlusive disease. Stroke (2011) 0.91
Symptomatic enlargement of an occluded giant carotido-ophthalmic aneurysm after endovascular treatment: the vasa vasorum theory. Acta Neurochir (Wien) (2009) 0.90
Severely impaired cerebrovascular reserve in patients with cerebral proliferative angiopathy. J Neurosurg Pediatr (2011) 0.90
Analysis of cost related to clinical and angiographic outcomes of aneurysm patients enrolled in the international subarachnoid aneurysm trial in a North American setting. Neurosurgery (2005) 0.89
The contribution of imaging in diagnosis, preoperative assessment, and follow-up of moyamoya disease: a review. Neurosurg Focus (2009) 0.88
Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro. J Neurotrauma (2003) 0.88
Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture. Stroke (2011) 0.85
Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain (2011) 0.84
Translating promising preclinical neuroprotective therapies to human stroke trials. Expert Rev Cardiovasc Ther (2011) 0.84
Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death. J Neurosci (2013) 0.84
Intraoperative biplanar rotational angiography during neurovascular surgery. Technical note. J Neurosurg (2009) 0.82
Assessment of extracranial-intracranial bypass patency with 64-slice multidetector computerized tomography angiography. Neuroradiology (2009) 0.81
A safety, length of stay, and cost analysis of minimally invasive microsurgery for anterior circulation aneurysms. Acta Neurochir (Wien) (2014) 0.81
The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures. Methods Mol Biol (2007) 0.81
Overview of the current role of endovascular and surgical treatment in spinal dural arteriovenous fistulas. Neurosurg Focus (2009) 0.81
Multidisciplinary care of occipital arteriovenous malformations: effect on nonhemorrhagic headache, vision, and outcome in a series of 135 patients. Clinical article. J Neurosurg (2010) 0.81
Challenges in the management of ruptured and unruptured brainstem arteriovenous malformations: outcome after conservative, single-modality, or multimodality treatments. Neurosurgery (2012) 0.81
Novel concepts in excitotoxic neurodegeneration after stroke. Expert Rev Mol Med (2003) 0.79
Advances in vascular neurosurgery 2010. Stroke (2011) 0.79
Pituitary adenoma associated with intraventricular meningioma: case report. Skull Base (2007) 0.79
BOLD MRI and early impairment of cerebrovascular reserve after aneurysmal subarachnoid hemorrhage. J Magn Reson Imaging (2013) 0.77
Early identification of brain tissue at risk for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl (2015) 0.77
Impaired cerebrovascular reactivity in the early phase of subarachnoid hemorrhage in good clinical grade patients does not predict vasospasm. Acta Neurochir Suppl (2015) 0.76
Transmastoid partial labyrinthectomy for brainstem vascular lesions: clinical outcomes and assessment of postoperative cochleovestibular function. Skull Base (2006) 0.75
Microsurgical glue embolectomy of the middle cerebral artery following embolization of a maxillofacial arteriovenous malformation. J Clin Neurosci (2011) 0.75
Postoperative assessment of clipped aneurysms with 64-slice computerized tomography angiography. Neurosurgery (2010) 0.75
Advances in stroke: vascular neurosurgery. Stroke (2013) 0.75
Symptomatic non-atherosclerotic bilateral extracranial vertebral artery occlusion treated with extracranial to intracranial bypass: case report. Arq Neuropsiquiatr (2006) 0.75
805 A Single-Center, Prospective Analysis of the Natural History of Hemorrhage from Brain Arteriovenous Malformations with or without Associated Aneurysms. Neurosurgery (2005) 0.75
Day surgery craniotomy for unruptured cerebral aneurysms: a single center experience. J Neurosurg Anesthesiol (2014) 0.75
Peptide action in stroke therapy. Expert Opin Biol Ther (2003) 0.75
Neuroprotective strategies in epilepsy. Adv Exp Med Biol (2002) 0.75