Published in Int J Mol Med on January 15, 2013
A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis. J Neurodev Disord (2015) 0.87
Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Biol Open (2015) 0.83
Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure. Neural Plast (2016) 0.81
Persistent Impact of In utero Irradiation on Mouse Brain Structure and Function Characterized by MR Imaging and Behavioral Analysis. Front Behav Neurosci (2016) 0.80
Combined Exposure to Simulated Microgravity and Acute or Chronic Radiation Reduces Neuronal Network Integrity and Survival. PLoS One (2016) 0.75
Neuroligins and neurexins link synaptic function to cognitive disease. Nature (2008) 9.23
Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol (2008) 8.30
Clinical implications of the p53 tumor-suppressor gene. N Engl J Med (1993) 7.29
Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med (1994) 6.77
Cell death during development of the nervous system. Annu Rev Neurosci (1991) 6.37
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron (2008) 6.26
Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53
DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) (2004) 2.86
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell (2005) 2.63
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int (2004) 2.47
Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium (2003) 2.21
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J (1997) 1.96
Enzymatic processing of radiation-induced free radical damage in DNA. Radiat Res (1998) 1.78
Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"? J Biol Chem (2000) 1.77
Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron (1988) 1.67
Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration. J Biol Chem (2003) 1.55
Spectrin and calpain: a 'target' and a 'sniper' in the pathology of neuronal cells. Cell Mol Life Sci (2005) 1.41
Cellular radiosensitivity: how much better do we understand it? Int J Radiat Biol (2009) 1.40
NMDA Receptors in glia. Neuroscientist (2007) 1.33
ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum Mol Genet (2003) 1.28
Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients. Acta Oncol (2008) 1.24
Synaptic NMDA receptors mediate hypoxic excitotoxic death. J Neurosci (2012) 1.22
Salinomycin induces calpain and cytochrome c-mediated neuronal cell death. Cell Death Dis (2011) 1.20
Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition. Am J Physiol Heart Circ Physiol (2005) 1.17
Redox active calcium ion channels and cell death. Arch Biochem Biophys (2005) 1.13
Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses. Neurosignals (2004) 1.12
Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action. Free Radic Biol Med (2006) 1.12
Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem Biophys Res Commun (1999) 1.11
Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis. Cancer Res (1996) 1.03
Calpains mediate p53 activation and neuronal death evoked by DNA damage. J Biol Chem (2003) 1.02
Interventional radiology in pregnancy complications: indications, technique, and methods for minimizing radiation exposure. Radiographics (2012) 1.01
GSK3beta in ethanol neurotoxicity. Mol Neurobiol (2009) 1.01
Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. J Neurochem (2000) 1.00
Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors. Int J Radiat Biol (1998) 0.98
A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome. PLoS One (2010) 0.98
High content image cytometry in the context of subnuclear organization. Cytometry A (2010) 0.97
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. J Neurosci (2012) 0.97
An update on the potential role of excitotoxicity in the pathogenesis of Parkinson's disease. Funct Neurol (2010) 0.96
Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage. J Neurosci (2001) 0.94
Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Proc Natl Acad Sci U S A (2011) 0.88
Effect of radiation on the development of immature hippocampal neurons in vitro. Radiat Res (2009) 0.86
Synaptogenesis in layer I of the human cerebral cortex in the first half of gestation. Cereb Cortex (1998) 0.86
Axon & dendrite degeneration: its mechanisms and protective experimental paradigms. Neurochem Int (2007) 0.85
Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. PLoS One (2012) 0.84
p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus. Neuroreport (2000) 0.84
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke (1995) 0.83
The role of Trp53 in the transcriptional response to ionizing radiation in the developing brain. DNA Res (2006) 0.83
Quantitative assessment of central nervous system disorder induced by prenatal X-ray exposure using diffusion and manganese-enhanced MRI. NMR Biomed (2011) 0.81
p53 expression and regulation by NMDA receptors in the developing rat brain. J Neurosci Res (1999) 0.80
In utero radiation-induced apoptosis and p53 gene expression in the developing rat brain. Int J Radiat Biol (2001) 0.79
Acute effects of irradiation on the rat brain: protection by glutamate blockade. Eur J Pharmacol (1995) 0.79
Synaptogenesis in the neocortical anlage and early developing neocortex of rat embryos. Acta Anat (Basel) (1996) 0.77
Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx. J Pharmacol Sci (2009) 0.76
Standardization of real-time PCR gene expression data from independent biological replicates. Anal Biochem (2008) 2.46
The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology (2006) 2.10
State of the art in research into the risk of low dose radiation exposure--findings of the fourth MELODI workshop. J Radiol Prot (2013) 2.06
Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn (2005) 1.60
Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun (2007) 1.52
Selection of reference genes in mouse embryos and in differentiating human and mouse ES cells. Int J Dev Biol (2006) 1.50
EPI-CT: design, challenges and epidemiological methods of an international study on cancer risk after paediatric and young adult CT. J Radiol Prot (2015) 1.46
Telomere biology in mammalian germ cells and during development. Dev Biol (2004) 1.31
Non-conventional Frizzled ligands and Wnt receptors. Dev Growth Differ (2008) 1.20
Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling. Dev Dyn (2007) 1.12
Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity. Differentiation (2008) 1.07
Ionizing radiation biomarkers for potential use in epidemiological studies. Mutat Res (2012) 0.99
An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryoid bodies. Nat Protoc (2008) 0.98
Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. J Cell Biochem (2007) 0.98
Stress response and humoral immune system alterations related to chronic hypergravity in mice. Psychoneuroendocrinology (2011) 0.98
A genomic approach reveals a novel mitotic pathway in papillomavirus carcinogenesis. Cancer Res (2004) 0.96
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids. FASEB J (2012) 0.95
Different responsiveness of endothelial cells to vascular endothelial growth factor and basic fibroblast growth factor added to culture media under gravity and simulated microgravity. Tissue Eng Part A (2010) 0.95
A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Eng Part A (2009) 0.93
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. Dev Biol (2008) 0.93
A new validated mathematical model of the Wnt signalling pathway predicts effective combinational therapy by sFRP and Dkk. Biochem J (2012) 0.92
Gene set enrichment analysis highlights different gene expression profiles in whole blood samples X-irradiated with low and high doses. Int J Radiat Biol (2013) 0.92
A non-tree-based comprehensive study of metazoan Hox and ParaHox genes prompts new insights into their origin and evolution. BMC Evol Biol (2010) 0.89
Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111. Cytoskeleton (Hoboken) (2011) 0.89
How and why does the proteome respond to microgravity? Expert Rev Proteomics (2011) 0.89
Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation. Int J Radiat Biol (2014) 0.88
Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes. Int J Mol Med (2013) 0.88
Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity. J Cell Biochem (2008) 0.87
HoxPred: automated classification of Hox proteins using combinations of generalised profiles. BMC Bioinformatics (2007) 0.87
Development of 177Lu-nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators. Contrast Media Mol Imaging (2012) 0.86
Anterior-posterior patterning of neural differentiated embryonic stem cells by canonical Wnts, Fgfs, Bmp4 and their respective antagonists. Dev Growth Differ (2009) 0.85
The response of Cupriavidus metallidurans CH34 to spaceflight in the international space station. Antonie Van Leeuwenhoek (2009) 0.84
Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation. Int J Dev Biol (2005) 0.84
Simulated microgravity decreases apoptosis in fetal fibroblasts. Int J Mol Med (2012) 0.83
A PCR survey for posterior Hox genes in amphibians. Mol Phylogenet Evol (2005) 0.83
Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain. Brain Res Rev (2006) 0.82
Comparison of different protocols for telomere length estimation by combination of quantitative fluorescence in situ hybridization (Q-FISH) and flow cytometry in human cancer cell lines. Anticancer Res (2005) 0.82
Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells. Mutat Res (2011) 0.81
Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. FASEB J (2012) 0.80
Concerted Uranium Research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure. J Radiol Prot (2016) 0.80
Influence of serum on in situ proliferation and genotoxicity in A549 human lung cells exposed to nanomaterials. Mutat Res (2011) 0.79
Morphological and physiological changes in mature in vitro neuronal networks towards exposure to short-, middle- or long-term simulated microgravity. PLoS One (2013) 0.79
Differential response to acute low dose radiation in primary and immortalized endothelial cells. Int J Radiat Biol (2013) 0.79
Medium-mediated DNA repair response after ionizing radiation is correlated with the increase of specific cytokines in human fibroblasts. Mutat Res (2010) 0.79
Postoperative 5-FU based radiochemotherapy in rectal cancer: retrospective long term results and prognostic factors of a pooled analysis on 1,338 patients. Anticancer Res (2013) 0.79
Apoptosis: a mechanism of cell suicide. In Vivo (2003) 0.78
Multiplexed profiling of secreted proteins for the detection of potential space biomarkers. Mol Med Rep (2010) 0.78
Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes. Nanotoxicology (2014) 0.78
MorphoNeuroNet: an automated method for dense neurite network analysis. Cytometry A (2013) 0.77
High content analysis of human fibroblast cell cultures after exposure to space radiation. Radiat Res (2009) 0.77
Radiation-induced double strand breaks and subsequent apoptotic DNA fragmentation in human peripheral blood mononuclear cells. Int J Mol Med (2012) 0.77
Adjuvant chemoradiotherapy in gastric cancer: a pooled analysis of the AIRO gastrointestinal group experience. Tumori (2015) 0.76
Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development. DNA Repair (Amst) (2005) 0.76
Repeated exposure of human fibroblasts to ionizing radiation reveals an adaptive response that is not mediated by interleukin-6 or TGF-β. Mutat Res (2011) 0.76
Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight. PLoS One (2013) 0.75
Reply to 'State of the art in research into the risk of low dose radiation exposure'. J Radiol Prot (2014) 0.75
Whole-mount in situ hybridization (WISH) optimized for gene expression analysis in mouse embryos and embryoid bodies. Methods Mol Biol (2014) 0.75
Amorphous silica nanoparticles alter microtubule dynamics and cell migration. Nanotoxicology (2014) 0.75
The role of brachytherapy in the management of oropharyngeal carcinomas: the Trento experience. Tumori (2002) 0.75
Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. Int J Oncol (2011) 0.75
Early adaption to the antarctic environment at dome C: consequences on stress-sensitive innate immune functions. High Alt Med Biol (2014) 0.75
X-irradiation induces cell death in fetal fibroblasts. Int J Mol Med (2012) 0.75