Published in Development on August 13, 2003
Early steps in the development of the forebrain. Dev Cell (2004) 2.34
Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci (2009) 2.03
Efficient derivation of functional floor plate tissue from human embryonic stem cells. Cell Stem Cell (2010) 2.02
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev (2010) 1.51
Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Development (2004) 0.98
Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells (2012) 0.93
Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling. Dev Dyn (2008) 0.84
Medial floor plate formation in zebrafish consists of two phases and requires trunk-derived Midkine-a. Genes Dev (2005) 0.83
A novel role for FOXA2 and SHH in organizing midbrain signaling centers. Dev Biol (2012) 0.82
A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling. Dev Biol (2011) 0.81
Patterns of hypothalamic regionalization in amphibians and reptiles: common traits revealed by a genoarchitectonic approach. Front Neuroanat (2015) 0.80
Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord. Development (2010) 0.80
Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation. Development (2017) 0.76
Optochemical dissection of T-box gene-dependent medial floor plate development. ACS Chem Biol (2015) 0.76
ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm. Development (2015) 0.75
FoxA4 favours notochord formation by inhibiting contiguous mesodermal fates and restricts anterior neural development in Xenopus embryos. PLoS One (2014) 0.75
Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem (2017) 0.75
A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature (2009) 5.65
Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev (2009) 2.99
Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity. Nat Cell Biol (2013) 2.90
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A (2002) 2.89
Prostatic intraepithelial neoplasia in genetically engineered mice. Am J Pathol (2002) 2.48
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47
Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport. Proc Natl Acad Sci U S A (2004) 2.32
Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron (2004) 2.32
Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res (2002) 2.29
Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat Rev Genet (2006) 2.26
SOX genes and neural progenitor identity. Curr Opin Neurobiol (2005) 2.18
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res (2003) 2.11
A robust system for RNA interference in the chicken using a modified microRNA operon. Dev Biol (2006) 1.83
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol (2002) 1.80
Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2006) 1.78
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development (2003) 1.73
Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res (2006) 1.62
A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration. J Neurosci (2004) 1.56
Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Differentiation (2008) 1.55
Mouse models of prostate carcinogenesis. Trends Genet (2002) 1.52
Two modes by which Lefty proteins inhibit nodal signaling. Curr Biol (2004) 1.51
Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol (2004) 1.50
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A (2004) 1.47
Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer. Cancer Res (2008) 1.42
Sox9 is required for prostate development. Dev Biol (2008) 1.40
The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development (2006) 1.40
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development (2007) 1.38
Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res (2008) 1.36
A molecular signature predictive of indolent prostate cancer. Sci Transl Med (2013) 1.32
The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature (2008) 1.31
Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration. Prostate (2009) 1.30
ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc Natl Acad Sci U S A (2013) 1.26
Authors' response: generic medications in ophthalmology. Br J Ophthalmol (2013) 1.21
Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res (2012) 1.20
Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development (2007) 1.19
Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation. Dev Cell (2006) 1.18
Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development (2002) 1.18
Logarithmic intensity and speckle-based motion contrast methods for human retinal vasculature visualization using swept source optical coherence tomography. Biomed Opt Express (2012) 1.16
Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development (2006) 1.15
B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Res (2012) 1.15
Opponent activities of Shh and BMP signaling during floor plate induction in vivo. Curr Biol (2002) 1.15
Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis. Development (2008) 1.13
Directed differentiation of neural cells to hypothalamic dopaminergic neurons. Development (2005) 1.13
Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci (2005) 1.12
The trophic role of oligodendrocytes in the basal forebrain. J Neurosci (2003) 1.12
Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development (2005) 1.10
Diagnostics: The prostate-cancer metabolome. Nature (2009) 1.09
Ocular developmental abnormalities and glaucoma associated with interstitial 6p25 duplications and deletions. Invest Ophthalmol Vis Sci (2002) 1.05
FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools. Development (2011) 1.03
Which quality of life score is best for glaucoma patients and why? BMC Ophthalmol (2008) 1.01
Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science (2002) 0.99
A novel homeobox mutation in the PITX2 gene in a family with Axenfeld-Rieger syndrome associated with brain, ocular, and dental phenotypes. Am J Med Genet B Neuropsychiatr Genet (2006) 0.99
Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci (2010) 0.97
Temporal progression of hypothalamic patterning by a dual action of BMP. Development (2008) 0.97
Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem (2009) 0.96
The roots of cancer: stem cells and the basis for tumor heterogeneity. Bioessays (2012) 0.96
Secondary pigment dispersion syndrome with single-piece acrylic IOL. J Cataract Refract Surg (2010) 0.93
Cytoskeletal polarity mediates localized induction of the heart progenitor lineage. Nat Cell Biol (2011) 0.93
FGF signaling in prostate tumorigenesis--new insights into epithelial-stromal interactions. Cancer Cell (2007) 0.89
Two nodal-responsive enhancers control left-right asymmetric expression of Nodal. Dev Dyn (2005) 0.88
Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. Dev Biol (2010) 0.88
Development of the medial hypothalamus: forming a functional hypothalamic-neurohypophyseal interface. Curr Top Dev Biol (2013) 0.88
Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase. Mol Membr Biol (2011) 0.86
Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling. Development (2011) 0.86
Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis. Dev Dyn (2013) 0.85
Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. Proc Natl Acad Sci U S A (2012) 0.85
Effects of Multi-modal Physiotherapy, Including Hip Abductor Strengthening, in Patients with Iliotibial Band Friction Syndrome. Physiother Can (2008) 0.84
Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging (2003) 0.84
Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression. Dis Model Mech (2012) 0.84
FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development. Development (2011) 0.83
Genetic risk for primary open-angle glaucoma determined by LMX1B haplotypes. Invest Ophthalmol Vis Sci (2008) 0.83
Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase. Mol Membr Biol (2010) 0.82
Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase. Biochem Biophys Res Commun (2011) 0.82
Comparison of a physiotherapy program versus dexamethasone injections for plantar fasciopathy in prolonged standing workers: a randomized clinical trial. Clin J Sport Med (2014) 0.81
Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Dev Dyn (2008) 0.80
Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2. Prostate (2012) 0.80
Time-lapse imaging of the early avian embryo. Methods Cell Biol (2008) 0.80
Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma. Clin Ophthalmol (2009) 0.79
Trajectory approach to two-state kinetics of single particles on sculpted energy landscapes. Phys Rev Lett (2009) 0.79
Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis. Development (2013) 0.79
Modeling a hox gene network in silico using a stochastic simulation algorithm. Dev Biol (2002) 0.79
Development and characterization of a novel CD19CherryLuciferase (CD19CL) transgenic mouse for the preclinical study of B-cell lymphomas. Clin Cancer Res (2012) 0.79
SnapShot: Prostate cancer. Cancer Cell (2013) 0.78
Examining the degree of pain reduction using a multielement exercise model with a conventional training shoe versus an ultraflexible training shoe for treating plantar fasciitis. Phys Sportsmed (2009) 0.78
Retinal detachment. BMJ Clin Evid (2008) 0.78
Axon guidance effect of classical morphogens Shh and BMP7 in the hypothalamo-pituitary system. Neurosci Lett (2013) 0.77
Down-regulation of Na+-coupled glutamate transporter EAAT3 and EAAT4 by AMP-activated protein kinase. J Neurochem (2010) 0.77
Inhibition of connexin 26 by the AMP-activated protein kinase. J Membr Biol (2011) 0.77
What's in a name? Medication terms: what they mean and when to use them. Br J Ophthalmol (2007) 0.77
An unusual gene dosage effect of p27kip1 in a mouse model of prostate cancer. Cell Cycle (2005) 0.76
Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells. BMC Neurosci (2013) 0.75
Scott Fraser: live action embryology. Interview by R Williams. J Cell Biol (2007) 0.75
Common TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma. Mol Vis (2012) 0.75
Viscogonioplasty in narrow angle glaucoma: a randomized controlled trial. Clin Ophthalmol (2010) 0.75
Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks. Cell (2016) 0.75
Static culture of postimplantation embryos for imaging. CSH Protoc (2006) 0.75
Axon guidance effects of classical morphogens Shh and BMP7 in the hypothalamo-pituitary system. Neurosci Lett (2014) 0.75