Published in Development on December 01, 2003
Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol (2014) 10.04
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A (2008) 2.99
Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell (2008) 2.64
Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol (2006) 2.63
Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42
Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev (2011) 2.22
Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A (2009) 1.86
The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol (2007) 1.52
Canonical Wnt/β-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells (2010) 1.43
Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo. Development (2011) 1.33
Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin. Proc Natl Acad Sci U S A (2008) 1.32
Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications. Hum Reprod Update (2010) 1.28
Phenotypic annotation of the mouse X chromosome. Genome Res (2010) 1.26
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer. Am J Pathol (2012) 1.20
Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. Development (2014) 1.20
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt. Pigment Cell Melanoma Res (2009) 1.19
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells (2013) 1.14
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol (2009) 1.14
Gene targeting of CK2 catalytic subunits. Mol Cell Biochem (2008) 1.12
Differentiating embryonic stem cells pass through 'temporal windows' that mark responsiveness to exogenous and paracrine mesendoderm inducing signals. PLoS One (2010) 1.12
Role of Cripto-1 in stem cell maintenance and malignant progression. Am J Pathol (2010) 1.09
Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb Perspect Biol (2012) 1.06
Epiblast ground state is controlled by canonical Wnt/β-catenin signaling in the postimplantation mouse embryo and epiblast stem cells. PLoS One (2013) 1.03
Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis. Am J Pathol (2005) 0.99
CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports (2014) 0.96
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal (2012) 0.92
Resolving early mesoderm diversification through single-cell expression profiling. Nature (2016) 0.92
Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol (2012) 0.91
Composition and regulation of maternal and zygotic transcriptomes reflects species-specific reproductive mode. Genome Biol (2010) 0.90
beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. Biochem Biophys Res Commun (2007) 0.90
Targeting the embryonic gene Cripto-1 in cancer and beyond. Expert Opin Ther Pat (2010) 0.89
Anti-Cripto Mab inhibit tumour growth and overcome MDR in a human leukaemia MDR cell line by inhibition of Akt and activation of JNK/SAPK and bad death pathways. Br J Cancer (2007) 0.89
Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. Dev Biol (2010) 0.88
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. PLoS Genet (2015) 0.88
Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development (2013) 0.88
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition. Semin Cancer Biol (2014) 0.87
Transcriptional profiling of putative human epithelial stem cells. BMC Genomics (2008) 0.87
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol (2008) 0.87
Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol (2013) 0.85
Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Dis Model Mech (2014) 0.84
Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application. Cell Mol Life Sci (2014) 0.82
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer. Breast Cancer Res Treat (2016) 0.80
Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning. PLoS One (2011) 0.80
Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells. PLoS One (2013) 0.79
Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma. BMC Cancer (2009) 0.79
The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biol (2015) 0.79
Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells. Semin Cell Dev Biol (2015) 0.79
Mouse Tenm4 is required for mesoderm induction. BMC Dev Biol (2013) 0.77
Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor-Mediated Pathway. Am J Pathol (2015) 0.77
Autoregulation and heterogeneity in expression of human Cripto-1. PLoS One (2015) 0.76
Rho kinase activity controls directional cell movements during primitive streak formation in the rabbit embryo. Development (2015) 0.75
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. Elife (2016) 0.75
MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway. PLoS One (2016) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
Met, metastasis, motility and more. Nat Rev Mol Cell Biol (2003) 14.30
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Wnt signalling and its impact on development and cancer. Nat Rev Cancer (2008) 8.37
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell (2005) 6.90
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet (2010) 6.81
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55
Targeting MET in cancer: rationale and progress. Nat Rev Cancer (2012) 6.43
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09
Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature (2009) 5.65
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29
Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res (2006) 5.23
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
The intestinal stem cell. Genes Dev (2008) 4.21
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell (2006) 4.13
Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol (2006) 3.98
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet (2004) 3.88
Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev (2005) 3.79
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem (2003) 3.37
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30