Published in Development on September 28, 2015
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol (2007) 8.08
Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell (1996) 7.70
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet (1996) 5.70
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci (2005) 4.86
Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet (1996) 4.54
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet (1996) 3.50
Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature (1998) 3.21
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature (1999) 3.19
Structural basis for FGF receptor dimerization and activation. Cell (1999) 3.19
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12
Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature (2007) 2.97
A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers. Development (2006) 2.90
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development (1998) 2.67
Nodal signalling in the epiblast patterns the early mouse embryo. Nature (2001) 2.65
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell (2001) 2.58
Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature (1993) 2.45
Inductive interactions direct early regionalization of the mouse forebrain. Development (1997) 2.43
Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell (1992) 2.34
Longitudinal organization of the anterior neural plate and neural tube. Development (1995) 2.25
Nodal signalling in vertebrate development. Nature (2000) 2.20
The zebrafish Nodal signal Squint functions as a morphogen. Nature (2001) 2.16
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell (2006) 2.13
Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development (1997) 1.91
Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev (2003) 1.91
A robust system for RNA interference in the chicken using a modified microRNA operon. Dev Biol (2006) 1.83
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol (2002) 1.80
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development (2002) 1.77
Nodal signaling in early vertebrate embryos: themes and variations. Dev Cell (2001) 1.74
Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest (2004) 1.74
The floor plate: multiple cells, multiple signals. Nat Rev Neurosci (2005) 1.71
The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell (2006) 1.67
The developmental fate of the cephalic mesoderm in quail-chick chimeras. Development (1992) 1.65
The molecular genetics of holoprosencephaly. Am J Med Genet C Semin Med Genet (2010) 1.57
Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell (2008) 1.57
Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell (1993) 1.57
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev (2001) 1.54
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development (1999) 1.52
A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo. Dev Biol (2006) 1.50
Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Cell (1997) 1.49
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev (2001) 1.47
Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord. Development (1999) 1.39
The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature (1991) 1.39
Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol (2002) 1.37
A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development (1997) 1.32
The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm. Development (2003) 1.31
Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev Biol (1994) 1.24
Nodal signaling patterns the organizer. Development (2000) 1.22
Nodal stability determines signaling range. Curr Biol (2005) 1.21
Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation. Dev Cell (2006) 1.18
The morphogen signaling network in forebrain development and holoprosencephaly. J Neuropathol Exp Neurol (2007) 1.17
The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse. J Neurosci (2009) 1.17
Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. Development (2000) 1.14
The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. Cell (1993) 1.14
Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Proc Natl Acad Sci U S A (2004) 1.13
Directed differentiation of neural cells to hypothalamic dopaminergic neurons. Development (2005) 1.13
Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Dev Biol (1998) 1.12
Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo. Mech Dev (2000) 1.11
The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity. Neuron (2001) 1.10
Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development (2005) 1.10
Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway. PLoS Genet (2012) 1.10
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation. EMBO J (2008) 1.09
Patterning of the chick forebrain anlage by the prechordal plate. Development (1997) 1.08
Spatially distinct head and heart inducers within the Xenopus organizer region. Curr Biol (1999) 1.07
Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol (2008) 1.04
Comparison of the expression patterns of several fibroblast growth factors during chick gastrulation and neurulation. Anat Embryol (Berl) (2002) 1.03
Distinct modes of floor plate induction in the chick embryo. Development (2003) 1.02
A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor. Development (2003) 1.02
Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development. Development (2002) 1.01
Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. Development (2004) 1.00
Effects of heterodimerization and proteolytic processing on Derrière and Nodal activity: implications for mesoderm induction in Xenopus. Development (2002) 0.98
Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Dev Dyn (2010) 0.94
Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin. Development (1999) 0.94
The role of Sonic hedgehog in neural tube patterning. Cell Mol Life Sci (2000) 0.93
Factors controlling fibroblast growth factor receptor-1's cytoplasmic trafficking and its regulation as revealed by FRAP analysis. Mol Biol Cell (2006) 0.93
Early mammillary pouch specification in the course of prechordal ventralization of the forebrain tegmentum. Dev Biol (2008) 0.91
Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development (2013) 0.89
Development of the medial hypothalamus: forming a functional hypothalamic-neurohypophyseal interface. Curr Top Dev Biol (2013) 0.88
Regulation of thalamic development by sonic hedgehog. Front Neurosci (2012) 0.87
The role of prechordal mesendoderm in neural patterning. Curr Opin Neurobiol (2001) 0.87
Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry. PLoS Genet (2013) 0.87
The avian prechordal head region: a morphological study. J Anat (1993) 0.84
BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. Hum Mol Genet (2010) 0.84
Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos. Dev Dyn (2011) 0.83
The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities. Development (2008) 0.83
Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling. Development (2000) 0.82
Ontogeny of avian extrinsic ocular muscles. I. A light- and electron-microscopic study. Cell Tissue Res (1984) 0.82
Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking. Traffic (2009) 0.81
Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord. Development (2010) 0.80
An experimental system for analyzing response to a morphogen gradient. Proc Natl Acad Sci U S A (1996) 0.80
Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity. Biochem Biophys Res Commun (2010) 0.79
On the differentiation and origin of myoid cells in the avian thymus. Anat Embryol (Berl) (1990) 0.78
NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos. Dis Model Mech (2012) 0.78
Inhibition of FGF signaling converts dorsal mesoderm to ventral mesoderm in early Xenopus embryos. Differentiation (2011) 0.76