Published in Genes Dev on August 15, 2003
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol (2004) 2.41
A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev (2009) 1.98
Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol (2008) 1.79
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proc Natl Acad Sci U S A (2005) 1.68
Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. J Virol (2006) 1.67
Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways. J Virol (2005) 1.58
Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1. J Cell Biol (2004) 1.54
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes. Curr Opin Immunol (2012) 1.51
Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations. Proc Natl Acad Sci U S A (2008) 1.45
Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A (2008) 1.43
Apical role for BRG1 in cytokine-induced promoter assembly. Proc Natl Acad Sci U S A (2005) 1.30
Biology and significance of the JAK/STAT signalling pathways. Growth Factors (2012) 1.29
The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1. J Virol (2007) 1.29
Getting the message across, STAT! Design principles of a molecular signaling circuit. J Cell Biol (2004) 1.25
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene (2009) 1.24
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas. Immunology (2005) 1.23
Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol (2011) 1.13
Stat1 and SUMO modification. Blood (2006) 1.12
Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5. J Mol Biol (2010) 1.12
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J Biol Chem (2011) 1.11
STATs get their move on. JAKSTAT (2013) 1.08
Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB. J Virol (2009) 1.08
STAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinol (2013) 1.04
Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway. JAKSTAT (2013) 1.04
Activated STAT1 transcription factors conduct distinct saltatory movements in the cell nucleus. Biophys J (2011) 0.97
Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ. PLoS Pathog (2011) 0.95
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Mol Cancer (2015) 0.94
Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning. EMBO J (2010) 0.88
STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Mol Cell Biol (2011) 0.88
Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Infect Immun (2013) 0.87
Complex systems biology approach to understanding coordination of JAK-STAT signaling. Biosystems (2007) 0.87
Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression. Immunology (2010) 0.84
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest (2016) 0.81
Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar). BMC Immunol (2010) 0.81
Model-based extension of high-throughput to high-content data. BMC Syst Biol (2010) 0.79
Computational models of the JAK1/2-STAT1 signaling. JAKSTAT (2013) 0.78
Evidence against a role for β-arrestin1 in STAT1 dephosphorylation and the inhibition of interferon-γ signaling. Mol Cell (2013) 0.77
Two glutamic acid residues in the DNA-binding domain are engaged in the release of STAT1 dimers from DNA. BMC Cell Biol (2012) 0.77
A conserved motif in the linker domain of STAT1 transcription factor is required for both recognition and release from high-affinity DNA-binding sites. PLoS One (2014) 0.76
Properties of STAT1 and IRF1 enhancers and the influence of SNPs. BMC Mol Biol (2017) 0.75
Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity. Proc Natl Acad Sci U S A (2015) 0.75
DNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers. BMC Biochem (2014) 0.75
Overexpression of Semaphorin-3E enhances pancreatic cancer cell growth and associates with poor patient survival. Oncotarget (2016) 0.75
A rapid conformational rearrangement of STAT1 dimers is required for termination rather than for amplification of interferon-γ signaling. JAKSTAT (2013) 0.75
Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription. Mol Cell Biol (2014) 0.75
Go in! Go out! Inducible control of nuclear localization. Curr Opin Chem Biol (2016) 0.75
VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling. J Virol (2016) 0.75
Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-β-treated human macrophages. J Neurovirol (2016) 0.75
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 26.02
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. Biophys J (1976) 25.12
STATs and gene regulation. Science (1997) 16.55
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells. Science (2000) 6.17
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res (1998) 6.11
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell (1994) 5.79
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (1992) 5.71
Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B. J Cell Biol (2001) 4.96
Signal transduction and the control of gene expression. Science (2002) 4.38
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene (2002) 4.15
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev (1995) 4.11
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell (1998) 3.79
The general affinity of lac repressor for E. coli DNA: implications for gene regulation in procaryotes and eucaryotes. Cell (1975) 3.73
Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol (2002) 3.57
Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science (1996) 3.31
Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J (1997) 2.80
Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol (1991) 2.59
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J (1996) 2.50
GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J Interferon Cytokine Res (1997) 2.40
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J (2000) 2.24
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc Natl Acad Sci U S A (2000) 2.20
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. Proc Natl Acad Sci U S A (1999) 2.07
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J (2002) 2.01
Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J (2002) 2.01
Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity (1995) 2.00
Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J Biol Chem (2002) 1.86
Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. J Biol Chem (2001) 1.68
A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation. Mol Cell Biol (1999) 1.62
Regulation of interferon-alpha responsiveness by the duration of Janus kinase activity. J Biol Chem (1997) 1.48
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3. Exp Cell Res (2002) 1.44
Cytoplasmic transport of Stat3 by receptor-mediated endocytosis. EMBO J (2002) 1.43
STAT1 from the cell membrane to the DNA. EMBO J (2001) 1.36
Transcriptional activation: risky business. Genes Dev (2001) 1.32
Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. J Biol Chem (2002) 1.28
Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant. J Biol Chem (2002) 1.26
Signaling by the cytokine receptor superfamily. Ann N Y Acad Sci (1998) 1.22
A functional DNA binding domain is required for growth hormone-induced nuclear accumulation of Stat5B. J Biol Chem (1999) 1.19
Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol Endocrinol (1999) 1.18
The T-cell protein tyrosine phosphatase. Semin Immunol (2000) 1.17
Design of conditionally active STATs: insights into STAT activation and gene regulatory function. Mol Cell Biol (1999) 1.11
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem (2002) 1.10
Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J Biol Chem (1998) 1.08
The noncatalytic C-terminal segment of the T cell protein tyrosine phosphatase regulates activity via an intramolecular mechanism. J Biol Chem (1997) 1.02
The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site. J Cell Sci (2000) 0.96
JAKs, STATs and signal transduction in response to the interferons and other cytokines. Philos Trans R Soc Lond B Biol Sci (1996) 0.90
Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J (2002) 2.01
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep (2007) 1.72
A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic (2006) 1.62
Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1. J Cell Biol (2004) 1.54
Nucleocytoplasmic shuttling of STAT transcription factors. Eur J Biochem (2004) 1.54
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol (2006) 1.50
Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations. Proc Natl Acad Sci U S A (2008) 1.45
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3. Exp Cell Res (2002) 1.44
Small-molecule screening identifies modulators of aquaporin-2 trafficking. J Am Soc Nephrol (2013) 1.41
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem (2004) 1.39
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms. FEBS Lett (2004) 1.35
A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors. J Biol Chem (2004) 1.34
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33
Nuclear export determines the cytokine sensitivity of STAT transcription factors. J Biol Chem (2005) 1.18
Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol (2010) 1.16
Development of novel immunoglobulin G (IgG), IgA, and IgM enzyme immunoassays based on recombinant Puumala and Dobrava hantavirus nucleocapsid proteins. Clin Vaccine Immunol (2006) 1.15
Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5. J Mol Biol (2010) 1.12
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J Exp Med (2004) 1.12
The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide. J Biol Chem (2006) 1.11
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J Biol Chem (2011) 1.11
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J (2011) 1.10
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood (2011) 1.08
Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells. Am J Physiol Cell Physiol (2007) 1.02
Dimerization of corticotropin-releasing factor receptor type 1 is not coupled to ligand binding. J Recept Signal Transduct Res (2005) 1.02
[7-(Dialkylamino)coumarin-4-yl]methyl-Caged Compounds as Ultrafast and Effective Long-Wavelength Phototriggers of 8-Bromo-Substituted Cyclic Nucleotides. Chembiochem (2003) 1.01
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho. J Cell Sci (2003) 1.01
Dysferlin-deficient muscular dystrophy features amyloidosis. Ann Neurol (2008) 1.01
Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2). Proc Natl Acad Sci U S A (2010) 1.00
Critical illness myopathy and GLUT4: significance of insulin and muscle contraction. Am J Respir Crit Care Med (2012) 0.98
Coumarinylmethyl esters for ultrafast release of high concentrations of cyclic nucleotides upon one- and two-photon photolysis. Angew Chem Int Ed Engl (2005) 0.97
Activated STAT1 transcription factors conduct distinct saltatory movements in the cell nucleus. Biophys J (2011) 0.97
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. Eur J Cell Biol (2006) 0.96
Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice. Arch Biochem Biophys (2006) 0.96
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem (2009) 0.96
The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity. J Biol Chem (2010) 0.94
Arginine methylation of STAT1: a reassessment. Cell (2004) 0.94
TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression. J Immunol (2006) 0.93
Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One (2012) 0.92
Aquaporin-1, nothing but a water channel. J Biol Chem (2003) 0.92
Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. J Cell Sci (2009) 0.91
Green fluorescent protein-tagging reduces the nucleocytoplasmic shuttling specifically of unphosphorylated STAT1. FEBS J (2007) 0.90
STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Mol Cell Biol (2011) 0.88
Structural insights into the mechanism of GTPase activation in the GIMAP family. Structure (2013) 0.88
Caged progesterone: a new tool for studying rapid nongenomic actions of progesterone. J Am Chem Soc (2009) 0.88
Dysferlin-deficient immortalized human myoblasts and myotubes as a useful tool to study dysferlinopathy. PLoS Curr (2012) 0.87
DMACM-caged adenosine nucleotides: ultrafast phototriggers for ATP, ADP, and AMP activated by long-wavelength irradiation. Chembiochem (2003) 0.87
STAT nuclear translocation: potential for pharmacological intervention. Expert Opin Ther Targets (2007) 0.86
New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR. J Clin Endocrinol Metab (2011) 0.85
Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides. J Biol Chem (2007) 0.84
Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations. Chemistry (2012) 0.84
Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors. Mol Pharmacol (2007) 0.84
Photocontrol of contracting muscle fibers. Angew Chem Int Ed Engl (2011) 0.83
(Coumarin-4-yl)methyl esters as highly efficient, ultrafast phototriggers for protons and their application to acidifying membrane surfaces. Angew Chem Int Ed Engl (2005) 0.83
Microinjected antibodies interfere with protein nucleocytoplasmic shuttling by distinct molecular mechanisms. Cytometry A (2008) 0.83
Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide. Eur J Biochem (2004) 0.83
Use of Kaede fusions to visualize recycling of G protein-coupled receptors. Traffic (2008) 0.83
Routes of epithelial water flow: aquaporins versus cotransporters. Biophys J (2010) 0.82
Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest (2014) 0.82
Impact of membrane properties on uptake and transcytosis of colloidal nanocarriers across an epithelial cell barrier model. J Pharm Sci (2010) 0.81
STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition. Nucleic Acids Res (2012) 0.81
{7-[Bis(carboxymethyl)amino]coumarin-4-yl}methoxycarbonyl derivatives for photorelease of carboxylic acids, alcohols/phenols, thioalcohols/thiophenols, and amines. Chemistry (2008) 0.81
Fluorescence spectroscopic quantification of the release of cyclic nucleotides from photocleavable [bis(carboxymethoxy)coumarin-4-yl]methyl esters inside cells. Angew Chem Int Ed Engl (2002) 0.81
Nuclear localization of the zebrafish tight junction protein nagie oko. Dev Dyn (2008) 0.81
Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J Biol Chem (2011) 0.81
Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation. FEBS J (2014) 0.81
Culturing primary rat inner medullary collecting duct cells. J Vis Exp (2013) 0.80
The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization. J Biol Chem (2012) 0.80
Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE. Biol Chem (2008) 0.79
Studies on the cellular uptake of substance P and lysine-rich, KLA-derived model peptides. J Mol Recognit (2004) 0.79
Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge. Int J Biol Macromol (2013) 0.78
Dysferlin-peptides reallocate mutated dysferlin thereby restoring function. PLoS One (2012) 0.78
Use of Kikume green-red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors. FEBS Lett (2012) 0.78
Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells. Mol Pharm (2013) 0.78
Live cell imaging of G protein-coupled receptors. Methods Mol Biol (2012) 0.77
Evidence against a role for β-arrestin1 in STAT1 dephosphorylation and the inhibition of interferon-γ signaling. Mol Cell (2013) 0.77
Use of Kaede and Kikume green-red fusions for live cell imaging of G protein-coupled receptors. Methods Mol Biol (2014) 0.77
Assessing sequence-specific DNA binding and transcriptional activity of STAT1 transcription factor. Methods Mol Biol (2010) 0.76
Coumarin-based octopamine phototriggers and their effects on an insect octopamine receptor. Chembiochem (2012) 0.76
Paracrystals of STAT proteins and their dissolution by SUMO: how reduced transcription factor solubility increases cytokine signaling. Oncotarget (2011) 0.75
Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability. J Pept Sci (2010) 0.75
Characterization of STAT self-association by analytical ultracentrifugation. Methods Mol Biol (2013) 0.75
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J Biol Chem (2017) 0.75
Growth factor- and adhesion protein-like components of fetal calf serum can significantly enhance the intracellular delivery of Peptide nucleic acids. Nucleic Acid Ther (2011) 0.75