Published in FEBS Lett on October 08, 2004
Nuclear export of proteins and drug resistance in cancer. Biochem Pharmacol (2011) 2.43
An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells. Cell Cycle (2012) 2.00
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia (2012) 1.77
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol (2013) 1.68
Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response. PLoS Pathog (2010) 1.46
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochem J (2012) 1.36
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc Natl Acad Sci U S A (2013) 1.21
Nucleo-cytoplasmic transport as a therapeutic target of cancer. J Hematol Oncol (2014) 1.19
Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition. Cancer Res (2009) 1.12
Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol (2014) 1.11
The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. Nucleic Acids Res (2007) 1.10
Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol (2014) 1.01
Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors. J Comput Aided Mol Des (2012) 0.99
CRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo. J Cancer (2013) 0.94
The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. J Biol Chem (2010) 0.92
Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther (2015) 0.91
Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway. J Biol Chem (2010) 0.91
Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport. Bioorg Med Chem (2010) 0.90
Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts. PLoS One (2014) 0.87
The high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic. Virology (2011) 0.85
Characterization of the transport signals that mediate the nucleocytoplasmic traffic of low risk HPV11 E7. Virology (2013) 0.84
Intrinsic and extrinsic negative regulators of nuclear protein transport processes. Genes Cells (2012) 0.80
Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics. Sensors (Basel) (2009) 0.79
The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway. Microb Cell Fact (2014) 0.77
Structural Basis of Targeting the Exportin CRM1 in Cancer. Cells (2015) 0.77
STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways. PLoS Biol (2016) 0.76
Nuclear export of cutaneous HPV8 E7 oncoprotein is mediated by a leucine-rich nuclear export signal via a CRM1 pathway. Virology (2014) 0.75
Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver. Exp Ther Med (2016) 0.75
CRM1 Inhibitors for Antiviral Therapy. Front Microbiol (2017) 0.75
Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer. J Thorac Oncol (2017) 0.75
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J (2002) 2.01
Genetic analysis of the mouse brain proteome. Nat Genet (2002) 1.73
DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev (2003) 1.68
Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1. J Cell Biol (2004) 1.54
Nucleocytoplasmic shuttling of STAT transcription factors. Eur J Biochem (2004) 1.54
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol (2006) 1.50
Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations. Proc Natl Acad Sci U S A (2008) 1.45
Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions. J Proteome Res (2011) 1.45
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3. Exp Cell Res (2002) 1.44
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proc Natl Acad Sci U S A (2008) 1.43
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem (2004) 1.39
A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors. J Biol Chem (2004) 1.34
The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes. Nucleic Acids Res (2011) 1.30
A K+-selective cGMP-gated ion channel controls chemosensation of sperm. Nat Cell Biol (2006) 1.21
An atypical CNG channel activated by a single cGMP molecule controls sperm chemotaxis. Sci Signal (2009) 1.20
Nuclear export determines the cytokine sensitivity of STAT transcription factors. J Biol Chem (2005) 1.18
Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. Proc Natl Acad Sci U S A (2006) 1.17
Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolism. Mol Cell Proteomics (2005) 1.15
Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5. J Mol Biol (2010) 1.12
Identification of phosphorylation-dependent interaction partners of the adapter protein ADAP using quantitative mass spectrometry: SILAC vs (18)O-labeling. J Proteome Res (2010) 1.12
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J Biol Chem (2011) 1.11
Mass-spectrometric identification of a novel angiotensin peptide in human plasma. Arterioscler Thromb Vasc Biol (2006) 1.10
Actin remodeling requires ERM function to facilitate AQP2 apical targeting. J Cell Sci (2005) 1.10
Protein networks supporting AP-3 function in targeting lysosomal membrane proteins. Mol Biol Cell (2008) 1.09
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood (2011) 1.08
Disease-causing V(2) vasopressin receptors are retained in different compartments of the early secretory pathway. Traffic (2004) 1.06
Galpha(s) is palmitoylated at the N-terminal glycine. EMBO J (2003) 1.06
Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth. Mol Biol Cell (2008) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma. J Biol Chem (2002) 1.04
Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reoxygenation. Proteomics (2006) 1.04
Comparative study of protein and mRNA expression during osteoclastogenesis. Proteomics (2005) 1.02
Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res (2007) 1.02
Chaperones specific for the membrane-bound [NiFe]-hydrogenase interact with the Tat signal peptide of the small subunit precursor in Ralstonia eutropha H16. Mol Microbiol (2007) 1.01
Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts. Proc Natl Acad Sci U S A (2009) 1.01
Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes. J Biol Chem (2010) 1.01
Dysferlin-deficient muscular dystrophy features amyloidosis. Ann Neurol (2008) 1.01
Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A (2012) 1.00
Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. Angew Chem Int Ed Engl (2015) 0.98
Activated STAT1 transcription factors conduct distinct saltatory movements in the cell nucleus. Biophys J (2011) 0.97
Retracted PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling. Genes Dev (2009) 0.96
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells. PLoS One (2010) 0.96
Quantitative proteomics analysis of detergent-resistant membranes from chemical synapses: evidence for cholesterol as spatial organizer of synaptic vesicle cycling. Mol Cell Proteomics (2006) 0.95
Fractionation and identification of proteins by 2-DE and MS: towards a proteomic analysis of Plasmodium falciparum. Proteomics (2005) 0.95
Arginine methylation of STAT1: a reassessment. Cell (2004) 0.94
The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.94
Developmentally induced changes of the proteome in the protozoan parasite Leishmania donovani. Proteomics (2003) 0.93
Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study. Aquat Toxicol (2005) 0.93
The bacterial translocon SecYEG opens upon ribosome binding. J Biol Chem (2013) 0.93
Switch-peptides to trigger the peptide guided assembly of poly(ethylene oxide)-peptide conjugates into tape structures. J Am Chem Soc (2006) 0.92
Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm. J Cell Biol (2012) 0.91
Green fluorescent protein-tagging reduces the nucleocytoplasmic shuttling specifically of unphosphorylated STAT1. FEBS J (2007) 0.90
Evaluation of the titanium dioxide approach for MS analysis of phosphopeptides. J Mass Spectrom (2006) 0.89
Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina. Aquat Toxicol (2003) 0.89
Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties. Proteomics (2009) 0.89
Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579. Cell Signal (2006) 0.89
The cell surface proteome of Entamoeba histolytica. Mol Cell Proteomics (2013) 0.89
STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Mol Cell Biol (2011) 0.88
Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome. J Biol Chem (2011) 0.88
Proline-rich sequence recognition: I. Marking GYF and WW domain assembly sites in early spliceosomal complexes. Mol Cell Proteomics (2009) 0.87
Rational design of oligopeptide organizers for the formation of poly(ethylene oxide) nanofibers. Chem Commun (Camb) (2005) 0.87
Protective effects of peroxiredoxin-1 at the injured blood-brain barrier. Free Radic Biol Med (2008) 0.87
Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein. Biochim Biophys Acta (2008) 0.87
Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem Cell Biol (2008) 0.87
Structural characterization of the acid-degraded secondary cell wall polymer of Geobacillus stearothermophilus PV72/p2. Carbohydr Res (2008) 0.87
Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15. FEBS J (2014) 0.87
Angioprotectin: an angiotensin II-like peptide causing vasodilatory effects. FASEB J (2011) 0.86
STAT nuclear translocation: potential for pharmacological intervention. Expert Opin Ther Targets (2007) 0.86
Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides. Eur J Pharmacol (2008) 0.86
Solid-phase supported polymer synthesis of sequence-defined, multifunctional poly(amidoamines). Biomacromolecules (2006) 0.86
Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals. Antioxid Redox Signal (2015) 0.85
Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci (2013) 0.85
Reversible disulfide bond formation of intracellular proteins probed by NMR spectroscopy. Free Radic Biol Med (2007) 0.85
Impact of N-terminal domains for corticotropin-releasing factor (CRF) receptor-ligand interactions. Biochemistry (2005) 0.85
Accessibility of cysteines in the native bovine rod cGMP-gated channel. Biochemistry (2005) 0.85
Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions. Mol Cell Proteomics (2009) 0.85
Depsipeptide methodology for solid-phase peptide synthesis: circumventing side reactions and development of an automated technique via depsidipeptide units. J Org Chem (2006) 0.85
Hexa-histidin tag position influences disulfide structure but not binding behavior of in vitro folded N-terminal domain of rat corticotropin-releasing factor receptor type 2a. Protein Sci (2004) 0.85
Membrane destabilization by ricin. Eur Biophys J (2004) 0.84
Effects of thawing, refreezing and storage conditions of tissue samples and protein extracts on 2-DE spot intensity. Proteomics (2010) 0.84
Derivatization of phosphorylated peptides with S- and N-nucleophiles for enhanced ionization efficiency in matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.84
Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors. Mol Pharmacol (2007) 0.84
CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genet (2013) 0.84
The cellular protein lyric interacts with HIV-1 Gag. J Virol (2011) 0.84
Hydrogen exchange studies on Alzheimer's amyloid-beta peptides by mass spectrometry using matrix-assisted laser desorption/ionization and electrospray ionization. Rapid Commun Mass Spectrom (2003) 0.83
Microinjected antibodies interfere with protein nucleocytoplasmic shuttling by distinct molecular mechanisms. Cytometry A (2008) 0.83
Role of lipid rafts in membrane delivery of renal epithelial Na+-K+-ATPase, thick ascending limb. Am J Physiol Regul Integr Comp Physiol (2006) 0.83
The relative influence of phosphorylation and methylation on responsiveness of peptides to MALDI and ESI mass spectrometry. J Mass Spectrom (2009) 0.82
Proteome analysis of chemically induced mouse liver tumors with different genotype. Proteomics (2007) 0.82
Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. EMBO Rep (2012) 0.82
Site-specifically phosphorylated lysine peptides. J Am Chem Soc (2014) 0.82
A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein. Proteomics (2009) 0.82
CIN85 interacting proteins in B cells-specific role for SHIP-1. Mol Cell Proteomics (2011) 0.82
Analysis of rotavirus non-structural protein NSP5 by mass spectrometry reveals a complex phosphorylation pattern. Virus Res (2009) 0.81
STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition. Nucleic Acids Res (2012) 0.81
Relative quantification of erythropoietin receptor-dependent phosphoproteins using in-gel 18O-labeling and tandem mass spectrometry. Rapid Commun Mass Spectrom (2005) 0.81
Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes. Structure (2010) 0.81
Differential signatures of protein expression in marmoset liver and thymus induced by single-dose TCDD treatment. Toxicology (2005) 0.80