Published in Biochemistry on August 26, 2003
Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation. Protein Sci (2006) 1.25
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest (2004) 1.21
Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322. Antimicrob Agents Chemother (2013) 1.00
Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis. Plant Cell (2011) 0.92
Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol (2009) 0.91
Inhibition of human peptide deformylase disrupts mitochondrial function. Mol Cell Biol (2010) 0.91
Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase. Arch Biochem Biophys (2007) 0.88
Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases. J Bacteriol (2006) 0.87
Peptide deformylase inhibitors as potent antimycobacterial agents. Antimicrob Agents Chemother (2006) 0.87
Overexpression of peptide deformylase in breast, colon, and lung cancers. BMC Cancer (2013) 0.84
Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus. Antimicrob Agents Chemother (2006) 0.82
An improved crystal form of Plasmodium falciparum peptide deformylase. Protein Sci (2004) 0.82
Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activity. J Biol Chem (2008) 0.81
Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase. Biochim Biophys Acta (2009) 0.81
Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin. Biochemistry (2009) 0.80
Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor. Antimicrob Agents Chemother (2004) 0.79
Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Bioorg Med Chem Lett (2011) 0.79
In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. Antimicrob Agents Chemother (2009) 0.79
A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep (2016) 0.75
Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase (PDF) from Bacillus cereus in ligand-free and actinonin-bound forms. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.75
Insights from ligand and structure based methods in virtual screening of selective Ni-peptide deformylase inhibitors. J Mol Model (2011) 0.75
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem (2004) 2.71
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood (2002) 2.16
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking. Curr Biol (2010) 1.84
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J Biol Chem (2010) 1.74
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci U S A (2007) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer. J Biol Chem (2003) 1.66
A chemical approach to the identification of tensin-binding proteins. ACS Chem Biol (2007) 1.61
Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains. Biochemistry (2005) 1.50
Cell-permeable bicyclic peptide inhibitors against intracellular proteins. J Am Chem Soc (2014) 1.49
High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry. J Am Chem Soc (2006) 1.45
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Traceless capping agent for peptide sequencing by partial edman degradation and mass spectrometry. Anal Chem (2006) 1.42
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem (2006) 1.39
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem (2008) 1.35
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem (2004) 1.32
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci (2009) 1.31
Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol (2006) 1.31
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology (2009) 1.31
On-bead screening of combinatorial libraries: reduction of nonspecific binding by decreasing surface ligand density. J Comb Chem (2009) 1.26
S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein. Biochemistry (2003) 1.24
The selectivity filter of the cation channel TRPM4. J Biol Chem (2005) 1.24
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. Pflugers Arch (2009) 1.19
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch (2005) 1.17
Task-based optimization and performance assessment in optical coherence imaging. J Opt Soc Am A Opt Image Sci Vis (2005) 1.16
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues. J Am Chem Soc (2009) 1.15
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J Biol Chem (2005) 1.15
Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development. J Proteome Res (2013) 1.15
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proc Natl Acad Sci U S A (2013) 1.14
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen (2010) 1.14
An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels. J Biol Chem (2004) 1.14
Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2. Biochemistry (2011) 1.13
Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer. Mol Cancer (2007) 1.12
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci (2011) 1.12
High-throughput sequencing of peptoids and peptide-peptoid hybrids by partial edman degradation and mass spectrometry. J Comb Chem (2009) 1.11
Catalytic mechanism of S-ribosylhomocysteinase (LuxS): direct observation of ketone intermediates by 13C NMR spectroscopy. J Am Chem Soc (2003) 1.11
Substrate profiling of protein tyrosine phosphatase PTP1B by screening a combinatorial peptide library. J Am Chem Soc (2007) 1.10
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol (2005) 1.08
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Biochemistry (2010) 1.08
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. Circ Res (2005) 1.07
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect Immun (2002) 1.06
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. J Biol Chem (2011) 1.06
Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate. Biochemistry (2005) 1.06
Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem (2010) 1.05
Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position. J Biol Chem (2006) 1.04
An improved method for rapid sequencing of support-bound peptides by partial edman degradation and mass spectrometry. J Comb Chem (2003) 1.04
Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs. ACS Chem Biol (2012) 1.04
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors. J Pharmacol Exp Ther (2010) 1.03
Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol (2006) 1.03
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Cell Calcium (2007) 1.02
Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response. J Biol Chem (2011) 1.01
Hysteresis of gating underlines sensitization of TRPV3 channels. J Gen Physiol (2011) 1.01
Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase. J Med Chem (2006) 1.00
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development. Mol Pharmacol (2007) 1.00
High-throughput synthesis and screening of cyclic peptide antibiotics. J Med Chem (2007) 0.99
Catalytic mechanism of S-ribosylhomocysteinase (LuxS): stereochemical course and kinetic isotope effect of proton transfer reactions. Biochemistry (2004) 0.99
High-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction. ACS Comb Sci (2011) 0.99
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol (2010) 0.99
Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. J Pharmacol Exp Ther (2008) 0.98
Macrocyclic inhibitors for peptide deformylase: a structure-activity relationship study of the ring size. J Med Chem (2004) 0.98
The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G. J Neurosci (2007) 0.97
Synthesis and screening of support-bound combinatorial peptide libraries with free C-termini: determination of the sequence specificity of PDZ domains. Biochemistry (2008) 0.97
Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery. Biochemistry (2014) 0.97
Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1. J Med Chem (2010) 0.97
Potential involvement of extracellular signal-regulated kinase 1 and 2 in encystation of a primitive eukaryote, Giardia lamblia. Stage-specific activation and intracellular localization. J Biol Chem (2002) 0.96
Altered -3 substrate specificity of Escherichia coli signal peptidase 1 mutants as revealed by screening a combinatorial peptide library. J Biol Chem (2006) 0.95
Synthesis and screening of a cyclic peptide library: discovery of small-molecule ligands against human prolactin receptor. Bioorg Med Chem (2008) 0.95
Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions. J Cell Sci (2010) 0.94
PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci (2012) 0.94
Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum. Mol Biochem Parasitol (2007) 0.93
Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position. Bioorg Med Chem (2009) 0.93
Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design. Structure (2002) 0.92
Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries. Methods (2007) 0.92
Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. J Neurosci (2013) 0.92
Cyclic peptidyl inhibitors of Grb2 and tensin SH2 domains identified from combinatorial libraries. J Comb Chem (2008) 0.92
A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process. Cell Cycle (2012) 0.91
In-fiber production of polymeric particles for biosensing and encapsulation. Proc Natl Acad Sci U S A (2013) 0.90
A LuxP-based fluorescent sensor for bacterial autoinducer II. ACS Chem Biol (2008) 0.90
Real-time fit of a respirator during simulated health care tasks. J Occup Environ Hyg (2012) 0.90
Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem (2013) 0.90
TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis. J Neurophysiol (2011) 0.89
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell. Islets (2010) 0.89
Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase. Arch Biochem Biophys (2007) 0.88
S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit. Bioorg Med Chem (2008) 0.88
trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases. Biochemistry (2004) 0.88
Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy. Biochem J (2006) 0.87
Androgen regulates Cdc6 transcription through interactions between androgen receptor and E2F transcription factor in prostate cancer cells. Biochim Biophys Acta (2008) 0.87
Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring. Bioorg Med Chem (2011) 0.86