Published in Blood on October 15, 2002
Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol (2010) 2.43
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J Exp Med (2008) 1.74
CRAC channelopathies. Pflugers Arch (2010) 1.71
Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet. J Thromb Haemost (2007) 1.65
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells. Eur J Neurosci (2006) 1.52
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch (2005) 1.40
Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. J Physiol (2006) 1.38
Physiological mechanisms of TRPC activation. Pflugers Arch (2005) 1.31
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest (2007) 1.20
R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood (2008) 1.19
Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.15
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am J Physiol Renal Physiol (2010) 1.14
Functional role of TRPC channels in the regulation of endothelial permeability. Pflugers Arch (2005) 1.13
Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. Pflugers Arch (2008) 1.12
The physiological function of store-operated calcium entry. Neurochem Res (2011) 1.05
Emerging roles of store-operated Ca²⁺ entry through STIM and ORAI proteins in immunity, hemostasis and cancer. Channels (Austin) (2013) 1.00
Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation (2012) 0.99
Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. J Biol Chem (2010) 0.97
Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte. J Physiol (2006) 0.96
Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry. Biochem J (2003) 0.92
Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem (2010) 0.92
cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem (2011) 0.92
Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2). J Biol Chem (2013) 0.91
Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells. Am J Physiol Endocrinol Metab (2011) 0.90
Expression profiling and electrophysiological studies suggest a major role for Orai1 in the store-operated Ca2+ influx pathway of platelets and megakaryocytes. Platelets (2008) 0.89
Role of transient receptor potential canonical 6 (TRPC6) in non-transferrin-bound iron uptake in neuronal phenotype PC12 cells. Biochem J (2004) 0.88
The importance of calcium in the regulation of megakaryocyte function. Haematologica (2014) 0.87
Hyperforin activates nonselective cation channels (NSCCs). Br J Pharmacol (2005) 0.84
Human endogenous retrovirus HERV-K14 families: status, variants, evolution, and mobilization of other cellular sequences. J Virol (2005) 0.83
The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets. Cell Signal (2013) 0.80
Protonophore properties of hyperforin are essential for its pharmacological activity. Sci Rep (2014) 0.79
TRP channels and calcium entry in human platelets. Blood (2002) 0.79
Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway. J Physiol (2014) 0.79
Expression of transient receptor potential channel 6 in cervical cancer. Onco Targets Ther (2012) 0.79
Increasing the expression of calcium-permeable TRPC3 and TRPC7 channels enhances constitutive secretion. Biochem J (2008) 0.79
Rapid agonist-evoked coupling of type II Ins(1,4,5)P3 receptor with human transient receptor potential (hTRPC1) channels in human platelets. Biochem J (2003) 0.78
A critical role for the transient receptor potential channel type 6 in human platelet activation. PLoS One (2015) 0.78
The serine 814 of TRPC6 is phosphorylated under unstimulated conditions. PLoS One (2011) 0.77
PAR-1-stimulated factor IXa binding to a small platelet subpopulation requires a pronounced and sustained increase of cytoplasmic calcium. Biochemistry (2006) 0.77
Impaired calcium entry into cells is associated with pathological signs of zinc deficiency. Adv Nutr (2013) 0.76
Chronic hypoxia increases TRPC6 expression and basal intracellular Ca2+ concentration in rat distal pulmonary venous smooth muscle. PLoS One (2014) 0.76
Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier. Cell Calcium (2010) 0.76
(Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.76
Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines. Thromb Haemost (2016) 0.75
Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase. Intensive Care Med Exp (2015) 0.75
NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A(2) synthesis and calcium entry. Br J Pharmacol (2011) 0.75
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
The TRP channels, a remarkably functional family. Cell (2002) 4.06
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res (2002) 3.05
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol (2008) 2.71
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem (2004) 2.71
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
TRPC3 channels are required for synaptic transmission and motor coordination. Neuron (2008) 2.30
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad Sci U S A (2008) 2.11
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A (2010) 1.85
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking. Curr Biol (2010) 1.84
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J Biol Chem (2010) 1.74
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci U S A (2007) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol (2007) 1.68
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes. J Biol Chem (2003) 1.53
Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem (2005) 1.52
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels. J Biol Chem (2007) 1.42
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med (2009) 1.42
A role for the thiol isomerase protein ERP5 in platelet function. Blood (2004) 1.41
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem (2006) 1.39
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem (2008) 1.35
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem (2004) 1.32
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene (2003) 1.31
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci (2009) 1.31
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology (2009) 1.31
Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol (2006) 1.31
Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol (2005) 1.28
Characterization of a human peptide deformylase: implications for antibacterial drug design. Biochemistry (2003) 1.27
Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem (2006) 1.26
Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae. J Biol Chem (2002) 1.26
Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci U S A (2003) 1.25
Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res (2006) 1.24
The selectivity filter of the cation channel TRPM4. J Biol Chem (2005) 1.24
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Physiol Rev (2014) 1.23
Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell (2004) 1.22
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. Pflugers Arch (2009) 1.19
A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein. Mol Cell Proteomics (2006) 1.17
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch (2005) 1.17
Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem (2004) 1.17
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol (2012) 1.16
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J Biol Chem (2005) 1.15
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen (2010) 1.14
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proc Natl Acad Sci U S A (2013) 1.14
An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels. J Biol Chem (2004) 1.14
Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium (2007) 1.13
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci (2011) 1.12
Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. Pflugers Arch (2008) 1.12
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med (2012) 1.11
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A (2006) 1.11
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol (2005) 1.08
Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem (2002) 1.07
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest (2010) 1.07
Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem (2008) 1.07
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. Circ Res (2005) 1.07
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. J Biol Chem (2011) 1.06
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect Immun (2002) 1.06
TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochem Biophys Res Commun (2004) 1.05
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol (2012) 1.03
Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit. J Biol Chem (2003) 1.03
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors. J Pharmacol Exp Ther (2010) 1.03
Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol (2006) 1.03
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Cell Calcium (2007) 1.02
TRPV6 potentiates calcium-dependent cell proliferation. Cell Calcium (2005) 1.01
Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response. J Biol Chem (2011) 1.01
Hysteresis of gating underlines sensitization of TRPV3 channels. J Gen Physiol (2011) 1.01
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes. Cell Calcium (2007) 1.01
Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem (2009) 1.01
Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol (2011) 1.00
The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells. Mol Pharmacol (2011) 1.00
Altered inactivation of Ca2+ current and Ca2+ release in mouse muscle fibers deficient in the DHP receptor gamma1 subunit. J Gen Physiol (2004) 1.00
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development. Mol Pharmacol (2007) 1.00
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol (2010) 0.99
Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. J Pharmacol Exp Ther (2008) 0.98
The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G. J Neurosci (2007) 0.97
Male fertility depends on Ca²+ absorption by TRPV6 in epididymal epithelia. Sci Signal (2011) 0.95
Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions. J Cell Sci (2010) 0.94
PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci (2012) 0.94
Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. Nat Immunol (2009) 0.93
The TRPV6 gene, cDNA and protein. Cell Calcium (2003) 0.93
The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells. J Biol Chem (2002) 0.93
TRPM4 regulates migration of mast cells in mice. Cell Calcium (2008) 0.93
Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. J Neurosci (2013) 0.92
The auxiliary subunit gamma 1 of the skeletal muscle L-type Ca2+ channel is an endogenous Ca2+ antagonist. Proc Natl Acad Sci U S A (2007) 0.92