Published in Curr Biol on March 25, 2010
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science (2015) 2.14
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals. J Biol Chem (2010) 1.74
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J Biol Chem (2010) 1.74
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
Two-pore channels form homo- and heterodimers. J Biol Chem (2011) 1.67
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells. J Biol Chem (2011) 1.67
Structure and function of ER membrane contact sites with other organelles. Nat Rev Mol Cell Biol (2015) 1.44
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg. J Biol Chem (2011) 1.28
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP. FEBS Lett (2010) 1.26
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2. Mol Cell Biol (2014) 1.19
Retracted Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. J Biol Chem (2013) 1.16
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J Biol Chem (2010) 1.16
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle. J Biol Chem (2010) 1.10
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J (2015) 1.09
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. J Cell Sci (2014) 1.08
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles. J Cell Biol (2013) 1.08
NAADP receptors. Cold Spring Harb Perspect Biol (2011) 1.08
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1. J Biol Chem (2012) 1.04
Autophagic/lysosomal dysfunction in Alzheimer's disease. Alzheimers Res Ther (2013) 1.01
The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation. Proc Natl Acad Sci U S A (2014) 0.99
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium (2011) 0.97
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
Questioning regulation of two-pore channels by NAADP. Messenger (Los Angel) (2013) 0.93
Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes. J Biol Chem (2013) 0.92
Domain assembly of NAADP-gated two-pore channels. Biochem J (2012) 0.92
NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol Biol Cell (2014) 0.89
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells. J Biol Chem (2015) 0.89
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell. Islets (2010) 0.89
Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells. PLoS One (2014) 0.88
Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels. J Physiol (2016) 0.88
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway. MBio (2016) 0.87
Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes. J Biol Chem (2013) 0.86
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function. Brain Res (2012) 0.86
The Molecular Basis for Ca(2+) Signalling by NAADP: Two-Pore Channels in a Complex? Messenger (Los Angel) (2012) 0.86
Calcium signaling and the secretory activity of bile duct epithelia. Cell Calcium (2014) 0.84
Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol (2015) 0.84
Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells. PLoS One (2013) 0.83
Two-pore channels at the intersection of endolysosomal membrane traffic. Biochem Soc Trans (2015) 0.82
Ion transport in pigmentation. Arch Biochem Biophys (2014) 0.81
Synaptic plasticity and Ca2+ signalling in astrocytes. Neuron Glia Biol (2010) 0.79
The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release. Cell Calcium (2012) 0.78
Decoding calcium signaling across the nucleus. Physiology (Bethesda) (2014) 0.78
Calcium signaling in the liver. Compr Physiol (2013) 0.78
Calcium signaling in membrane repair. Semin Cell Dev Biol (2015) 0.78
Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions. Channels (Austin) (2016) 0.78
A melanosomal two-pore sodium channel regulates pigmentation. Sci Rep (2016) 0.77
Two-Pore Channels: Lessons from Mutant Mouse Models. Messenger (Los Angel) (2015) 0.77
Organelle-specific subunit interactions of the vertebrate two-pore channel family. J Biol Chem (2014) 0.77
Calcium pathway machinery at fertilization in echinoderms. Cell Calcium (2012) 0.77
Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis. Channels (Austin) (2015) 0.77
Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci U S A (2017) 0.76
On the move, lysosomal CAX drives Ca2+ transport and motility. J Cell Biol (2016) 0.76
Two-pore channels function in calcium regulation in sea star oocytes and embryos. Development (2014) 0.76
Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol (2013) 0.76
Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons. Cell Calcium (2015) 0.76
An Endosomal NAADP-Sensitive Two-Pore Ca(2+) Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling. Cell Rep (2017) 0.76
Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A. Autophagy (2016) 0.76
Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function. Front Pharmacol (2017) 0.75
The human two-pore channel 1 is modulated by cytosolic and luminal calcium. Sci Rep (2017) 0.75
Poring over two-pore channel pore mutants. Messenger (Los Angel) (2015) 0.75
Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci (2016) 0.75
Acidic Ca(2+) stores in neurodegeneration. Messenger (Los Angel) (2016) 0.75
IP3 receptor signaling and endothelial barrier function. Cell Mol Life Sci (2017) 0.75
Connecting Ca(2+) and lysosomes to Parkinson disease. Messenger (Los Angel) (2016) 0.75
Two-Pore Channels and Parkinson's Disease: Where's the Link? Messenger (Los Angel) (2016) 0.75
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med (2008) 3.86
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J Biol Chem (1995) 3.23
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell (2002) 3.16
The single-copy DNA sequence polymorphism of the sea urchin Strongylocentrotus purpuratus. Cell (1978) 3.06
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol (2009) 3.04
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells. Nature (1999) 2.72
Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool. Biochem J (1996) 2.70
Identification of a chemical probe for NAADP by virtual screening. Nat Chem Biol (2009) 2.54
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch (2009) 2.35
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol (2003) 1.80
Activation and inactivation of Ca2+ release by NAADP+. J Biol Chem (1996) 1.79
Unique inactivation properties of NAADP-sensitive Ca2+ release. J Biol Chem (1996) 1.78
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology. J Cell Sci (2002) 1.59
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem (2009) 1.42
The role of calcium and other ions in sorting and delivery in the late endocytic pathway. Biochem Soc Trans (2007) 1.40
Functional visualization of the separate but interacting calcium stores sensitive to NAADP and cyclic ADP-ribose. J Cell Sci (2000) 1.39
CUPpling calcium to lysosomal biogenesis. Trends Cell Biol (2004) 1.27
The NAADP receptor: new receptors or new regulation? Mol Interv (2005) 1.26
Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells. Cell Calcium (2007) 1.26
Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients. J Biol Chem (2000) 1.22
Characterization of NAADP(+) binding in sea urchin eggs. Biochem Biophys Res Commun (2000) 1.19
Generation of specific Ca(2+) signals from Ca(2+) stores and endocytosis by differential coupling to messengers. Curr Biol (2006) 1.17
NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes. FASEB J (2001) 1.04
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem Soc Trans (2006) 1.03
Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations. Biochem J (2003) 1.00
Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites. Curr Biol (2008) 1.00
Prolonged inactivation of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release mediates a spatiotemporal Ca2+ memory. J Biol Chem (2001) 0.99
Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization. J Biol Chem (2008) 0.95
Investigating cADPR and NAADP in intact and broken cell preparations. Methods (2008) 0.92
Fertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggs. J Biol Chem (2007) 0.92
Storage diseases: new insights into sphingolipid functions. Trends Cell Biol (2003) 0.84
Activation by serotonin of starfish eggs expressing the rat serotonin 1c receptor. Cell Regul (1990) 0.83
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med (2008) 3.86
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell (2002) 3.16
PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development (2002) 3.13
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature (2007) 3.13
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem (2004) 2.71
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med (2007) 2.57
Identification of a chemical probe for NAADP by virtual screening. Nat Chem Biol (2009) 2.54
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest (2008) 2.46
Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase. Nat Genet (2004) 2.45
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A (2007) 2.24
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood (2002) 2.16
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells. J Biol Chem (2003) 2.12
Targeting glycosylation as a therapeutic approach. Nat Rev Drug Discov (2002) 1.95
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation. Proc Natl Acad Sci U S A (2007) 1.92
Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception. Proc Natl Acad Sci U S A (2002) 1.88
Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1. J Biol Chem (2004) 1.88
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Common and uncommon pathogenic cascades in lysosomal storage diseases. J Biol Chem (2010) 1.85
Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. Proc Natl Acad Sci U S A (2007) 1.84
NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Am J Physiol Cell Physiol (2006) 1.82
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res (2011) 1.76
Effect of adult strabismus on ratings of official U.S. Army photographs. J AAPOS (2006) 1.74
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J Biol Chem (2010) 1.74
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci U S A (2007) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial. Hepatology (2011) 1.69
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. Biochem J (2011) 1.68
Two-pore channels form homo- and heterodimers. J Biol Chem (2011) 1.67
Storage solutions: treating lysosomal disorders of the brain. Nat Rev Neurosci (2005) 1.65
Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development. J Clin Invest (2008) 1.64
NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells. Curr Biol (2003) 1.62
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis. Proc Natl Acad Sci U S A (2008) 1.59
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. EMBO J (2003) 1.58
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases. J Exp Med (2006) 1.57
Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current. J Physiol (2007) 1.52
A safe lithium mimetic for bipolar disorder. Nat Commun (2013) 1.51
Treatment with miglustat reverses the lipid-trafficking defect in Niemann-Pick disease type C. Neurobiol Dis (2004) 1.50
Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. Clin Chim Acta (2008) 1.50
Sperm express a Ca2+-regulated NAADP synthase. Biochem J (2008) 1.49
Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease. Traffic (2010) 1.49
Feasibility study of noninvasive ventilation with helium-oxygen gas flow for chronic obstructive pulmonary disease during exercise. Respir Care (2009) 1.46
Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism. Circ Res (2002) 1.45
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Germ line determinants are not localized early in sea urchin development, but do accumulate in the small micromere lineage. Dev Biol (2006) 1.43
Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling. Anal Biochem (2004) 1.42
A conserved germline multipotency program. Development (2010) 1.42
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem (2006) 1.39
NAADP controls cross-talk between distinct Ca2+ stores in the heart. J Biol Chem (2007) 1.35
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO J (2002) 1.35
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem (2008) 1.35
Sperm deliver a new second messenger: NAADP. Curr Biol (2003) 1.33
Impact of Acinetobacter infection on the mortality of burn patients. J Am Coll Surg (2006) 1.33
Small micromeres contribute to the germline in the sea urchin. Development (2011) 1.33
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem (2004) 1.32
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci (2009) 1.31
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses. Glycobiology (2005) 1.31
Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol (2006) 1.31
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology (2009) 1.31
Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases. Cell Calcium (2011) 1.30
The oxidative burst at fertilization is dependent upon activation of the dual oxidase Udx1. Dev Cell (2004) 1.29
Nanos functions to maintain the fate of the small micromere lineage in the sea urchin embryo. Dev Biol (2009) 1.29
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg. J Biol Chem (2011) 1.28
Defending the zygote: search for the ancestral animal block to polyspermy. Curr Top Dev Biol (2006) 1.28
Characterization of a human peptide deformylase: implications for antibacterial drug design. Biochemistry (2003) 1.27
A new organotypic culture of thyroid tissue maintains three-dimensional follicles with C cells for a long term. Biochem Biophys Res Commun (2002) 1.27
Calcium signaling via two-pore channels: local or global, that is the question. Am J Physiol Cell Physiol (2009) 1.26