Published in Proc Natl Acad Sci U S A on October 24, 2011
CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol (2014) 1.05
CD4-CD8 differentiation in the thymus: connecting circuits and building memories. Curr Opin Immunol (2012) 0.96
cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J Biol Chem (2013) 0.94
HDAC1 controls CD8+ T cell homeostasis and antiviral response. PLoS One (2014) 0.79
Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming. Nat Commun (2014) 0.78
Transcriptional Enhancers in the Regulation of T Cell Differentiation. Front Immunol (2015) 0.77
In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. PLoS One (2013) 0.77
Transcriptional control of CD4 and CD8 coreceptor expression during T cell development. Cell Mol Life Sci (2013) 0.76
Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo. Immunology (2013) 0.76
What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function. J Immunol (2016) 0.76
Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection. Front Immunol (2016) 0.75
Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. Front Immunol (2017) 0.75
Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis. Br J Haematol (2015) 0.75
[MUW researcher of the month]. Wien Klin Wochenschr (2015) 0.75
Translating the histone code. Science (2001) 56.77
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem (1990) 9.21
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (2004) 2.54
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol (2008) 2.19
Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J (1998) 2.09
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity (2005) 1.91
CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice. Eur J Immunol (2005) 1.56
Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat Rev Immunol (2002) 1.49
An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity (1997) 1.48
Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity (2002) 1.44
Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity (1998) 1.44
Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med (2007) 1.44
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat Immunol (2006) 1.41
Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity (2002) 1.40
Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev (2010) 1.37
A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity (1997) 1.26
T-cell activation in the intestinal mucosa. Immunol Rev (2007) 1.20
Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity. Semin Immunol (2009) 1.15
Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4. J Immunol (2005) 1.15
Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity (1998) 1.13
Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol (2005) 1.09
Transcriptional and epigenetic regulation of CD4/CD8 lineage choice. Adv Immunol (2011) 1.08
Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. J Immunol (2005) 0.90
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity (2004) 3.75
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A (2003) 3.29
Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe (2010) 3.08
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood (2004) 2.90
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol (2007) 2.80
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity (2005) 2.72
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (2004) 2.54
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A (2007) 2.51
RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol (2009) 2.49
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science (2008) 2.43
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39
A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron (2006) 2.26
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell (2008) 2.13
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol (2013) 2.11
Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity (2003) 2.10
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity (2009) 2.05
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood (2005) 1.96
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol (2011) 1.94
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol (2008) 1.89
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity. Nat Immunol (2013) 1.86
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity (2005) 1.85
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol (2004) 1.78
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A (2008) 1.75
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc Natl Acad Sci U S A (2003) 1.69
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A (2006) 1.68
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol (2009) 1.64
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol (2005) 1.57
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol (2008) 1.57
The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells. Proc Natl Acad Sci U S A (2008) 1.54
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol (2003) 1.52
Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat Rev Immunol (2002) 1.49
Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev (2005) 1.46
Runx proteins regulate Foxp3 expression. J Exp Med (2009) 1.45
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat Immunol (2006) 1.41
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39
Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity (2007) 1.33
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol (2010) 1.28
Transcriptional control of T-cell development. Int Immunol (2011) 1.24
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood (2009) 1.23
The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol Lett (2006) 1.23
Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1. J Exp Med (2002) 1.23
The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol (2004) 1.22
CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers. J Biol Chem (2005) 1.18
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J Leukoc Biol (2003) 1.17
Tec regulates platelet activation by GPVI in the absence of Btk. Blood (2003) 1.14
The role of Tec family kinases in the regulation of T-helper-cell differentiation. Int Rev Immunol (2012) 1.12
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J Exp Med (2010) 1.11
Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult. Stem Cells (2007) 1.09
Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol (2005) 1.09
Transcriptional and epigenetic regulation of CD4/CD8 lineage choice. Adv Immunol (2011) 1.08
Critical role of P1-Runx1 in mouse basophil development. Blood (2012) 1.07
The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells. Blood (2012) 1.07
The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood (2008) 1.05
Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis. J Biol Chem (2002) 1.04
Runx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages. J Immunol (2010) 1.03
Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8+ T cell activation. Genes Cells (2002) 1.02
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation. Immunity (2011) 1.02
Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunol (2008) 1.01
The role of Tec family kinases in myeloid cells. Int Arch Allergy Immunol (2004) 1.00
Down-regulation of RXRalpha expression is essential for neutrophil development from granulocyte/monocyte progenitors. Blood (2006) 1.00
Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis. Blood (2010) 0.99
Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis. Diabetes (2011) 0.98
Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement. J Immunol (2008) 0.98
Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells. BMC Genomics (2009) 0.96
The role of Tec family kinases in mononuclear phagocytes. Crit Rev Immunol (2009) 0.95
Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors. J Exp Med (2004) 0.93
Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes. J Immunol (2010) 0.93
Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1. J Exp Med (2012) 0.92
Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol (2008) 0.92
ThPOK derepression is required for robust CD8 T cell responses to viral infection. J Immunol (2009) 0.92
Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells. Biochem Biophys Res Commun (2013) 0.91
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. J Immunol (2010) 0.90
Runx3 deficiency results in myeloproliferative disorder in aged mice. Blood (2013) 0.90
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood (2004) 0.89
Impaired T-cell development in the absence of Vav1 and Itk. Eur J Immunol (2008) 0.89
Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood (2011) 0.88
The protein tyrosine kinase Tec regulates mast cell function. Eur J Immunol (2009) 0.88