Published in Endocrinology on September 01, 2003
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature (2016) 3.61
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04
The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83
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Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
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Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress. J Gerontol A Biol Sci Med Sci (2008) 1.43
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41
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Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. J Gerontol A Biol Sci Med Sci (2009) 1.36
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Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J (2010) 1.33
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
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Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc Natl Acad Sci U S A (2010) 1.21
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RasGrf1 deficiency delays aging in mice. Aging (Albany NY) (2011) 1.16
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Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY) (2014) 1.15
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Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
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The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10
The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2009) 1.10
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Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene. J Clin Endocrinol Metab (2009) 1.09
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Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans? J Gerontol A Biol Sci Med Sci (2009) 1.09
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS One (2011) 1.07
Hormonal control of aging in rodents: the somatotropic axis. Mol Cell Endocrinol (2008) 1.07
Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype. J Endocrinol (2008) 1.06
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging Cell (2009) 1.06
Metabolic characteristics of long-lived mice. Front Genet (2012) 1.04
Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology (2009) 1.04
The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell (2010) 1.03
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02
Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development. PLoS One (2010) 1.02
Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res (2011) 1.00
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99
The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One (2012) 0.98
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Aging and dry eye disease. Exp Gerontol (2012) 0.97
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. Elife (2013) 0.97
Discovery of functional gene variants associated with human longevity: opportunities and challenges. J Gerontol A Biol Sci Med Sci (2011) 0.96
Growth hormone, inflammation and aging. Pathobiol Aging Age Relat Dis (2012) 0.96
Gene expression defines natural changes in mammalian lifespan. Aging Cell (2015) 0.96
Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens. BMC Genomics (2012) 0.95
The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res (2007) 0.95
Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions. J Gerontol A Biol Sci Med Sci (2011) 0.95
CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis. Comp Hepatol (2007) 0.95
A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis. J Clin Invest (2012) 0.94
Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice. Int J Biol Sci (2010) 0.94
Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice. Mech Ageing Dev (2009) 0.93
Novel roles for JNK1 in metabolism. Aging (Albany NY) (2010) 0.92
Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?--a pathological point of view. Age (Dordr) (2006) 0.92
Sex- and age-specific differences in core body temperature of C57Bl/6 mice. Age (Dordr) (2010) 0.92
NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction. J Clin Exp Pathol (2012) 0.92
Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation. Aging Cell (2013) 0.91
Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. J Physiol (2010) 0.91
Plasma biomarkers of mouse aging. Age (Dordr) (2010) 0.90
Public and private mechanisms of life extension in Caenorhabditis elegans. Mol Genet Genomics (2007) 0.89
Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordr) (2009) 0.89
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. Cell Metab (2015) 0.88
Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends Neurosci (2014) 0.88
Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini. Endocrinology (2013) 0.87
Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency. Growth Horm IGF Res (2009) 0.87
Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research. Cell Cycle (2014) 0.87
Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock. Exp Gerontol (2005) 0.86
Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol (2014) 0.86
Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice. Cell Biochem Funct (2011) 0.86
The effects of physiological adaptations to calorie restriction on global cell proliferation rates. Am J Physiol Endocrinol Metab (2011) 0.86
In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene. Exp Gerontol (2010) 0.85
Decreased expression level of apoptosis-related genes and/or proteins in skeletal muscles, but not in hearts, of growth hormone receptor knockout mice. Exp Biol Med (Maywood) (2011) 0.85
Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice. J Gerontol A Biol Sci Med Sci (2013) 0.84
Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice. Oncotarget (2015) 0.84
Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet. Endocrinology (2014) 0.84
Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension. Age (Dordr) (2011) 0.84
Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics (2014) 0.84
The somatotropic axis and aging: mechanisms and persistent questions about practical implications. Exp Gerontol (2009) 0.84
Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction. PLoS One (2013) 0.84
Adult height, dietary patterns, and healthy aging. Am J Clin Nutr (2017) 0.84
Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice. Endocrinology (2016) 0.83
Prevention and early detection of vascular complications of diabetes. BMJ (2006) 4.14
Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy. Kidney Int (2008) 3.27
Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation (2005) 2.81
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol (2005) 2.75
Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol Metab (2006) 2.52
The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int (2004) 2.42
Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology (2009) 2.39
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res (2004) 1.96
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2004) 1.92
Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion. Am J Physiol Endocrinol Metab (2010) 1.82
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest (2004) 1.82
From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines. Endocr Rev (2004) 1.74
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes (2005) 1.71
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes (2002) 1.69
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. Eur Heart J (2007) 1.63
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc Natl Acad Sci U S A (2010) 1.62
Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61
Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. Am J Hypertens (2009) 1.61
Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men. J Clin Endocrinol Metab (2006) 1.61
Adiponectin and lipoprotein particle size. Diabetes Care (2009) 1.60
Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetes (2004) 1.59
The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care (2006) 1.52
Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung. J Clin Endocrinol Metab (2007) 1.49
Osteoprotegerin and cardiovascular mortality in patients with non-ST elevation acute coronary syndromes. Heart (2012) 1.47
Osteoprotegerin predicts long-term outcome in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Cardiology (2012) 1.44
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Reversal of experimental Laron Syndrome by xenotransplantation of microencapsulated porcine Sertoli cells. J Control Release (2012) 1.40
Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds. Biomaterials (2006) 1.38
Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes (2007) 1.36
Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. J Physiol (2009) 1.36
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Serum adiponectin is increased in type 1 diabetic patients with nephropathy. Diabetes Care (2005) 1.35
Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients. Eur J Endocrinol (2006) 1.34
Assessment of early diabetic renal changes with hyperpolarized [1-(13) C]pyruvate. Diabetes Metab Res Rev (2013) 1.34
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Cardiovascular disease and insulin-like growth factor I. Circulation (2002) 1.30
Differentially expressed proteins in the pancreas of diet-induced diabetic mice. Mol Cell Proteomics (2005) 1.28
Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study. Diabetes (2012) 1.27
Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids (2002) 1.25
Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology (2008) 1.25
Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial. J Hepatol (2005) 1.23
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun (2005) 1.20
Effect of growth hormone on susceptibility to diet-induced obesity. Endocrinology (2006) 1.18
Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naive compared with patients with osteoarthritis and controls. J Rheumatol (2009) 1.18
Prognostic utility of neutrophil gelatinase-associated lipocalin in predicting mortality and cardiovascular events in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol (2012) 1.17
Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology (2007) 1.16
Ghrelin and its relationship to growth hormones during normal pregnancy. Clin Endocrinol (Oxf) (2005) 1.15
Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women. J Appl Physiol (1985) (2008) 1.13
Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models. J Bone Miner Res (2010) 1.13
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc Natl Acad Sci U S A (2006) 1.12
Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. J Clin Endocrinol Metab (2007) 1.12
Elevated levels of high-molecular-weight adiponectin in type 1 diabetes. J Clin Endocrinol Metab (2008) 1.12
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
Prognostic value of circulating chromogranin A levels in acute coronary syndromes. Eur Heart J (2008) 1.11
Development of pure prolactin receptor antagonists. J Biol Chem (2003) 1.11
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10
Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study. Diabetes (2005) 1.10
Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin. Crit Care (2009) 1.10
The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat Rev Endocrinol (2013) 1.09
Mannose-binding lectin and mortality in type 2 diabetes. Arch Intern Med (2006) 1.09
The role of prolactin and growth hormone in mammary gland development. Mol Cell Endocrinol (2002) 1.09
Serum insulin-like growth factors, insulin-like growth factor binding proteins, and breast cancer risk in postmenopausal women. Cancer Epidemiol Biomarkers Prev (2004) 1.06
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab (2005) 1.06
Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty. J Bone Miner Res (2007) 1.06
Complement activation and diabetic vascular complications. Clin Chim Acta (2005) 1.06
Fatty liver index, gamma-glutamyltransferase, and early carotid plaques. Hepatology (2012) 1.05
Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes. Diabetes Care (2008) 1.04
Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial. Am Heart J (2010) 1.04
Plasma adiponectin levels in relation to carotid intima media thickness and markers of insulin resistance. Arterioscler Thromb Vasc Biol (2006) 1.03
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02
Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon. J Appl Physiol (1985) (2006) 1.01
Growth hormone is required for ovarian follicular growth. Endocrinology (2002) 1.01
Analysis of mouse skin reveals proteins that are altered in a diet-induced diabetic state: a new method for detection of type 2 diabetes. Proteomics (2007) 1.01
Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors. Am J Physiol Endocrinol Metab (2007) 1.01
Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice. Exp Biol Med (Maywood) (2003) 1.01
Sex-discordant associations with adiponectin levels and lipid profiles in children. Diabetes (2006) 1.00
Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.00
Heterogeneity among white adipose tissue depots in male C57BL/6J mice. Obesity (Silver Spring) (2011) 1.00
Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res (2011) 1.00
Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity. J Pharmacol Exp Ther (2011) 0.99
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99
Serum adiponectin in elderly men does not correlate with fracture risk. J Clin Endocrinol Metab (2008) 0.99
The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women. Am J Hypertens (2009) 0.98
Acute growth hormone administration causes exaggerated increases in plasma lactate and glycerol during moderate to high intensity bicycling in trained young men. J Clin Endocrinol Metab (2002) 0.98
Elevated circulating adiponectin in type 1 diabetes is associated with long diabetes duration. Clin Endocrinol (Oxf) (2006) 0.98