Growth hormone, inflammation and aging.

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY) (2014) 1.15

Metabolic characteristics of long-lived mice. Front Genet (2012) 1.04

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism. EMBO Mol Med (2013) 1.01

Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. Aging Cell (2015) 0.91

Obesity and related consequences to ageing. Age (Dordr) (2016) 0.83

The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice. Aging (Albany NY) (2014) 0.82

Insulin sensitivity in long-living Ames dwarf mice. Age (Dordr) (2014) 0.81

Elevated systolic blood pressure in male GH transgenic mice is age dependent. Endocrinology (2013) 0.81

Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse. Aging Cell (2015) 0.81

Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep (2014) 0.80

Healthspan and longevity can be extended by suppression of growth hormone signaling. Mamm Genome (2016) 0.77

Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice. Mol Cell Endocrinol (2016) 0.76

Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes. Aging (Albany NY) (2016) 0.76

In case of obesity, longevity-related mechanisms lead to anti-inflammation. Age (Dordr) (2013) 0.75

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxid Med Cell Longev (2016) 0.75

Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats. Iran J Basic Med Sci (2017) 0.75

Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen. Blood Cells Mol Dis (2015) 0.75

The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover study. J Int Soc Sports Nutr (2013) 0.75

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Adipose tissue as an endocrine organ. J Clin Endocrinol Metab (2004) 11.94

Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77

Demography. Broken limits to life expectancy. Science (2002) 10.65

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab (2001) 9.53

Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol (2005) 8.39

Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci (2000) 8.26

Inflammatory exposure and historical changes in human life-spans. Science (2004) 7.41

Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw (2006) 7.19

Dwarf mice and the ageing process. Nature (1996) 6.12

Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14

Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev (2009) 4.35

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A (2001) 4.30

Inflammation as a cardiovascular risk factor. Circulation (2004) 4.26

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology (2003) 3.59

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A (1997) 3.42

Infection, inflammation, height, and longevity. Proc Natl Acad Sci U S A (2005) 3.17

Aging and proinflammatory cytokines. Curr Opin Hematol (2001) 3.05

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett (2005) 2.30

A role for preadipocytes as macrophage-like cells. FASEB J (1999) 2.24

Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology (2004) 1.90

Human growth hormone and human aging. Endocr Rev (1993) 1.80

Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67

Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology (2003) 1.53

Hormones and the immunological capacity. IV. Restorative effects of developmental hormones or of lymphocytes on the immunodeficiency syndrome of the dwarf mouse. Clin Exp Immunol (1971) 1.49

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev (1997) 1.47

Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. J Gerontol A Biol Sci Med Sci (2006) 1.35

Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines. Am J Cardiol (2003) 1.34

Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32

Inflammation, heat shock proteins, and type 2 diabetes. Cell Stress Chaperones (2008) 1.25

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology (2007) 1.23

Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J Gerontol A Biol Sci Med Sci (2006) 1.16

Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone (GH) deficiency due to a GH-releasing hormone receptor mutation. J Clin Endocrinol Metab (2006) 1.15

Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo. J Immunol (1992) 1.14

The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2009) 1.10

The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev (1997) 1.09

Aging and hormones of the hypothalamo-pituitary axis: gonadotropic axis in men and somatotropic axes in men and women. Ageing Res Rev (2008) 1.06

Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2010) 0.97

Immunologic disparity in the hypopituitary dwarf mouse. J Immunol (1992) 0.96

Influence of caloric restriction on aging immune system. J Nutr Health Aging (2004) 0.95

Defective B cell development in Snell dwarf (dw/dw) mice can be corrected by thyroxine treatment. J Immunol (1996) 0.95

Immunodeficiency of the thymus-dependent system of the Ames dwarf mouse. J Immunol (1972) 0.94

Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats. J Clin Immunol (1997) 0.90

Caloric restriction and immunosenescence: a current perspective. Front Biosci (2000) 0.88

Effects of hormones on development and function of lymphoid tissues. Synergistic action of thyroxin and somatotropic hormone in pituitary dwarf mice. Immunology (1969) 0.88

Ectopic pituitary transplants restore immunocompetence in Ames dwarf mice. Acta Endocrinol (Copenh) (1991) 0.86

Adipose tissue changes in obesity. Biochem Soc Trans (2005) 0.85

Immunological competence in Snell-Bagg pituitary dwarf mice: response to the contact-sensitizing agent oxazolone. Am J Anat (1976) 0.84

Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation. Exp Gerontol (2007) 0.84

Recombinant human growth hormone improves survival and protects against acute lung injury in murine Staphylococcus aureus sepsis. Inflamm Res (2009) 0.84

T and B lymphocytes in pituitary dwarf Snell-Bagg mice. Immunology (1979) 0.83

Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells. Proc Soc Exp Biol Med (2000) 0.83

Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice. Growth Horm IGF Res (2010) 0.83

Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes. Endocrinology (2010) 0.81

The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency. Growth Horm IGF Res (2010) 0.81

Involvement of sensory nerves in the protective effect of growth hormone on acute pancreatitis. Growth Horm IGF Res (2009) 0.80

Adiponectin is required for enhancement of CCL2 expression in adipose tissue during Listeria monocytogenes infection. Cytokine (2009) 0.78

The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab (2005) 2.59

Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2005) 2.28

The critical role of metabolic pathways in aging. Diabetes (2012) 2.12

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08

Diet and aging. Cell Metab (2008) 2.05

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology (2004) 1.90

Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76

Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65

Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61

Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab (2013) 1.61

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol (2008) 1.55

Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell (2006) 1.54

Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics (2004) 1.50

Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging (2005) 1.49

Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42

Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci (2009) 1.42

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41

Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. J Gerontol A Biol Sci Med Sci (2009) 1.36

Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev (2006) 1.36

Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. J Gerontol A Biol Sci Med Sci (2006) 1.35

Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J (2010) 1.33

Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32

Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.25

MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. Aging Cell (2009) 1.24

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp Gerontol (2005) 1.23

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology (2007) 1.23

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab (2012) 1.23

Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Exp Eye Res (2005) 1.20

GH and IGF1: roles in energy metabolism of long-living GH mutant mice. J Gerontol A Biol Sci Med Sci (2012) 1.20

A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner? Aging (Albany NY) (2010) 1.18

Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J Gerontol A Biol Sci Med Sci (2006) 1.16

PPARs in Calorie Restricted and Genetically Long-Lived Mice. PPAR Res (2007) 1.16

Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13

Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol (2002) 1.11

The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11

The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10

Divergent effects of caloric restriction on gene expression in normal and long-lived mice. J Gerontol A Biol Sci Med Sci (2004) 1.10

Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans? J Gerontol A Biol Sci Med Sci (2009) 1.09

Rapamycin slows aging in mice. Cell Cycle (2012) 1.08

The consequences of altered somatotropic system on reproduction. Biol Reprod (2004) 1.08

The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging Cell (2009) 1.06

Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med (2009) 1.04

Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide. Physiol Behav (2003) 1.04

What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03

Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology (2004) 1.02

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02

Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice. Biol Reprod (2002) 1.01

Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance. Exp Gerontol (2008) 1.00

Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.00

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99

The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging Cell (2014) 0.98

Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2010) 0.97

Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle. J Gerontol A Biol Sci Med Sci (2007) 0.97

Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice. Exp Gerontol (2005) 0.97

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. Elife (2013) 0.97

Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions. J Gerontol A Biol Sci Med Sci (2011) 0.95

Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice. Endocrinology (2007) 0.95

Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice. Endocrine (2003) 0.94

Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice. Int J Biol Sci (2010) 0.94

C-reactive protein and glucose regulation in familial longevity. Age (Dordr) (2011) 0.93

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice. Mech Ageing Dev (2009) 0.93

Puberty is delayed in male growth hormone receptor gene-disrupted mice. J Androl (2002) 0.93

Adult neurogenesis in the hippocampus of long-lived mice during aging. J Gerontol A Biol Sci Med Sci (2007) 0.93

Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice. Aging Cell (2011) 0.92

Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction. J Gerontol A Biol Sci Med Sci (2008) 0.91

The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver. Mech Ageing Dev (2003) 0.90

Prolonged rapamycin treatment led to beneficial metabolic switch. Aging (Albany NY) (2013) 0.90

Effects of long-term caloric restriction on early steps of the insulin-signaling system in mouse skeletal muscle. J Gerontol A Biol Sci Med Sci (2005) 0.90

Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain. J Am Aging Assoc (2002) 0.89

Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89

Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice. Exp Gerontol (2005) 0.89

Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis. Biol Chem (2010) 0.89

Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1. J Ovarian Res (2012) 0.89

Dietary restriction and life-span. Science (2002) 0.87

Transgenic mice overexpressing GH exhibit hepatic upregulation of GH-signaling mediators involved in cell proliferation. J Endocrinol (2008) 0.86

Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice. Cell Biochem Funct (2011) 0.86

Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS One (2012) 0.86

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone. Cell Cycle (2013) 0.85

Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis. Mech Ageing Dev (2007) 0.85

Decreased expression level of apoptosis-related genes and/or proteins in skeletal muscles, but not in hearts, of growth hormone receptor knockout mice. Exp Biol Med (Maywood) (2011) 0.85

In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene. Exp Gerontol (2010) 0.85

RasGrf1: genomic imprinting, VSELs, and aging. Aging (Albany NY) (2011) 0.85

Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction. PLoS One (2013) 0.84

Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation. Exp Gerontol (2007) 0.84

Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension. Age (Dordr) (2011) 0.84

IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell (2014) 0.84

Parting messages from current and former editors of the Journal of Andrology. J Androl (2012) 0.83

Suppression of growth hormone (GH) Janus tyrosine kinase 2/signal transducer and activator of transcription 5 signaling pathway in transgenic mice overexpressing bovine GH. Endocrinology (2004) 0.83

Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2012) 0.83

Insulin resistance and cognitive aging in long-lived and short-lived mice. J Gerontol A Biol Sci Med Sci (2005) 0.83

GH modulates hepatic epidermal growth factor signaling in the mouse. J Endocrinol (2009) 0.82

Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. Am J Physiol Endocrinol Metab (2013) 0.82

Soy isoflavones modify liver free radical scavenger systems and liver parameters in Sprague-Dawley rats. J Med Food (2004) 0.81

Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal. Biol Chem (2011) 0.81