Published in Growth Horm IGF Res on August 01, 2004
Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34
Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol (2008) 2.35
Fasting levels of high-sensitivity growth hormone predict cardiovascular morbidity and mortality: the Malmö Diet and Cancer study. J Am Coll Cardiol (2014) 2.16
Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci (2010) 1.82
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
The GH/IGF-1 axis in ageing and longevity. Nat Rev Endocrinol (2013) 1.68
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci (2009) 1.42
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res (2009) 1.35
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology (2008) 1.25
Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev (2013) 1.22
GH and IGF1: roles in energy metabolism of long-living GH mutant mice. J Gerontol A Biol Sci Med Sci (2012) 1.20
PPARs in Calorie Restricted and Genetically Long-Lived Mice. PPAR Res (2007) 1.16
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY) (2014) 1.15
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat Rev Endocrinol (2013) 1.09
Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans? J Gerontol A Biol Sci Med Sci (2009) 1.09
Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol (2007) 1.07
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02
Peptides and food intake. Front Endocrinol (Lausanne) (2014) 1.01
Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res (2011) 1.00
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99
IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects. Endocrinology (2010) 0.99
Growth hormone and aging: a challenging controversy. Clin Interv Aging (2008) 0.98
Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. Endocrinology (2011) 0.96
Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS One (2008) 0.95
Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice. Exp Gerontol (2008) 0.93
Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?--a pathological point of view. Age (Dordr) (2006) 0.92
The intricate role of growth hormone in metabolism. Front Endocrinol (Lausanne) (2011) 0.89
Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1. J Ovarian Res (2012) 0.89
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. Int J Pept (2010) 0.88
Plasma proteomic profiles of bovine growth hormone transgenic mice as they age. Transgenic Res (2011) 0.88
Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini. Endocrinology (2013) 0.87
Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency. Growth Horm IGF Res (2009) 0.87
Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice. Oncotarget (2015) 0.84
Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension. Age (Dordr) (2011) 0.84
Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet. Endocrinology (2014) 0.84
A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age. J Gerontol A Biol Sci Med Sci (2013) 0.83
Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice. Growth Horm IGF Res (2010) 0.83
The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice. Oncotarget (2015) 0.83
Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications. Mol Cell Endocrinol (2013) 0.83
Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2012) 0.83
Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Endocrinology (2014) 0.82
Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency? Am J Physiol Endocrinol Metab (2008) 0.82
Links between growth hormone and aging. Endokrynol Pol (2013) 0.82
Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation. PLoS One (2012) 0.82
Mouse models of growth hormone action and aging: a proteomic perspective. Proteomics (2012) 0.82
Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2011) 0.81
Elevated systolic blood pressure in male GH transgenic mice is age dependent. Endocrinology (2013) 0.81
The modulation of adiponectin by STAT5-activating hormones. Am J Physiol Endocrinol Metab (2015) 0.80
Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure. Aging Cell (2016) 0.80
Metabolic alterations due to caloric restriction and every other day feeding in normal and growth hormone receptor knockout mice. J Gerontol A Biol Sci Med Sci (2013) 0.80
Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice. Growth Horm IGF Res (2012) 0.79
GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells. J Endocrinol (2015) 0.79
Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age. Age (Dordr) (2014) 0.79
Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice. Age (Dordr) (2006) 0.79
MAP dendrimer elicits antibodies for detecting rat and mouse GH-binding proteins. J Pept Sci (2009) 0.78
Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure. Matrix Biol (2013) 0.78
Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent. J Gerontol A Biol Sci Med Sci (2014) 0.78
The somatotropic axis and aging: Benefits of endocrine defects. Growth Horm IGF Res (2016) 0.78
Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. Aging Cell (2014) 0.77
Healthspan and longevity can be extended by suppression of growth hormone signaling. Mamm Genome (2016) 0.77
Selective inner retinal dysfunction in growth hormone transgenic mice. Growth Horm IGF Res (2011) 0.77
Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism. PLoS One (2014) 0.77
Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence. Gerontology (2015) 0.76
Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model. J Gerontol A Biol Sci Med Sci (2013) 0.76
Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength. Endocrinology (2015) 0.75
Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice. Int J Endocrinol (2015) 0.75
Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic. Expert Rev Endocrinol Metab (2016) 0.75
Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence? Aging Cell (2015) 0.75
The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity. Biochem Insights (2017) 0.75
Repression of GH signaling: one extended life to live! Aging (Albany NY) (2013) 0.75
Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland. J Ophthalmol (2016) 0.75
Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease. PLoS One (2017) 0.75
Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1. Folia Histochem Cytobiol (2015) 0.75
Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. Worm (2016) 0.75
Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations. Adipocyte (2017) 0.75
Sex differences in lifespan extension with acarbose and 17-α estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell (2017) 0.75
Insulin, IGF-1, and GH Receptors are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice with Modified GH Action. Endocrinology (2017) 0.75
Growth Hormone's Effect on Adipose Tissue: Quality versus Quantity. Int J Mol Sci (2017) 0.75
The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies. Clin Proteomics (2017) 0.75
Endocrine regulation of energy metabolism by the skeleton. Cell (2007) 10.41
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes (2008) 5.62
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes (2004) 4.37
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology (2003) 3.59
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest (2009) 2.46
Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A (2008) 2.41
Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes (2005) 2.33
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 2.20
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2004) 1.92
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest (2004) 1.91
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest (2007) 1.91
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes (2008) 1.88
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest (2004) 1.82
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab (2006) 1.76
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest (2009) 1.73
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem (2009) 1.71
Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab (2007) 1.71
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J Neurosci (2002) 1.69
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods (2012) 1.67
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes (2009) 1.67
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol (2007) 1.66
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc Natl Acad Sci U S A (2010) 1.62
Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell (2003) 1.60
Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes (2006) 1.56
Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. Am J Physiol Endocrinol Metab (2007) 1.55
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab (2009) 1.53
The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci (2008) 1.49
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol (2010) 1.42
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med (2006) 1.42
Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes (2008) 1.41
Reversal of experimental Laron Syndrome by xenotransplantation of microencapsulated porcine Sertoli cells. J Control Release (2012) 1.40
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 1.36
Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes (2007) 1.36
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem (2004) 1.34
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes (2005) 1.33
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle. Am J Physiol Cell Physiol (2005) 1.29
Differentially expressed proteins in the pancreas of diet-induced diabetic mice. Mol Cell Proteomics (2005) 1.28
Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids (2002) 1.25
Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology (2008) 1.25
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem (2004) 1.25
Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes (2008) 1.25
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A (2007) 1.25
Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab (2007) 1.23
Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol (2010) 1.23
Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes (2009) 1.23
Effects of chronic Akt activation on glucose uptake in the heart. Am J Physiol Endocrinol Metab (2005) 1.22
Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res (2010) 1.21
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun (2005) 1.20
The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. J Immunol (2007) 1.18
Effect of growth hormone on susceptibility to diet-induced obesity. Endocrinology (2006) 1.18
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Am J Physiol Endocrinol Metab (2005) 1.17
Insulin resistance in tetracycline-repressible Munc18c transgenic mice. Diabetes (2003) 1.17
Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1. Am J Physiol Endocrinol Metab (2006) 1.16
Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models. J Bone Miner Res (2010) 1.13
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci (2009) 1.13
Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc Natl Acad Sci U S A (2006) 1.12
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest (2014) 1.12
Development of pure prolactin receptor antagonists. J Biol Chem (2003) 1.11
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10
Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. Diabetes (2002) 1.10
Syntaxin 4 transgenic mice exhibit enhanced insulin-mediated glucose uptake in skeletal muscle. Diabetes (2004) 1.10
The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat Rev Endocrinol (2013) 1.09
Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. Aging Cell (2012) 1.09
The role of prolactin and growth hormone in mammary gland development. Mol Cell Endocrinol (2002) 1.09
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Am J Physiol Endocrinol Metab (2007) 1.07
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab (2005) 1.06
Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty. J Bone Miner Res (2007) 1.06
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes (2011) 1.06
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab (2010) 1.04
Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet (2012) 1.03
New insights into insulin resistance in the diabetic heart. Trends Endocrinol Metab (2011) 1.03
Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab (2012) 1.02
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02