Published in Mol Genet Genomics on March 16, 2007
Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol (2008) 2.49
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75
Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) (2011) 1.28
Nonhuman primate calorie restriction. Antioxid Redox Signal (2010) 1.11
Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q. Aging Cell (2008) 1.06
Developmental biomarkers of aging in Caenorhabditis elegans. Dev Dyn (2010) 1.02
Caloric restriction improves health and survival of rhesus monkeys. Nat Commun (2017) 0.90
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet (2010) 0.85
Transcriptional (dys)regulation and aging in Caenorhabditis elegans. Genome Biol (2008) 0.79
The SKN-1 hunger games: May the odds be ever in your favor. Worm (2015) 0.75
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature (2003) 14.49
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature (1997) 13.09
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (1997) 11.60
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36
The plasticity of aging: insights from long-lived mutants. Cell (2005) 9.88
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Extrachromosomal rDNA circles--a cause of aging in yeast. Cell (1997) 8.68
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Why do we age? Nature (2000) 8.48
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48
Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (2003) 8.43
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature (2002) 8.35
The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science (2001) 8.06
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85
Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 7.21
The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Dev Biol (1975) 7.20
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet (2001) 6.45
Signals from the reproductive system regulate the lifespan of C. elegans. Nature (1999) 6.41
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature (1996) 6.32
Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26
Dwarf mice and the ageing process. Nature (1996) 6.12
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol (2001) 5.81
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev (1998) 5.77
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics (1988) 5.60
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell (2003) 5.39
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics (1998) 5.37
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A (2005) 5.34
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J (2000) 5.30
Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development (2004) 5.27
Interacting genes in nematode dauer larva formation. Nature (1981) 5.21
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A (1995) 5.18
Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics (1995) 5.09
Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem (2003) 5.04
Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev (1978) 5.03
Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature (1999) 4.91
Mechanism of human SIRT1 activation by resveratrol. J Biol Chem (2005) 4.86
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev (2004) 4.84
Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science (2000) 4.72
Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (2004) 4.70
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol (2003) 4.67
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell (2003) 4.63
The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Dev Biol (1984) 4.62
DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell (2001) 4.49
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J (1999) 4.46
A developmental timing microRNA and its target regulate life span in C. elegans. Science (2005) 4.24
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet (2005) 4.15
AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays (2001) 4.07
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics (1992) 4.04
Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans. Genetics (1993) 3.99
Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone. Nature (2005) 3.97
Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1993) 3.97
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
Mortality rates in a genetically heterogeneous population of Caenorhabditis elegans. Science (1994) 3.92
A pheromone influences larval development in the nematode Caenorhabditis elegans. Science (1982) 3.88
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell (2006) 3.82
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol (2001) 3.75
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology (2003) 3.59
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev (2001) 3.59
Determination of life-span in Caenorhabditis elegans by four clock genes. Science (1996) 3.58
Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron (2004) 3.56
Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J Biol Chem (2004) 3.52
Extension of life-span with superoxide dismutase/catalase mimetics. Science (2000) 3.41
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39
A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A (1984) 3.39
Global analysis of dauer gene expression in Caenorhabditis elegans. Development (2003) 3.38
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell (2003) 3.34
A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev (1983) 3.34
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics (1995) 3.33
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science (1997) 3.30
A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet (2005) 3.29
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev (2003) 3.22
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell (1998) 3.21
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev (1999) 3.21
Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 3.20
Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J (2002) 3.13
Non-ageing developmental variant of Caenorhabditis elegans. Nature (1976) 3.09
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell (2004) 3.08
An improved molecular phylogeny of the Nematoda with special emphasis on marine taxa. Mol Phylogenet Evol (2006) 3.38
Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans. BMC Mol Biol (2008) 2.73
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev (2008) 2.71
Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp Gerontol (2003) 2.39
Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans. Exp Gerontol (2002) 1.94
Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech Ageing Dev (2005) 1.75
A phylogenomic profile of globins. BMC Evol Biol (2006) 1.64
Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C. elegans. Exp Gerontol (2002) 1.64
Assaying metabolic activity in ageing Caenorhabditis elegans. Mech Ageing Dev (2002) 1.53
Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans. Exp Gerontol (2005) 1.50
DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO. Mol Syst Biol (2010) 1.48
No reduction of metabolic rate in food restricted Caenorhabditis elegans. Exp Gerontol (2002) 1.26
Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family. BMC Genomics (2007) 1.26
A model of globin evolution. Gene (2007) 1.22
Three globin lineages belonging to two structural classes in genomes from the three kingdoms of life. Proc Natl Acad Sci U S A (2005) 1.22
Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans. Exp Gerontol (2007) 1.13
Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans. Free Radic Biol Med (2011) 1.13
Molecular phylogeny of the Tylenchina and evolution of the female gonoduct (Nematoda: Rhabditida). Mol Phylogenet Evol (2008) 1.10
No reduction of energy metabolism in Clk mutants. Mech Ageing Dev (2002) 1.07
The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification. BMC Evol Biol (2008) 1.06
Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans. BMC Biol (2010) 1.02
Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans. Aging Cell (2005) 1.01
DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism. Neurobiol Aging (2005) 1.01
Dietary restriction in the nematode Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci (2005) 1.00
Dietary restriction in the nematode Caenorhabditis elegans. Interdiscip Top Gerontol (2007) 0.96
Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans. Exp Gerontol (2010) 0.94
Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbes. J Gerontol A Biol Sci Med Sci (2008) 0.94
Genetic control of longevity in C. elegans. Exp Gerontol (2006) 0.94
Phylogenetic analysis of anostracans (Branchiopoda: Anostraca) inferred from nuclear 18S ribosomal DNA (18S rDNA) sequences. Mol Phylogenet Evol (2002) 0.93
Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies. Aging Cell (2002) 0.90
Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells. Free Radic Biol Med (2008) 0.90
Intermediary metabolism. WormBook (2009) 0.90
The longevity effect of dietary restriction in Caenorhabditis elegans. Exp Gerontol (2006) 0.88
Phylogenetic relationships, divergence time estimation, and global biogeographic patterns of calopterygoid damselflies (odonata, zygoptera) inferred from ribosomal DNA sequences. Syst Biol (2005) 0.87
Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Biotechnol J (2008) 0.85
Extending life-span in C. elegans. Science (2004) 0.84
Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the aging model Podospora anserina. PLoS One (2011) 0.83
Protein metabolism and lifespan in Caenorhabditis elegans. Adv Exp Med Biol (2010) 0.81
The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human? Biogerontology (2006) 0.81
The hunt for the record life span in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci (2004) 0.80
A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria. Anal Biochem (2012) 0.80
The nerve hemoglobin of the bivalve mollusc Spisula solidissima: molecular cloning, ligand binding studies, and phylogenetic analysis. J Biol Chem (2005) 0.78
Globins in Caenorhabditis elegans. IUBMB Life (2011) 0.78
Rebuttal to Van Voorhies: 'the influence of metabolic rate on longevity in the nematode Caenorhabditis elegans'. Aging Cell (2002) 0.76