Published in Mol Cell Biol on September 01, 2003
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A (2006) 2.92
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15
The Notch pathway in ovarian carcinomas and adenomas. Br J Cancer (2005) 1.54
Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem (2010) 1.38
Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol (2007) 1.36
Aging of signal transduction pathways, and pathology. Exp Cell Res (2008) 1.16
The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity. Mol Cell Biol (2008) 0.94
Requirement of a dynein light chain in transforming growth factor β signaling in zebrafish ovarian follicle cells. Mol Cell Endocrinol (2011) 0.77
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 10.06
How cells read TGF-beta signals. Nat Rev Mol Cell Biol (2000) 8.93
Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity (1999) 8.33
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature (1996) 8.02
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Notch signaling: from the outside in. Dev Biol (2000) 6.06
Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet (1997) 5.58
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med (1996) 4.79
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A (1995) 4.54
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol (1996) 4.26
Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med (2002) 4.04
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol (2001) 3.69
Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A (1995) 3.33
Expression cloning and characterization of the TGF-beta type III receptor. Cell (1991) 2.89
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol (2001) 2.74
Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev (1992) 2.59
Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci U S A (2001) 2.55
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol (1997) 2.48
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J (2000) 2.41
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J (2000) 2.41
Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron (2001) 2.32
Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science (1996) 2.31
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes Dev (1996) 2.18
Concern Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B). Mol Cell (2002) 2.09
Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science (2001) 1.97
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet (1998) 1.96
Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev Biol (1998) 1.90
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev (2000) 1.87
The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2. J Virol (1999) 1.81
c-myc is a downstream target of the Smad pathway. J Biol Chem (2001) 1.74
Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene (2002) 1.67
Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway. Mol Cell Biol (1999) 1.57
Notch signaling: a dance of proteins changing partners. Exp Cell Res (2000) 1.55
The notch intracellular domain can function as a coactivator for LEF-1. Mol Cell Biol (2001) 1.45
Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J Virol (1996) 1.30
An invitation to T and more: notch signaling in lymphopoiesis. Cell (2002) 1.26
Notch and wingless regulate expression of cuticle patterning genes. Mol Cell Biol (1999) 1.13
Interactions between Wingless and Notch during the assignment of cell fates in Drosophila. Int J Dev Biol (1998) 0.90
Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol Cell Biol (2004) 1.55
Inhibition of myogenesis by Notch: evidence for multiple pathways. J Cell Physiol (2009) 1.28
Consequences of Notch-mediated induction of Jagged1. Exp Cell Res (2004) 1.23
Functional analysis of Hes-1 in preadipocytes. Mol Endocrinol (2005) 1.21
The Notch effector Hey1 associates with myogenic target genes to repress myogenesis. J Biol Chem (2009) 1.11
Notch and Schwann cell transformation. Oncogene (2004) 1.08
Regulation of skeletal myogenesis by Notch. Exp Cell Res (2010) 1.08
Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. Blood (2005) 0.99
Inhibition of p300/CBP by early B-cell factor. Mol Cell Biol (2003) 0.94