Published in Radiat Oncol on January 19, 2017
Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting : Current and Future Application of Intraoperative Radiotherapy (IORT) in the Curative and Palliative Treatment of Breast Cancer. Ann Surg Oncol (2017) 0.75
Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection. Front Oncol (2017) 0.75
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science (2001) 7.13
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A (2003) 6.82
Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol (2003) 6.36
Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy. Int J Radiat Oncol Biol Phys (2008) 5.03
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J Clin Oncol (2003) 4.73
Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol (2013) 4.21
The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol (2013) 4.00
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (2010) 3.56
Radiation dose-volume effects in the brain. Int J Radiat Oncol Biol Phys (2010) 2.94
Radiation and ceramide-induced apoptosis. Oncogene (2003) 2.68
No significant endothelial apoptosis in the radiation-induced gastrointestinal syndrome. Int J Radiat Oncol Biol Phys (2007) 2.68
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65
Local recurrences and distant metastases after conservative breast cancer treatments: partly independent events. J Natl Cancer Inst (1995) 2.52
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
The relationship between waiting time for radiotherapy and clinical outcomes: a systematic review of the literature. Radiother Oncol (2007) 2.40
Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. Int J Radiat Biol (2003) 2.32
ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med (2005) 2.28
The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int J Radiat Oncol Biol Phys (2014) 2.28
Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res (2004) 2.26
Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgery. Int J Radiat Oncol Biol Phys (2009) 2.22
Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy. Phys Med Biol (2004) 2.15
Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol (2007) 2.10
Engaging the vascular component of the tumor response. Cancer Cell (2005) 2.05
Do we need "biology-based" models to describe cell survival curves after exposure to ionizing radiation? Z Med Phys (2015) 2.04
The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Semin Radiat Oncol (2008) 1.93
Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. Lancet Oncol (2014) 1.93
Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial. Radiother Oncol (2008) 1.88
The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin Radiat Oncol (2008) 1.74
Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res (2012) 1.70
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A (2011) 1.58
Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation, and telangiectasia after 3 and 5 year's follow-up. Radiother Oncol (1989) 1.55
Sphere of equivalence--a novel target volume concept for intraoperative radiotherapy using low-energy X rays. Int J Radiat Oncol Biol Phys (2008) 1.53
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group. Oncogene (2001) 1.51
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat Res (2010) 1.50
The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships. Radiat Res (1998) 1.49
Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy. World J Gastroenterol (2007) 1.42
Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding. Clin Cancer Res (2008) 1.34
Lethal and potentially lethal lesions induced by radiation--a unified repair model. Radiat Res (1986) 1.33
Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: results for cells deficient in nonhomologous end joining. Radiat Res (2003) 1.30
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Front Oncol (2013) 1.30
An 'incomplete-repair' model for survival after fractionated and continuous irradiations. Int J Radiat Biol Relat Stud Phys Chem Med (1985) 1.27
Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery. Int J Radiat Oncol Biol Phys (2010) 1.24
12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors. Int J Radiat Oncol Biol Phys (2005) 1.23
The role of homologous recombination in radiation-induced double-strand break repair. Radiother Oncol (2011) 1.21
Weiss Lecture. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. Int J Radiat Biol (1993) 1.20
Dose-rate effects in external beam radiotherapy redux. Radiother Oncol (2010) 1.20
A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy. Sci Transl Med (2010) 1.19
Complications from arteriovenous malformation radiosurgery: multivariate analysis and risk modeling. Int J Radiat Oncol Biol Phys (1997) 1.18
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat Res (2006) 1.16
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest (2012) 1.15
Multicentricity of breast cancer: whole-organ analysis and clinical implications. Br J Cancer (1996) 1.10
Toward a unified survival curve: in regard to Park et al. (IntJ Radiat Oncol Biol Phys 2008;70:847-852) and Krueger et al. (Int J Radiat Oncol Biol Phys 2007;69:1262-1271). Int J Radiat Oncol Biol Phys (2008) 1.07
Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A. Breast Cancer Res Treat (2012) 1.04
Accelerated partial breast irradiation with intraoperative electrons: using GEC-ESTRO recommendations as guidance for patient selection. Radiother Oncol (2012) 1.03
Single-center long-term follow-up after intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage x-rays. Ann Surg Oncol (2010) 1.01
Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother Oncol (1991) 1.01
IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis. Radiother Oncol (2013) 1.00
The 5Rs of radiobiology. Int J Radiat Biol (1989) 1.00
Electron spectra and the RBE of X rays. Radiat Res (2002) 1.00
Radiobiological aspects of intraoperative radiotherapy (IORT) with isotropic low-energy X rays for early-stage breast cancer. Radiat Res (2005) 1.00
Requirement for repair of DNA double-strand breaks by homologous recombination in split-dose recovery. Radiat Res (2001) 0.99
Present status and future directions of intraoperative radiotherapy. Lancet Oncol (2013) 0.98
Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations. Mutat Res Genet Toxicol Environ Mutagen (2015) 0.97
A dosimetric comparison of IORT techniques in limited-stage breast cancer. Strahlenther Onkol (2006) 0.97
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. Mutat Res (2010) 0.97
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res (2010) 0.96
Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining. Nucleic Acids Res (2014) 0.96
Induction of chromosome aberrations in human lymphocytes by monochromatic X-rays of quantum energy between 4.8 and 14.6 keV. Int J Radiat Biol (1989) 0.96
The relative biological effectiveness of 60Co gamma-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low doses. Int J Radiat Biol (1992) 0.95
Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated radiation doses to single doses. J Radiat Res (2012) 0.95
Cancer stem cells as a predictive factor in radiotherapy. Semin Radiat Oncol (2012) 0.95
Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells. Proc Natl Acad Sci U S A (2006) 0.94
ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombination. PLoS Genet (2013) 0.94
Quantitative clinical radiobiology of early and late lung reactions. Int J Radiat Biol (2000) 0.94
A new incomplete-repair model based on a 'reciprocal-time' pattern of sublethal damage repair. Acta Oncol (1999) 0.93
The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 "boost versus no boost" trial. Cancer Radiother (2008) 0.93
Ectopic expression of a COOH-terminal fragment of the human telomerase reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in HeLa cells. Cancer Res (2002) 0.92
RBE of low energy electrons and photons. Phys Med Biol (2010) 0.92
A novel device for intravaginal electronic brachytherapy. Int J Radiat Oncol Biol Phys (2009) 0.91
Soft X-ray dosimetry and RBE for survival of Chinese hamster V79 cells. Int J Radiat Biol (1988) 0.91
RBE of 20 kV and 70 kV X-rays determined for survival of V 79 cells. Radiother Oncol (1986) 0.90
In vivo optical imaging of tumor and microvascular response to ionizing radiation. PLoS One (2012) 0.90
Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devices. Phys Med Biol (1999) 0.90
DNA double-strand break repair in a cellular context. Clin Oncol (R Coll Radiol) (2014) 0.90
Normal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials. Radiother Oncol (2013) 0.90
The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlenther Onkol (1998) 0.90
Radiobiological comparison of hypofractionated accelerated partial-breast irradiation (APBI) and single-dose intraoperative radiotherapy (IORT) with 50-kV X-rays. Strahlenther Onkol (2010) 0.90
An integrated logistic formula for prediction of complications from radiosurgery. Int J Radiat Oncol Biol Phys (1989) 0.89
No apoptotic endothelial cells in irradiated intestine: regarding Schuller et al. (Int J Radiat Oncol Biol Phys 2007;68:205-210). Int J Radiat Oncol Biol Phys (2008) 0.89
Predicting realistic RBE values for clinically relevant radiotherapy schedules. Int J Radiat Biol (1997) 0.89
The biological effect of large single doses: a possible role for non-targeted effects in cell inactivation. PLoS One (2014) 0.89
Are mammographic changes in the tumor bed more pronounced after intraoperative radiotherapy for breast cancer? Subgroup analysis from a randomized trial (TARGIT-A). Breast J (2012) 0.88
Recovery from radiation damage in mouse lung: interpretation in terms of two rates of repair. Radiat Res (1993) 0.88
Clinical aspects of intraoperative radiotherapy in early breast cancer: short-term complications after IORT in women treated with low energy x-rays. Radiat Oncol (2013) 0.87
Intraoperative radiation therapy: a critical analysis of the ELIOT and TARGIT trials. Part 2--TARGIT. Ann Surg Oncol (2014) 0.87
IOERT as anticipated tumor bed boost during breast-conserving surgery after neoadjuvant chemotherapy in locally advanced breast cancer--results of a case series after 5-year follow-up. Int J Cancer (2014) 0.86