| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
|
Science
|
2004
|
17.38
|
|
2
|
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
|
Proc Natl Acad Sci U S A
|
2003
|
9.14
|
|
3
|
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
|
Mol Cell Biol
|
2007
|
7.97
|
|
4
|
Recent progress in the biology and physiology of sirtuins.
|
Nature
|
2009
|
7.73
|
|
5
|
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
|
EMBO J
|
2007
|
7.30
|
|
6
|
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
|
Cell
|
2006
|
6.79
|
|
7
|
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
|
Cell
|
2008
|
5.76
|
|
8
|
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
|
Cell
|
2008
|
5.68
|
|
9
|
DNA repair, genome stability, and aging.
|
Cell
|
2005
|
5.52
|
|
10
|
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
|
Proc Natl Acad Sci U S A
|
2008
|
5.48
|
|
11
|
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
|
Cell
|
2010
|
5.11
|
|
12
|
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
|
Annu Rev Immunol
|
2006
|
4.32
|
|
13
|
SIRT1 controls endothelial angiogenic functions during vascular growth.
|
Genes Dev
|
2007
|
3.34
|
|
14
|
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
|
Cell Metab
|
2005
|
3.15
|
|
15
|
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
|
Cell
|
2012
|
2.78
|
|
16
|
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
|
Genes Dev
|
2010
|
2.55
|
|
17
|
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.
|
Nature
|
2013
|
2.52
|
|
18
|
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
|
Nature
|
2011
|
2.47
|
|
19
|
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
|
Nat Med
|
2009
|
1.70
|
|
20
|
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
|
Nat Med
|
2012
|
1.69
|
|
21
|
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.
|
Nat Immunol
|
2007
|
1.68
|
|
22
|
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
|
Cell Metab
|
2010
|
1.64
|
|
23
|
From sirtuin biology to human diseases: an update.
|
J Biol Chem
|
2012
|
1.60
|
|
24
|
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
|
Mol Cell
|
2011
|
1.55
|
|
25
|
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.
|
Mol Cell
|
2013
|
1.47
|
|
26
|
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
|
Mol Cell
|
2012
|
1.39
|
|
27
|
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
|
PLoS One
|
2009
|
1.30
|
|
28
|
Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.
|
Endocrinology
|
2011
|
1.11
|
|
29
|
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
|
J Biol Chem
|
2012
|
1.11
|
|
30
|
SIRT6: a master epigenetic gatekeeper of glucose metabolism.
|
Transcription
|
2012
|
1.06
|
|
31
|
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.
|
J Biol Chem
|
2010
|
1.06
|
|
32
|
Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction.
|
Antioxid Redox Signal
|
2012
|
1.04
|
|
33
|
Mitochondria, energetics, epigenetics, and cellular responses to stress.
|
Environ Health Perspect
|
2014
|
1.03
|
|
34
|
Fine tuning our cellular factories: sirtuins in mitochondrial biology.
|
Cell Metab
|
2011
|
1.00
|
|
35
|
Sirtuins, metabolism, and cancer.
|
Front Pharmacol
|
2012
|
0.91
|
|
36
|
Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.
|
Eur J Immunol
|
2008
|
0.88
|
|
37
|
Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.
|
FEBS Lett
|
2008
|
0.87
|
|
38
|
A tale of metabolites: the cross-talk between chromatin and energy metabolism.
|
Cancer Discov
|
2013
|
0.87
|
|
39
|
Metabolism, longevity and epigenetics.
|
Cell Mol Life Sci
|
2013
|
0.85
|
|
40
|
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease.
|
Curr Top Med Chem
|
2013
|
0.84
|
|
41
|
SIRT3 in calorie restriction: can you hear me now?
|
Cell
|
2010
|
0.83
|
|
42
|
Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.
|
Handb Exp Pharmacol
|
2011
|
0.82
|
|
43
|
eNERgizing pluripotent gene transcription.
|
Cell Stem Cell
|
2011
|
0.79
|
|
44
|
SIRT1 activators: the evidence STACks up.
|
Aging (Albany NY)
|
2013
|
0.78
|
|
45
|
SIRT3 deacetylase: the Jekyll and Hyde sirtuin.
|
EMBO Rep
|
2011
|
0.78
|
|
46
|
Cell Fate by SIRT6 and TETs.
|
Cell Cycle
|
2015
|
0.75
|