Strategies for gene disruption in Drosophila.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4216337)

Published in Cell Biosci on October 14, 2014

Authors

Shih-Ching Lin1, Yu-Yun Chang2, Chih-Chiang Chan3

Author Affiliations

1: Graduate Institute of Physiology, National Taiwan University, No.1, Sec. 1, Jen-Ai Rd., Zhongzheng Dist, Taipei, 100 Taiwan.
2: Graduate Institute of Molecular Medicine, National Taiwan University, No.1, Sec. 1, Jen-Ai Rd., Zhongzheng Dist, Taipei, 100 Taiwan.
3: Graduate Institute of Physiology, National Taiwan University, No.1, Sec. 1, Jen-Ai Rd., Zhongzheng Dist, Taipei, 100 Taiwan ; Graduate Institute of Brain and Mind Sciences, National Taiwan University, No.1, Sec. 1, Jen-Ai Rd., Zhongzheng Dist, Taipei, 100 Taiwan.

Articles cited by this

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17

Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33

X-Ray Induced Chromosomal Alterations in Drosophila Melanogaster. Genetics (1938) 19.92

Genetic applications of an inverse polymerase chain reaction. Genetics (1988) 18.48

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35

Genetic screens in human cells using the CRISPR-Cas9 system. Science (2013) 10.75

Targeted genome editing across species using ZFNs and TALENs. Science (2011) 9.84

Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics (2002) 9.09

Insertional mutagenesis of the Drosophila genome with single P elements. Science (1988) 8.81

Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics (2013) 8.56

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol (2013) 8.40

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol (1996) 7.33

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods (2011) 6.90

Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors. Proc Natl Acad Sci U S A (2010) 5.65

Ends-out, or replacement, gene targeting in Drosophila. Proc Natl Acad Sci U S A (2003) 5.55

Sensing and repairing DNA double-strand breaks. Carcinogenesis (2002) 5.52

Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol (1987) 5.28

Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep (2013) 4.72

Efficient gene targeting in Drosophila with zinc-finger nucleases. Genetics (2006) 4.47

Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev (2002) 4.21

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res (2013) 4.11

The art and design of genetic screens: Drosophila melanogaster. Nat Rev Genet (2002) 3.86

Preferential transposition of Drosophila P elements to nearby chromosomal sites. Genetics (1993) 3.67

Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Res (2005) 3.47

Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods (2009) 3.35

Insertion site preferences of the P transposable element in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.22

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc Natl Acad Sci U S A (1996) 3.21

Highly specific and efficient CRISPR/Cas9-catalyzed homology-directed repair in Drosophila. Genetics (2014) 3.07

Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab (2007) 2.99

Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy. J Genet Genomics (2012) 2.98

Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics (2013) 2.87

MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods (2011) 2.76

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res (2001) 2.73

Targeted recovery of mutations in Drosophila. Genetics (2000) 2.71

Identification of EMS-induced mutations in Drosophila melanogaster by whole-genome sequencing. Genetics (2009) 2.61

High-resolution, high-throughput SNP mapping in Drosophila melanogaster. Nat Methods (2008) 2.55

Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics (2013) 2.50

The Drosophila gene disruption project: progress using transposons with distinctive site specificities. Genetics (2011) 2.45

Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 2.39

A Correlation of Cytological and Genetical Crossing-Over in Zea Mays. Proc Natl Acad Sci U S A (1931) 2.35

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25

Systematic discovery of Rab GTPases with synaptic functions in Drosophila. Curr Biol (2011) 1.99

Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A (2003) 1.94

Target-selected mutant screen by TILLING in Drosophila. Genome Res (2005) 1.83

Efficient ends-out gene targeting in Drosophila. Genetics (2008) 1.74

A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila. Proc Natl Acad Sci U S A (2008) 1.69

Drosophila models of neurodegenerative diseases. Annu Rev Pathol (2009) 1.67

I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila. Genetics (1999) 1.49

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly. Nucleic Acids Res (2013) 1.40

Splinkerette PCR for mapping transposable elements in Drosophila. PLoS One (2010) 1.29

Mutational specificity of ethyl methanesulfonate in excision-repair-proficient and -deficient strains of Drosophila melanogaster. Mol Gen Genet (1991) 1.26

Gene deletions by ends-in targeting in Drosophila melanogaster. Genetics (2004) 1.20

Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. G3 (Bethesda) (2013) 1.14

Drosophila P elements preferentially transpose to replication origins. Proc Natl Acad Sci U S A (2011) 1.11

The interplay of homologous recombination and horizontal gene transfer in bacterial speciation. Methods Mol Biol (2009) 1.07

Efficient gene knock-out and knock-in with transgenic Cas9 in Drosophila. G3 (Bethesda) (2014) 0.93

Combining recombineering and ends-out homologous recombination to systematically characterize Drosophila gene families: Rab GTPases as a case study. Commun Integr Biol (2012) 0.92

W::Neo: a novel dual-selection marker for high efficiency gene targeting in Drosophila. PLoS One (2012) 0.89

New horizons in genome engineering of Drosophila melanogaster. Genes Genet Syst (2014) 0.84

Modeling cancers in Drosophila. Prog Mol Biol Transl Sci (2011) 0.81

High-efficiency gene targeting in Drosophila with zinc finger nucleases. Methods Mol Biol (2010) 0.79

DroPhEA: Drosophila phenotype enrichment analysis for insect functional genomics. Bioinformatics (2011) 0.78