The intact human acetylcholinesterase C-terminal oligomerization domain is alpha-helical in situ and in isolation, but a shorter fragment forms beta-sheet-rich amyloid fibrils and protofibrillar oligomers.

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Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease. PLoS One (2007) 0.87

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