Published in PLoS One on July 25, 2007
Genesis of mammalian prions: from non-infectious amyloid fibrils to a transmissible prion disease. PLoS Pathog (2011) 1.53
Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis. Transl Neurodegener (2012) 0.98
Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides. PLoS One (2009) 0.90
Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits. Mol Vis (2013) 0.85
Structural elements regulating amyloidogenesis: a cholinesterase model system. PLoS One (2008) 0.80
β-amyloid oligomers and prion protein: Fatal attraction? Prion (2011) 0.80
Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism. Int J Cell Biol (2013) 0.79
Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment. Exp Ther Med (2016) 0.75
Conformational preferences of a 14-residue fibrillogenic peptide from acetylcholinesterase. Biochemistry (2010) 0.75
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69
Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. Anal Biochem (2000) 11.10
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69
Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem (1997) 7.62
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol (1999) 7.16
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci (2007) 6.27
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem (2002) 5.63
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A (2003) 5.44
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol (2004) 4.63
Metabolic regulation of brain Abeta by neprilysin. Science (2001) 4.47
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem (2004) 4.33
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron (2003) 4.11
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem (1998) 3.77
Insulin degradation: progress and potential. Endocr Rev (1998) 3.57
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. J Mol Biol (2001) 3.26
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature (2006) 3.21
Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol (1994) 3.19
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (2000) 3.16
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol (2002) 2.92
Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy. Protein Sci (2000) 2.23
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci (2000) 2.22
Prediction of amyloid fibril-forming proteins. J Biol Chem (2000) 2.12
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A (2003) 2.02
Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation. J Biol Chem (1994) 1.88
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron (1996) 1.84
Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol (1978) 1.82
Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol (2003) 1.81
The toxicity of the Alzheimer's beta-amyloid peptide correlates with a distinct fiber morphology. J Struct Biol (1997) 1.78
Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity. J Biol Chem (2000) 1.76
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide. Neurosci Lett (2001) 1.75
Insulin-degrading enzyme: embarking on amyloid destruction. Trends Biochem Sci (2001) 1.75
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res (2004) 1.75
Conformational flexibility of the acetylcholinesterase tetramer suggested by x-ray crystallography. J Biol Chem (1999) 1.72
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging (2005) 1.68
Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis. J Mol Biol (2001) 1.57
The prion folding problem. Curr Opin Struct Biol (1997) 1.52
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem Res (2000) 1.46
Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem (1997) 1.43
Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience (2002) 1.41
The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals (2002) 1.39
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci U S A (2001) 1.32
Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases? J Neurochem (2002) 1.30
Butyrylcholinesterase in the life cycle of amyloid plaques. Ann Neurol (1997) 1.27
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J (2004) 1.27
Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth. Eur J Biochem (1999) 1.27
Detecting hidden sequence propensity for amyloid fibril formation. Protein Sci (2004) 1.25
Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci Lett (2003) 1.23
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol Aging (2003) 1.19
Modulation of S6 fibrillation by unfolding rates and gatekeeper residues. J Mol Biol (2004) 1.17
Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins. Peptides (2002) 1.10
Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proc Natl Acad Sci U S A (2006) 1.08
Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles. Ann Neurol (1987) 1.06
Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates. J Biol Chem (2001) 1.05
Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci (1998) 1.03
Design of peptides undergoing self-catalytic alpha-to-beta transition and amyloidogenesis. Biopolymers (1998) 1.01
Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Ann Neurol (1993) 1.01
Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease. J Neurochem (1999) 0.99
Rapid method for measurement of surface tension in multiwell plates. Lab Invest (2004) 0.98
Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit. J Neural Transm (Vienna) (2002) 0.96
Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Curr Alzheimer Res (2005) 0.96
Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide. Biochemistry (2002) 0.95
Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain Res (1989) 0.92
The intact human acetylcholinesterase C-terminal oligomerization domain is alpha-helical in situ and in isolation, but a shorter fragment forms beta-sheet-rich amyloid fibrils and protofibrillar oligomers. Biochemistry (2003) 0.83
Characterization of salt-soluble forms of acetylcholinesterase from bovine brain. J Neurochem (1994) 0.77
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science (2009) 25.61
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med (2010) 9.90
Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J Infect Dis (2007) 5.21
U1 snRNA associates with TFIIH and regulates transcriptional initiation. Nat Struct Biol (2002) 3.25
Screening for Barrett's esophagus in colonoscopy patients with and without heartburn. Gastroenterology (2003) 2.59
Design of treatment trials for functional gastrointestinal disorders. Gastroenterology (2006) 2.58
Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001. J Virol (2005) 2.51
Outbreak of variant influenza A(H3N2) virus in the United States. Clin Infect Dis (2013) 2.38
Localisation of DivIVA by targeting to negatively curved membranes. EMBO J (2009) 2.35
Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB. Mol Microbiol (2008) 2.27
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences. Blood (2013) 2.14
Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. J Virol (2006) 1.93
Hedgehog signaling regulates nociceptive sensitization. Curr Biol (2011) 1.81
Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Nature (2004) 1.66
The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation. Cell Cycle (2010) 1.61
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60
Clinical effectiveness of laparoscopic fundoplication in a U.S. community. Am J Med (2003) 1.57
Lamin B1 controls oxidative stress responses via Oct-1. J Cell Biol (2009) 1.56
Life-threatening hyperkalaemia following therapeutic barbiturate coma. Intensive Care Med (2002) 1.54
CPFP: a central proteomics facilities pipeline. Bioinformatics (2010) 1.53
Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression. J Cell Biol (2007) 1.53
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3. Exp Hematol (2008) 1.52
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. J Leukoc Biol (2010) 1.50
The nucleoplasmic reticulum: form and function. Trends Cell Biol (2011) 1.48
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. Hum Mol Genet (2011) 1.47
A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading. J Biol Chem (2003) 1.36
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation. J Cell Sci (2006) 1.32
Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline. Proteomics (2011) 1.30
R292K substitution and drug susceptibility of influenza A(H7N9) viruses. Emerg Infect Dis (2013) 1.25
A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans. Genome Biol (2007) 1.24
Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion. J Biol Chem (2003) 1.20
Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum. J Biol Chem (2008) 1.19
QuaNCAT: quantitating proteome dynamics in primary cells. Nat Methods (2013) 1.18
Labile disulfide bonds are common at the leucocyte cell surface. Open Biol (2011) 1.14
Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. PLoS Pathog (2012) 1.11
Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. Mol Biol Cell (2004) 1.09
A method for large-scale identification of protein arginine methylation. Mol Cell Proteomics (2012) 1.08
A novel role for BRCA1 in regulating breast cancer cell spreading and motility. J Cell Biol (2011) 1.08
A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation. J Cell Biol (2003) 1.08
The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int J Cancer (2006) 1.05
Oligomerization of the human prion protein proceeds via a molten globule intermediate. J Biol Chem (2007) 1.04
Mineral dust photochemistry induces nucleation events in the presence of SO2. Proc Natl Acad Sci U S A (2012) 1.04
Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Dis Model Mech (2010) 1.04
Differences in influenza seasonality by latitude, northern India. Emerg Infect Dis (2014) 1.02
Structural determinants of conformationally selective, prion-binding aptamers. J Biol Chem (2004) 1.00
Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008. Influenza Other Respir Viruses (2009) 0.99
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res (2012) 0.98
Genetic analysis of avian influenza A viruses isolated from domestic waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1 human infections in 2004. Arch Virol (2009) 0.97
Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT. J Virol (2010) 0.96
Experiments on mixotrophic protists and catastrophic darkness. Astrobiology (2009) 0.95
A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles. Int J Exp Pathol (2006) 0.94
Analysis of U1 small nuclear RNA interaction with cyclin H. J Biol Chem (2005) 0.94
Host cell proteins interacting with the 3' end of TGEV coronavirus genome influence virus replication. Virology (2009) 0.94
Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States. Antiviral Res (2012) 0.93
Competing discrete interfacial effects are critical for amyloidogenesis. FASEB J (2009) 0.93
Isolation and characterization of TgVP1, a type I vacuolar H+-translocating pyrophosphatase from Toxoplasma gondii. The dynamics of its subcellular localization and the cellular effects of a diphosphonate inhibitor. J Biol Chem (2002) 0.91
The presence of valine at residue 129 in human prion protein accelerates amyloid formation. FEBS Lett (2005) 0.91
The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α. J Cell Sci (2012) 0.91
Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice. PLoS Genet (2012) 0.90
HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy? Biochem Soc Trans (2010) 0.89
The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells. J Exp Med (2003) 0.89
Conformational pH dependence of intermediate states during oligomerization of the human prion protein. Protein Sci (2008) 0.88
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions. Cell Immunol (2011) 0.87
Polarization effects on contrast in structured illumination microscopy. Opt Lett (2012) 0.86
Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine. Adv Mater (2014) 0.86
Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E. Biochemistry (2009) 0.85
Prevalence of hyperprolactinaemia in a naturalistic cohort of schizophrenia and bipolar outpatients during treatment with typical and atypical antipsychotics. J Psychopharmacol (2007) 0.85
Activation of AP-1-dependent transcription by a truncated translation initiation factor. Eukaryot Cell (2005) 0.85
Combined effects of agitation, macromolecular crowding, and interfaces on amyloidogenesis. J Biol Chem (2012) 0.85
Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity. Biomaterials (2013) 0.85
Elongation dynamics of amyloid fibrils: a rugged energy landscape picture. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 0.84
Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast. J Mol Biol (2011) 0.84
Mutations in congenital myasthenic syndromes reveal an epsilon subunit C-terminal cysteine, C470, crucial for maturation and surface expression of adult AChR. Hum Mol Genet (2002) 0.84
Identifying patients with gastroesophageal reflux disease: validation of a practical screening tool. Dig Dis Sci (2002) 0.83
A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition. Plant J (2015) 0.83
Arbitrary self-assembly of peptide extracellular microscopic matrices. Angew Chem Int Ed Engl (2011) 0.82
A review of the association between antipsychotic use and hyperprolactinaemia. J Psychopharmacol (2008) 0.82
Rheonix CARD(®) Technology: An Innovative and Fully Automated Molecular Diagnostic Device. Point Care (2012) 0.82
Enrichment of amyloidogenesis at an air-water interface. Biophys J (2012) 0.82
Inter-oligomer interactions of the human prion protein are modulated by the polymorphism at codon 129. J Mol Biol (2008) 0.82
Prevalence of Barrett's Esophagus. Gastroenterology (2006) 0.81
The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase. New Phytol (2010) 0.80
Structural elements regulating amyloidogenesis: a cholinesterase model system. PLoS One (2008) 0.80
The nuclear envelope and its involvement in cellular stress responses. Biochem Soc Trans (2011) 0.80
Preparing for the availability of a partially effective HIV vaccine: some lessons from other licensed vaccines. Vaccine (2011) 0.80
Self-selection and use patterns of over-the-counter omeprazole for frequent heartburn. Clin Gastroenterol Hepatol (2004) 0.80
Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection. J Immunol (2011) 0.80
Targeting cardiovascular protection: the concept of dual renin-angiotensin system control. Medscape J Med (2008) 0.80
Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS. Proteomics (2005) 0.79
No HOPE without proof: do ARBs meet the standard for cardiovascular protection? Medscape J Med (2008) 0.79
Transcription factor sequestration by nuclear envelope components. Cell Cycle (2009) 0.79