Published in Dev Cell on September 01, 2003
BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell (2006) 2.37
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells. J Cell Biol (2005) 1.40
Two human ARFGAPs associated with COP-I-coated vesicles. Traffic (2007) 1.23
Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex. Biochem J (2007) 1.14
A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor. EMBO Rep (2008) 1.10
Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. J Cell Biol (2008) 1.10
Protein networks supporting AP-3 function in targeting lysosomal membrane proteins. Mol Biol Cell (2008) 1.09
A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis. Mol Biol Cell (2005) 1.09
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. EMBO J (2010) 1.05
SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. Mol Biol Cell (2006) 1.03
Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity. Cell Signal (2008) 0.94
A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes. J Biol Chem (2009) 0.92
Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy. Mol Psychiatry (2015) 0.84
Arf GAP2 is positively regulated by coatomer and cargo. Cell Signal (2009) 0.84
AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity. J Neurosci (2013) 0.83
Post-Golgi protein traffic in the plant secretory pathway. Plant Cell Rep (2007) 0.83
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. J Biol Chem (2012) 0.83
Discolored1 (DSC1) is an ADP-Ribosylation Factor-GTPase Activating Protein Required to Maintain Differentiation of Maize Kernel Structures. Front Plant Sci (2012) 0.79
Putative terminator and/or effector functions of Arf GAPs in the trafficking of clathrin-coated vesicles. Cell Logist (2011) 0.79
ArfGAP1 promotes COPI vesicle formation by facilitating coatomer polymerization. Cell Logist (2011) 0.77
The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin. Front Cell Neurosci (2016) 0.76
Allosteric properties of PH domains in Arf regulatory proteins. Cell Logist (2016) 0.76
ArfGAPs: key regulators for receptor sorting. Receptors Clin Investig (2014) 0.75
Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster. PLoS One (2015) 0.75
Direct Functional Interaction of the Kinesin-13 family membrane Kinesin Like Protein 2A (Kif2A) and Arf GAP with GTP-Binding Protein-Like, Ankyrin Repeats and PH domains1 (AGAP1). J Biol Chem (2016) 0.75
Imaging intracellular fluorescent proteins at nanometer resolution. Science (2006) 38.97
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol (2004) 4.24
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell (2002) 4.13
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A (2005) 3.85
A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J (2002) 3.35
Sorting of lysosomal proteins. Biochim Biophys Acta (2008) 2.86
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85
Interactions of GGA3 with the ubiquitin sorting machinery. Nat Cell Biol (2004) 2.63
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell (2005) 2.56
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol (2008) 2.56
Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell (2002) 2.55
Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res (2008) 2.36
Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4. EMBO J (2009) 2.34
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes. J Cell Biol (2003) 2.24
Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. Mol Biol Cell (2004) 2.10
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature (2002) 2.09
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol (2006) 2.05
Coatomer-dependent protein delivery to lipid droplets. J Cell Sci (2009) 2.01
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins. Mol Biol Cell (2005) 1.99
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. J Cell Biol (2002) 1.98
Arf and its many interactors. Curr Opin Cell Biol (2003) 1.94
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A (2007) 1.87
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. J Cell Biol (2002) 1.82
The retromer complex and clathrin define an early endosomal retrograde exit site. J Cell Sci (2007) 1.80
Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A (2010) 1.78
Germline mutations in PRKCSH are associated with autosomal dominant polycystic liver disease. Nat Genet (2003) 1.77
Arf GAPs and their interacting proteins. Traffic (2007) 1.76
Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network. Mol Biol Cell (2003) 1.70
Genetic analyses of adaptin function from yeast to mammals. Gene (2002) 1.70
The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain. J Biol Chem (2006) 1.68
Arf GAPs and membrane traffic. J Cell Sci (2006) 1.67
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood (2008) 1.67
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps. PLoS Pathog (2010) 1.66
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Res (2006) 1.64
Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. EMBO J (2003) 1.63
PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell (2007) 1.63
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther (2014) 1.56
ARAP1: a point of convergence for Arf and Rho signaling. Mol Cell (2002) 1.53
Intramolecular cross-linking experiments on cytochrome c and ribonuclease A using an isotope multiplet method. Rapid Commun Mass Spectrom (2002) 1.52
Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol (2010) 1.50
Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. Immunity (2002) 1.50
Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. Mol Biol Cell (2008) 1.49
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell (2012) 1.47
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proc Natl Acad Sci U S A (2005) 1.47
Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. Traffic (2002) 1.44
Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol (2008) 1.42
Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses. Curr Mol Med (2007) 1.41
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. Mol Biol Cell (2008) 1.40
A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor. Curr Biol (2006) 1.40
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. J Biol Chem (2002) 1.37
The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Dev Cell (2007) 1.36
Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3. Nat Struct Biol (2003) 1.36
BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4. J Biol Chem (2003) 1.35
Structural characterization of native mouse zona pellucida proteins using mass spectrometry. J Biol Chem (2003) 1.35
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell (2004) 1.34
Mitochondrial NADH fluorescence is enhanced by complex I binding. Biochemistry (2008) 1.30
Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein. Development (2009) 1.30
Definition of the consensus motif recognized by gamma-adaptin ear domains. J Biol Chem (2003) 1.29
Polycystic liver disease is a disorder of cotranslational protein processing. Trends Mol Med (2005) 1.28
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. Mol Cell Biol (2009) 1.27
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. Blood (2005) 1.27
Cargo recognition in clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol (2013) 1.27
Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell (2013) 1.26
Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol (2005) 1.26
A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J Virol (2007) 1.25
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol (2006) 1.24
Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network. Mol Biol Cell (2003) 1.24
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J Cell Sci (2006) 1.21
Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes. EMBO J (2008) 1.21
Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Mol Biol Cell (2002) 1.20
Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons. Neuron (2012) 1.20
Statistical design for biospecimen cohort size in proteomics-based biomarker discovery and verification studies. J Proteome Res (2013) 1.20
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem (2010) 1.19
Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B. Proc Natl Acad Sci U S A (2012) 1.18
Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). Blood (2003) 1.18
Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein. J Biol Chem (2010) 1.18
Modifications to the C-terminus of Arf1 alter cell functions and protein interactions. Traffic (2010) 1.17
Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex. Blood (2004) 1.17
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. J Virol (2009) 1.17
Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem (2009) 1.17
Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Proc Natl Acad Sci U S A (2005) 1.16
Ultrastructure of long-range transport carriers moving from the trans Golgi network to peripheral endosomes. Traffic (2006) 1.16
Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism. Nat Struct Biol (2002) 1.16
Preparation of myristoylated Arf1 and Arf6. Methods Enzymol (2005) 1.15
The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting. Mol Biol Cell (2007) 1.15
Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. Cancer Res (2012) 1.14
Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex. Biochem J (2007) 1.14
The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. J Cell Sci (2005) 1.14
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. Cancer Cell (2009) 1.14
Phosphoproteomic profiling reveals vasopressin-regulated phosphorylation sites in collecting duct. J Am Soc Nephrol (2010) 1.13
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. J Biol Chem (2008) 1.12