Published in Clin Exp Metastasis on November 13, 2015
The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. J Bone Oncol (2016) 0.76
How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases. J Vis Exp (2016) 0.75
Endo180 at the cutting edge of bone cancer treatment and beyond. J Pathol (2016) 0.75
Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40
Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01
Lysyl oxidase is essential for hypoxia-induced metastasis. Nature (2006) 8.28
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89
Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol (1979) 6.96
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell (2009) 6.66
Cancer invasion and the microenvironment: plasticity and reciprocity. Cell (2011) 6.36
Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem (2003) 4.58
Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer (1978) 4.04
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol (2006) 3.55
VCaP, a cell-based model system of human prostate cancer. In Vivo (2001) 3.36
Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci (2006) 3.31
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature (2015) 3.24
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell (2011) 2.77
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol (2008) 2.27
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Bone metastasis in prostate cancer: emerging therapeutic strategies. Nat Rev Clin Oncol (2011) 2.20
Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices. J Cell Biol (2007) 2.17
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc Natl Acad Sci U S A (2011) 1.98
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene (2009) 1.87
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol (2006) 1.76
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol (2008) 1.75
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene (2006) 1.73
Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol (2003) 1.60
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. Oncogene (2009) 1.54
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene (2010) 1.50
MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion. PLoS One (2010) 1.50
Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol (2008) 1.49
Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Res (1999) 1.48
New dimensions in cell migration. Nat Rev Mol Cell Biol (2012) 1.46
Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell (2003) 1.44
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol (2005) 1.42
EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style. Cancer Res (2009) 1.39
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. Oncogene (2012) 1.35
A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One (2010) 1.34
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep (2003) 1.31
An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells. J Cell Sci (2011) 1.28
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal (2010) 1.27
HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology (2011) 1.21
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol (2011) 1.17
Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone. J Orthop Res (2003) 1.14
Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol (2006) 1.12
GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol (2003) 1.10
Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment. Biomaterials (2010) 1.08
EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells. Mol Cancer Res (2011) 1.06
Preclinical evaluation of imaging biomarkers for prostate cancer bone metastasis and response to cabozantinib. J Natl Cancer Inst (2014) 1.01
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. J Cell Sci (2009) 1.00
SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells. Mol Cancer (2011) 0.98
Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147. Mol Cancer Res (2014) 0.91
Expression of Endo180 is spatially and temporally regulated during wound healing. Histopathology (2006) 0.91
LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices. Biochem Biophys Res Commun (2010) 0.90
Pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition. PLoS One (2012) 0.88
Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180. Biochem J (2005) 0.88
A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone. Clin Exp Metastasis (2014) 0.87
TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. J Pathol (2011) 0.87
AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival. J Pathol (2014) 0.87
Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. Br J Cancer (2012) 0.86
Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells. J Neurooncol (2010) 0.86
The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style. Oncotarget (2014) 0.85
A supra-cellular model for coupling of bone resorption to formation during remodeling: lessons from two bone resorption inhibitors affecting bone formation differently. Biochem Biophys Res Commun (2013) 0.83
Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix. Tissue Eng Part C Methods (2015) 0.77