Published in Mol Cell Biol on October 01, 2003
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov (2010) 3.84
Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron (2008) 2.29
Polo-box domain: a versatile mediator of polo-like kinase function. Cell Mol Life Sci (2010) 1.85
Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem (2008) 1.54
PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem (2009) 1.51
From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle (2011) 1.36
Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One (2008) 1.32
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res (2008) 1.26
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle (2009) 1.18
CIB1 is essential for mouse spermatogenesis. Mol Cell Biol (2006) 1.17
Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Neuron (2011) 1.13
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment. Transl Oncol (2015) 1.12
Polo-like kinases mediate cell survival in mitochondrial dysfunction. Proc Natl Acad Sci U S A (2009) 1.10
BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival. Mol Cell Biol (2004) 1.03
The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Nucleic Acids Res (2010) 1.02
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res (2015) 1.01
Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review. Mol Cancer (2006) 1.00
Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J Virol (2006) 0.99
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. PLoS One (2010) 0.97
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J Cell Sci (2012) 0.91
Reduced fertility in male mice deficient in the zinc metallopeptidase NL1. Mol Cell Biol (2004) 0.90
The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials (2014) 0.89
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy. Trends Pharmacol Sci (2015) 0.87
Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget (2013) 0.86
The role of Plk3 in oncogenesis. Oncogene (2015) 0.83
Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development. Protein Cell (2012) 0.83
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding. J Biol Chem (2013) 0.82
Plk2 regulates mitotic spindle orientation and mammary gland development. Development (2014) 0.78
Hormonal induction of polo-like kinases (Plks) and impact of Plk2 on cell cycle progression in the rat ovary. PLoS One (2012) 0.77
A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay. PLoS One (2013) 0.76
Putting a bit into the polo-box domain of polo-like kinase 1. J Anal Sci Technol (2015) 0.76
Amnion as a surrogate tissue reporter of the effects of maternal preeclampsia on the fetus. Clin Epigenetics (2016) 0.75
MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression. Arterioscler Thromb Vasc Biol (2016) 0.75
PLK2 phosphorylates and inhibits enriched TAp73 in human osteosarcoma cells. Cancer Med (2015) 0.75
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol (1963) 29.15
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell (1996) 8.77
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell (1996) 8.41
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science (1996) 8.14
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell (1996) 7.69
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J Cell Biol (1996) 5.17
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J (1998) 5.00
polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci (1988) 4.77
Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev (1995) 4.64
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science (1996) 4.60
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18
CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell (1997) 3.83
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev (1995) 3.52
Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol (2000) 3.49
Gene targeting in embryonic stem cells. Methods Enzymol (1993) 3.41
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell (2001) 2.99
Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J (1994) 2.95
PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression. Mol Cell (1998) 2.75
Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev (1992) 2.72
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol (1999) 2.65
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J (1994) 2.61
Rescue of cyclin D1 deficiency by knockin cyclin E. Cell (1999) 2.54
The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J (1998) 2.48
Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature (2001) 2.47
Identification of an early-growth-response gene encoding a novel putative protein kinase. Mol Cell Biol (1992) 2.39
Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell (2001) 2.33
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis. Mol Cell Biol (1998) 2.32
Drosophila polo kinase is required for cytokinesis. J Cell Biol (1998) 2.30
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc Natl Acad Sci U S A (2002) 2.23
Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures. Mol Cell Biol (1997) 2.22
Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. J Biol Chem (2002) 2.15
Genetics of mouse growth. Int J Dev Biol (1998) 2.08
Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1. Mol Cell Biol (1999) 1.87
A novel role for Cdc5p in DNA replication. Mol Cell Biol (1996) 1.84
Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem (1995) 1.80
The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J (1999) 1.75
The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes. Mol Biol Cell (2001) 1.70
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem (2001) 1.66
A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis. J Cell Biol (2001) 1.63
Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2. Proc Natl Acad Sci U S A (2000) 1.62
Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis. Proc Natl Acad Sci U S A (2001) 1.59
Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis. Cell (1981) 1.50
Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions. J Biol Chem (1997) 1.50
Cell-cycle control: POLO-like kinases join the outer circle. Trends Cell Biol (1997) 1.46
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol (2002) 1.44
Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes. Nat Cell Biol (2001) 1.42
Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. Cancer Res (2000) 1.23
Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor. Cell (1981) 1.20
The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. Mol Cancer Res (2003) 1.10
Polo-like kinase interacts with proteasomes and regulates their activity. Cell Growth Differ (2001) 1.02
Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression. Biochem J (1998) 1.01
Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. Oncogene (2000) 0.97
Cloning and characterization of Plx2 and Plx3, two additional Polo-like kinases from Xenopus laevis. Exp Cell Res (2001) 0.88
Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci U S A (2003) 2.81
Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol (2006) 2.63
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell (2011) 2.28
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc Natl Acad Sci U S A (2002) 2.23
Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. J Biol Chem (2002) 2.15
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase. Proc Natl Acad Sci U S A (2002) 2.03
MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron (2012) 1.68
B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med (2014) 1.65
A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell (2003) 1.55
Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia. Dev Cell (2007) 1.54
The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene (2004) 1.51
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol Cell (2012) 1.50
Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). Proc Natl Acad Sci U S A (2006) 1.47
Mek2 is dispensable for mouse growth and development. Mol Cell Biol (2003) 1.44
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci U S A (2008) 1.40
Polo-like kinase 3 is required for entry into S phase. Proc Natl Acad Sci U S A (2007) 1.37
Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1. J Virol (2006) 1.35
Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-priming. Cell Cycle (2007) 1.33
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation. Mol Cell Biol (2009) 1.25
Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1. J Cell Sci (2004) 1.24
Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A (2013) 1.18
Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1. Proc Natl Acad Sci U S A (2011) 1.15
CCT chaperonin complex is required for the biogenesis of functional Plk1. Mol Cell Biol (2005) 1.14
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development (2006) 1.14
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest (2013) 1.14
Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways. J Biol Chem (2013) 1.13
The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. Mol Cancer Res (2003) 1.10
A mammalian NudC-like protein essential for dynein stability and cell viability. Proc Natl Acad Sci U S A (2006) 1.09
Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia. Cancer Res (2009) 1.08
Essential role of Cenexin1, but not Odf2, in ciliogenesis. Cell Cycle (2013) 0.99
The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. Mol Endocrinol (2011) 0.99
Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate. Proc Natl Acad Sci U S A (2011) 0.96
Polo-like kinase 1 in the life and death of cancer cells. Cell Cycle (2003) 0.91
Reduced fertility in male mice deficient in the zinc metallopeptidase NL1. Mol Cell Biol (2004) 0.90
Monitoring the cell cycle by multi-kinase-dependent regulation of Swe1/Wee1 in budding yeast. Cell Cycle (2005) 0.89
The nuclear localization signal of mitotic kinesin-like protein Mklp-1: effect on Mklp-1 function during cytokinesis. Biochem Biophys Res Commun (2006) 0.87
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. Proc Natl Acad Sci U S A (2010) 0.87
Finding Plk3. Cell Cycle (2007) 0.86
Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development (2009) 0.86
Plk1-targeted therapies in TP53- or RAS-mutated cancer. Mutat Res Rev Mutat Res (2014) 0.85
Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase. Cell Cycle (2011) 0.84
Ectopic expression of Plk1 leads to activation of the spindle checkpoint. Cell Cycle (2006) 0.84
Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol Cell Biol (2010) 0.81
Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates. Acta Crystallogr D Biol Crystallogr (2013) 0.81
A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1. Cancer Prev Res (Phila) (2013) 0.79
A self-propelled biological process: Plk1-dependent, product-activated feedforward mechanism. Cell Cycle (2011) 0.78
A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases. J Biol Chem (2013) 0.78
Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis. Bioorg Med Chem Lett (2012) 0.78
Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation. Sci Rep (2013) 0.78
Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H. Biosci Rep (2012) 0.77
Crystal structure of constitutively monomeric E. coli Hsp33 mutant with chaperone activity. FEBS Lett (2011) 0.76
[Mek1 and Mek2 functions in the formation of the blood placental barrier]. Med Sci (Paris) (2012) 0.75
Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development (2015) 0.75
Synthesis and antitumor activity of natural compound aloe emodin derivatives. Chem Biol Drug Des (2014) 0.75