Published in J Biol Chem on September 16, 2003
FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci (2004) 2.31
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Heme binding inhibits the fibrillization of amyloidogenic apomyoglobin and determines lack of aggregate cytotoxicity. Protein Sci (2007) 0.85
Amyloid features and neuronal toxicity of mature prion fibrils are highly sensitive to high pressure. J Biol Chem (2011) 0.85
Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. J Biol Chem (2011) 0.85
Crystal structure of the cataract-causing P23T γD-crystallin mutant. Proteins (2013) 0.80
Proteomic analysis of protein plugs: causative agent of symptoms in patients with choledochal cyst. Dig Dis Sci (2007) 0.77
Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87
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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol (2008) 5.32
Simultaneous determination of protein structure and dynamics. Nature (2005) 5.28
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J Mol Med (Berl) (2003) 5.15
Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature (2003) 4.98
The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08
Long-range interactions within a nonnative protein. Science (2002) 4.06
Protein structure determination from NMR chemical shifts. Proc Natl Acad Sci U S A (2007) 3.96
An analytical solution to the kinetics of breakable filament assembly. Science (2009) 3.87
Amyloid formation by globular proteins under native conditions. Nat Chem Biol (2009) 3.72
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2004) 3.58
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell (2012) 3.39
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J Mol Biol (2005) 3.18
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. J Am Chem Soc (2005) 3.13
Role of intermolecular forces in defining material properties of protein nanofibrils. Science (2007) 2.94
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proc Natl Acad Sci U S A (2013) 2.89
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR. Nature (2004) 2.84
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am J Pathol (2003) 2.72
The importance of sequence diversity in the aggregation and evolution of proteins. Nature (2005) 2.70
High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. J Mol Biol (2007) 2.67
De novo designed peptide-based amyloid fibrils. Proc Natl Acad Sci U S A (2002) 2.59
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J (2002) 2.59
Prediction of aggregation-prone regions in structured proteins. J Mol Biol (2008) 2.56
A causative link between the structure of aberrant protein oligomers and their toxicity. Nat Chem Biol (2010) 2.48
Characterization of the nanoscale properties of individual amyloid fibrils. Proc Natl Acad Sci U S A (2006) 2.46
Molecular recycling within amyloid fibrils. Nature (2005) 2.39
Kinetic partitioning of protein folding and aggregation. Nat Struct Biol (2002) 2.37
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci (2004) 2.31
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril. Proc Natl Acad Sci U S A (2002) 2.18
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. J Mol Biol (2009) 2.14
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol (2004) 2.14
Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity (2005) 2.08
Urine in clinical proteomics. Mol Cell Proteomics (2008) 2.05
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A (2012) 1.99
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci (2004) 1.93
Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments. Proc Natl Acad Sci U S A (2003) 1.93
DNA-methylation analysis by the bisulfite-assisted genomic sequencing method. Methods Mol Biol (2002) 1.91
Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A (2008) 1.89
Prefibrillar amyloid aggregates could be generic toxins in higher organisms. J Neurosci (2006) 1.89
Life on the edge: a link between gene expression levels and aggregation rates of human proteins. Trends Biochem Sci (2007) 1.88
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A (2005) 1.88
Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. J Mol Biol (2008) 1.86
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
The splicing ATPase prp43p is a component of multiple preribosomal particles. Mol Cell Biol (2005) 1.82
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J Lipid Res (2010) 1.82
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases. Proc Natl Acad Sci U S A (2002) 1.80
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J (2007) 1.79
Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem (2004) 1.79
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet (2006) 1.77
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation. Protein Sci (2005) 1.74
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proc Natl Acad Sci U S A (2010) 1.72
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Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS Comput Biol (2007) 1.71
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci U S A (2007) 1.68
Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep (2008) 1.68
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature (2003) 1.66
Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme. Nat Struct Biol (2002) 1.64
Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation. Structure (2005) 1.63
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. Nat Struct Mol Biol (2011) 1.62
Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A (2009) 1.61
Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med (2010) 1.59
Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers. Cell Cycle (2009) 1.57
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence. Proc Natl Acad Sci U S A (2008) 1.56
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. J Mol Biol (2013) 1.56
Exploring amyloid formation by a de novo design. Proc Natl Acad Sci U S A (2004) 1.55
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. J Am Chem Soc (2011) 1.54
Metastability of native proteins and the phenomenon of amyloid formation. J Am Chem Soc (2011) 1.53
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Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb. EMBO J (2007) 1.52
Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status. Leuk Res (2009) 1.52
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry (2010) 1.50
ANS binding reveals common features of cytotoxic amyloid species. ACS Chem Biol (2010) 1.48
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem (2005) 1.48
Determination of a transition state at atomic resolution from protein engineering data. J Mol Biol (2002) 1.47
Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol (2004) 1.45
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure (2008) 1.45
Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein. J Am Chem Soc (2004) 1.44
Observation of sequence specificity in the seeding of protein amyloid fibrils. Protein Sci (2004) 1.44
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci U S A (2010) 1.42
Extensive analysis of the cytoplasmic proteome of human erythrocytes using the peptide ligand library technology and advanced mass spectrometry. Mol Cell Proteomics (2008) 1.41
Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils. J Mol Biol (2007) 1.39
Raft lipids as common components of human extracellular amyloid fibrils. Proc Natl Acad Sci U S A (2005) 1.38
In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging. J Am Chem Soc (2011) 1.37
Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation. J Immunol (2006) 1.36
The formation of spherulites by amyloid fibrils of bovine insulin. Proc Natl Acad Sci U S A (2004) 1.36
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J (2002) 1.35
Protein misfolding and disease: from the test tube to the organism. Curr Opin Chem Biol (2008) 1.35
The endo-beta-agarases AgaA and AgaB from the marine bacterium Zobellia galactanivorans: two paralogue enzymes with different molecular organizations and catalytic behaviours. Biochem J (2005) 1.34
Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies. Acta Neuropathol (2010) 1.34
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiol Aging (2010) 1.32
Proteomics of loosely bound cell wall proteins of Arabidopsis thaliana cell suspension cultures: a critical analysis. Electrophoresis (2003) 1.31
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. Proc Natl Acad Sci U S A (2005) 1.31
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proc Natl Acad Sci U S A (2004) 1.31
Structural biology. Dynamic visions of enzymatic reactions. Science (2006) 1.30
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy. Proc Natl Acad Sci U S A (2007) 1.30
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proc Natl Acad Sci U S A (2002) 1.30