Published in Nature on July 29, 2004
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An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Nat Struct Mol Biol (2009) 1.43
Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution. Proc Natl Acad Sci U S A (2007) 1.39
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Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc Natl Acad Sci U S A (2011) 1.25
Extensive backbone dynamics in the GCAA RNA tetraloop analyzed using 13C NMR spin relaxation and specific isotope labeling. J Am Chem Soc (2008) 1.24
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Protein vivisection reveals elusive intermediates in folding. J Mol Biol (2010) 1.06
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Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization. Proc Natl Acad Sci U S A (2009) 1.04
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Methods for calculating the entropy and free energy and their application to problems involving protein flexibility and ligand binding. Curr Protein Pept Sci (2009) 0.95
Observation of sequential steps in the folding of intestinal fatty acid binding protein using a slow folding mutant and 19F NMR. Proc Natl Acad Sci U S A (2007) 0.95
Protein folding: independent unrelated pathways or predetermined pathway with optional errors. Proc Natl Acad Sci U S A (2008) 0.94
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Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy. Nat Protoc (2009) 0.93
Probing microsecond time scale dynamics in proteins by methyl (1)H Carr-Purcell-Meiboom-Gill relaxation dispersion NMR measurements. Application to activation of the signaling protein NtrC(r). J Am Chem Soc (2010) 0.93
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Quantifying millisecond time-scale exchange in proteins by CPMG relaxation dispersion NMR spectroscopy of side-chain carbonyl groups. J Biomol NMR (2011) 0.90
The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. Biochemistry (2010) 0.90
The inverted chevron plot measured by NMR relaxation reveals a native-like unfolding intermediate in acyl-CoA binding protein. Proc Natl Acad Sci U S A (2006) 0.90
Sparsely populated folding intermediates of the Fyn SH3 domain: matching native-centric essential dynamics and experiment. Proc Natl Acad Sci U S A (2004) 0.90
Intermediate rate atomic trajectories of RNA by solid-state NMR spectroscopy. J Am Chem Soc (2010) 0.89
Entropy and free energy of a mobile protein loop in explicit water. J Phys Chem B (2008) 0.89
CPMG relaxation dispersion NMR experiments measuring glycine 1H alpha and 13C alpha chemical shifts in the 'invisible' excited states of proteins. J Biomol NMR (2009) 0.89
A 2D ¹³C-CEST experiment for studying slowly exchanging protein systems using methyl probes: an application to protein folding. J Biomol NMR (2012) 0.88
A new amide proton R1rho experiment permits accurate characterization of microsecond time-scale conformational exchange. J Biomol NMR (2005) 0.88
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proc Natl Acad Sci U S A (2008) 0.88
Protein folding on the ribosome studied using NMR spectroscopy. Prog Nucl Magn Reson Spectrosc (2013) 0.87
Evidence against the "Y-T coupling" mechanism of activation in the response regulator NtrC. J Mol Biol (2014) 0.87
Constrained proper sampling of conformations of transition state ensemble of protein folding. J Chem Phys (2011) 0.87
Probing slowly exchanging protein systems via ¹³Cα-CEST: monitoring folding of the Im7 protein. J Biomol NMR (2013) 0.87
Solution NMR Spectroscopy for the Study of Enzyme Allostery. Chem Rev (2016) 0.87
Characterization of a transient unfolding intermediate in a core mutant of γS-crystallin. J Mol Biol (2010) 0.87
Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study. J Am Chem Soc (2011) 0.87
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Assessment of the effects of increased relaxation dispersion data on the extraction of 3-site exchange parameters characterizing the unfolding of an SH3 domain. J Biomol NMR (2006) 0.87
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Off-resonance rotating-frame amide proton spin relaxation experiments measuring microsecond chemical exchange in proteins. J Biomol NMR (2005) 0.85
"Invisible" conformers of an antifungal disulfide protein revealed by constrained cold and heat unfolding, CEST-NMR experiments, and molecular dynamics calculations. Chemistry (2015) 0.85
Cold denaturation of a protein dimer monitored at atomic resolution. Nat Chem Biol (2013) 0.84
An R(1ρ) expression for a spin in chemical exchange between two sites with unequal transverse relaxation rates. J Biomol NMR (2013) 0.84
Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. Biochemistry (2010) 0.84
Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen. Biophys J (2014) 0.84
Quantitative analysis of backbone motion in proteins using MAS solid-state NMR spectroscopy. J Biomol NMR (2009) 0.84
Observation of microsecond time-scale protein dynamics in the presence of Ln3+ ions: application to the N-terminal domain of cardiac troponin C. J Biomol NMR (2006) 0.83
An exact solution for R2,eff in CPMG experiments in the case of two site chemical exchange. J Magn Reson (2014) 0.83
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Native state dynamics drive the unfolding of the SH3 domain of PI3 kinase at high denaturant concentration. Proc Natl Acad Sci U S A (2009) 0.83
Insights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free water. PLoS One (2009) 0.83
Binding kinetics of histone chaperone Chz1 and variant histone H2A.Z-H2B by relaxation dispersion NMR spectroscopy. J Mol Biol (2009) 0.83
Noise and functional protein dynamics. Biophys J (2005) 0.83
Internal protein dynamics on ps to μs timescales as studied by multi-frequency (15)N solid-state NMR relaxation. J Biomol NMR (2013) 0.83
Strong coupling effects during X-pulse CPMG experiments recorded on heteronuclear ABX spin systems: artifacts and a simple solution. J Biomol NMR (2007) 0.82
Measurement of signs of chemical shift differences between ground and excited protein states: a comparison between H(S/M)QC and R1rho methods. J Biomol NMR (2009) 0.82
Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations. Nucleic Acids Res (2015) 0.81
A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis. Elife (2015) 0.81
The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements. J Biomol NMR (2011) 0.81
Domain-domain motions in proteins from time-modulated pseudocontact shifts. J Biomol NMR (2007) 0.80
Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87
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The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08
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The phage lambda major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system. Proc Natl Acad Sci U S A (2009) 3.03
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Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science (2005) 2.47
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