PubRank

A Kazlauskas

Author PubWeight™ 113.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995 11.86
2 Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 1999 4.97
3 Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 1993 4.83
4 PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 1994 4.67
5 c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev 1999 3.09
6 Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J 1992 2.79
7 Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature 1994 2.71
8 Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science 1994 2.65
9 The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science 1992 2.41
10 EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J 1996 2.11
11 Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J Biol Chem 1995 2.06
12 SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol 1992 2.00
13 Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol 2001 1.99
14 Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol 1993 1.88
15 Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol 1996 1.68
16 Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem 2000 1.62
17 Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation. J Biol Chem 1991 1.57
18 Identification of a putative Syp substrate, the PDGF beta receptor. J Biol Chem 1995 1.55
19 Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1999 1.49
20 Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors 1999 1.43
21 Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem 1998 1.40
22 Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol Cell Biol 1995 1.38
23 Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells. Mol Cell Biol 1990 1.38
24 Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res 1999 1.37
25 Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 1996 1.35
26 PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol 1999 1.31
27 Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. J Biol Chem 1998 1.31
28 A role for Src in signal relay by the platelet-derived growth factor alpha receptor. J Biol Chem 1998 1.28
29 Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J Biol Chem 1999 1.16
30 Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol 1995 1.15
31 Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol Cell Biol 1998 1.14
32 Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. J Biol Chem 1999 1.14
33 Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Am J Pathol 2000 1.13
34 A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells. Mol Biol Cell 1999 1.13
35 Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Curr Biol 1998 1.13
36 Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL. Am J Transplant 2007 1.12
37 Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Invest Ophthalmol Vis Sci 2000 1.11
38 The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1. Mol Cell Biol 1995 1.10
39 D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor. Biochem J 1996 1.06
40 Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene 1994 1.06
41 The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways. Blood 2001 1.06
42 Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase. J Biol Chem 1997 1.05
43 Growth factor-dependent signaling and cell cycle progression. FEBS Lett 2001 1.05
44 Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1999 1.02
45 Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol Cell Biol 1996 0.98
46 Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases. Cell Growth Differ 1991 0.97
47 PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Curr Biol 2000 0.95
48 Cultured endothelial cells do not respond to a platelet-derived growth-factor-like protein in an autocrine manner. Biochim Biophys Acta 1985 0.94
49 Platelet-derived growth factor induces a long-term inhibition of N-methyl-D-aspartate receptor function. J Biol Chem 1996 0.93
50 Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage. Gene Ther 2011 0.92
51 Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Biochem Biophys Res Commun 1997 0.91
52 Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma. FASEB J 1999 0.91
53 Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J Biol Chem 2000 0.91
54 The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP. Oncogene 1994 0.89
55 A new member of an old family. Nat Cell Biol 2000 0.88
56 Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor. J Biol Chem 1994 0.88
57 Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways. J Biol Chem 1999 0.86
58 Platelet-derived growth factor receptor is a novel modulator of type A gamma-aminobutyric acid-gated ion channels. Mol Pharmacol 1995 0.86
59 Multiple roles for Src in a PDGF-stimulated cell. Exp Cell Res 1999 0.85
60 The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs. J Biol Chem 1997 0.84
61 Roles of platelet-derived growth factor in the developing and mature nervous systems. Brain Res Brain Res Rev 1997 0.84
62 Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. Exp Cell Res 1999 0.84
63 Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochem Biophys Res Commun 1996 0.83
64 PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene 1997 0.83
65 Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J 1999 0.82
66 [Viral vectors for gene delivery to corneal endothelial cells]. Klin Monbl Augenheilkd 2011 0.81
67 Growth factor-dependent signaling and cell cycle progression. Chem Rev 2001 0.81
68 Early phosphoinositide 3-kinase activity is required for late activation of protein kinase Cepsilon in platelet-derived-growth-factor-stimulated cells: evidence for signalling across a large temporal gap. Biochem J 2001 0.80
69 The kinase-inactive PDGF beta-receptor mediates activation of the MAP kinase cascade via the endogenous PDGF alpha-receptor in HepG2 cells. Oncogene 1996 0.79
70 Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene 2000 0.79
71 A comparison of the platelet-derived growth factor-dependent tyrosine kinase activity in sparse and confluent fibroblasts. J Cell Physiol 1986 0.79
72 Advances in a gene therapy-based approach to treat proliferative vitreoretinopathy. Arch Soc Esp Oftalmol 2003 0.78
73 A novel endoproteolytic processing activity in mitochondria of erythroid cells and the role in heme synthesis. Blood 2000 0.78
74 Comparison of the phosphorylation events in membranes from proliferating vs. quiescent endothelial cells. J Cell Physiol 1987 0.77
75 Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Mol Carcinog 1999 0.77
76 Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy. Diabetologia 2013 0.76
77 Expression of PDGF, VEGF and their receptors in non-small cell lung tumor cell lines. Int J Oncol 1996 0.75
78 The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. Exp Cell Res 2001 0.75
79 [Pathophysiologic significance of growth factors and new therapeutic concepts in cardiovascular disease]. Med Klin (Munich) 1999 0.75