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Top papers

Rank Title Journal Year PubWeight™‹?›
1 A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 1998 8.10
2 The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 2001 4.93
3 Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A 1999 4.84
4 Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997 4.20
5 Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem 1999 3.95
6 Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 2000 3.01
7 Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 2001 2.78
8 Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J 2000 2.74
9 Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A 1998 2.71
10 Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nat Genet 1998 2.44
11 Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A 1997 2.35
12 Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 1997 1.80
13 Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor. Mol Cell Biol 2001 1.58
14 Mutations in the insulin receptor gene. Endocr Rev 1992 1.55
15 Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol 1998 1.52
16 Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? Diabetes 1994 1.52
17 Regulation of pancreatic beta-cell function by the forkhead protein FoxO1. Diabetes Obes Metab 2007 1.47
18 Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. Science 1989 1.46
19 A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. J Clin Invest 1990 1.42
20 Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt. Biochemistry 2001 1.40
21 Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem 1998 1.38
22 Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors. J Clin Invest 1997 1.36
23 Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest 1998 1.34
24 Clinical review 125: The insulin receptor and its cellular targets. J Clin Endocrinol Metab 2001 1.31
25 Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene. J Clin Endocrinol Metab 1993 1.26
26 The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. J Clin Invest 1999 1.26
27 Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR. A mechanism for insulin inhibition of insulin-like growth factor-binding protein-1 transcription. J Biol Chem 2000 1.21
28 Galectin-8. A new rat lectin, related to galectin-4. J Biol Chem 1995 1.20
29 Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest 1991 1.18
30 Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1994 1.14
31 Genetic modifiers of the insulin resistance phenotype in mice. Diabetes 2000 1.14
32 Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabetes Obes Metab 2009 1.14
33 Glucose effects on skin keratinocytes: implications for diabetes skin complications. Diabetes 2001 1.13
34 Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J Biol Chem 1995 1.12
35 Mutations in insulin-receptor gene in insulin-resistant patients. Diabetes Care 1990 1.08
36 Syndromes of autoimmunity and hypoglycemia. Autoantibodies directed against insulin and its receptor. Endocrinol Metab Clin North Am 1989 1.07
37 The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells. J Clin Endocrinol Metab 2000 1.06
38 Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase. J Biol Chem 1995 1.06
39 Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. Proc Natl Acad Sci U S A 1987 1.04
40 The regulation of skin proliferation and differentiation in the IR null mouse: implications for skin complications of diabetes. Endocrinology 2001 1.04
41 Role of insulin receptors and IGF receptors in growth and development. Pediatr Nephrol 2000 1.01
42 Genetic basis of endocrine disease. 1. Molecular genetics of insulin resistant diabetes mellitus. J Clin Endocrinol Metab 1991 0.98
43 Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 1995 0.98
44 A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing. Diabetes 1994 0.94
45 pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. J Biol Chem 1993 0.94
46 Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. Biochem Biophys Res Commun 1991 0.92
47 Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Dev Neurosci 1998 0.91
48 Structural organization of the murine D3 dopamine receptor gene. J Neurochem 1995 0.91
49 What ails the β-cell? Diabetes Obes Metab 2010 0.90
50 Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia. Endocrinology 2000 0.90
51 Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor. J Biol Chem 1998 0.89
52 Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells. Biochim Biophys Acta 1993 0.89
53 Tissue distribution and subcellular localization of an endogenous substrate (pp 120) for the insulin receptor-associated tyrosine kinase. Endocrinology 1986 0.89
54 Mechanisms of hormone resistance: lessons from insulin-resistant patients. Acta Paediatr Suppl 1994 0.89
55 Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction. J Clin Endocrinol Metab 1990 0.89
56 Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism. Hum Mutat 1995 0.88
57 The mechanism of insulin action. J Pediatr Endocrinol Metab 1999 0.88
58 Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis. Diabetologia 1998 0.88
59 Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997 0.87
60 Differential signaling of insulin and IGF-1 receptors to glycogen synthesis in murine hepatocytes. Biochemistry 1999 0.87
61 Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding. J Biol Chem 1990 0.86
62 D3 dopamine receptor-deficient mouse: evidence for reduced anxiety. Physiol Behav 1997 0.85
63 Substitution of arginine for histidine at position 209 in the alpha-subunit of the human insulin receptor. A mutation that impairs receptor dimerization and transport of receptors to the cell surface. J Biol Chem 1991 0.84
64 Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice. Am J Physiol Endocrinol Metab 2001 0.84
65 Neurotensin gene expression and behavioral responses following administration of psychostimulants and antipsychotic drugs in dopamine D(3) receptor deficient mice. Neuropsychopharmacology 2001 0.83
66 Expression of kinase-inactive mutant insulin receptors does not rescue insulin receptor-deficient mice from perinatal death. Diabetologia 1999 0.82
67 Structural and functional analysis of the insulin receptor promoter. Mol Endocrinol 1990 0.81
68 Fine localization of sulphated and non-sulphated glycoconjugates in the rabbit oviduct during the estrous cycle. Acta Histochem 1984 0.81
69 Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene. J Clin Invest 1996 0.81
70 Glycoconjugates in the reproductive system of female rabbits in physiological estrogenic conditions. Anat Anz 1984 0.81
71 Expression of a cDNA encoding the human insulin receptor-related receptor. J Biol Chem 1994 0.80
72 Mutations of the human insulin receptor gene. Trends Endocrinol Metab 2008 0.79
73 Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells. Biochemistry 1996 0.79
74 Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance. J Med Genet 1994 0.79
75 Double-sided staining with a gold probe and silver enhancement to detect alpha-amylase and sugar moieties in the mouse salivary glands. Histol Histopathol 1999 0.79
76 Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes. J Cell Biochem 1997 0.79
77 Biochemical characterization of sialoglycoconjugates isolated from the submandibular glands of growing and adult cats. Cell Mol Biol 1986 0.79
78 Identification of muramyl derivatives in Mollusca Gastropoda tissue. Histochemistry 1991 0.79
79 Extraction and characterization of glycoconjugate components in the submandibular gland of hares. Cell Mol Biol 1984 0.79
80 Long in the shade, glucagon re-occupies centre court. Diabetes Obes Metab 2011 0.79
81 The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver. Diabetes 2000 0.78
82 Decreased expression of insulin-sensitive glucose transporter mRNA (GLUT-4) in adipose tissue of non-insulin-dependent diabetic and obese patients: evaluation by a simplified quantitative PCR assay. J Endocrinol Invest 1994 0.78
83 Lectins as indicators of cell surface and cytoplasmic sugar changes in the oviduct of the postovulatory and pregnant rabbit. Basic Appl Histochem 1986 0.78
84 Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice. Ann Med 2001 0.78
85 Mosaic lectin labelling in the quail collecting ducts. Histol Histopathol 1995 0.77
86 Characterisation in situ of the complex carbohydrates in rabbit oviduct using digestion with glycosidases followed by lectin binding. J Anat 1985 0.77
87 Deletion of exon 3 of the insulin receptor gene in a kindred with a familial form of insulin resistance. J Clin Endocrinol Metab 1994 0.77
88 Transgenic mice to study the role of dopamine receptors in cardiovascular function. Clin Exp Hypertens 1997 0.77
89 Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN. J Biol Chem 1998 0.77
90 A new look at dopamine D3 receptors. Mol Psychiatry 1996 0.76
91 Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor. EMBO J 1994 0.76
92 Ultrastructure and complex carbohydrate ultracytochemistry of the cat parotid gland. Biol Struct Morphog 1989 0.76
93 Role of the exon 11 of the insulin receptor gene on insulin binding identified by anti-peptide antibodies. Mol Cell Endocrinol 1994 0.76
94 Shifting the paradigm of islet inflammation--good guy or bad guy? Diabetes Obes Metab 2013 0.75
95 Ultracytochemical detection of heteropolysaccharides in the cat submandibular gland. J Anat 1987 0.75
96 Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance. Adv Exp Med Biol 1991 0.75
97 Preliminary researches on the characterization of the glycoconjugates in the oviduct of Rana esculenta complex during its reproductive cycle. Anat Anz 1985 0.75
98 Confocal evaluation of native and induced lectin binding contributes to discriminate between lingual gland glycocomponents in quail. Histol Histopathol 2000 0.75
99 Quantitative evaluation of carbohydrate components present in lagomorph oviducts. Anat Anz 1989 0.75
100 Carbohydrate components of hare oviduct studied by histochemical and biochemical techniques. Basic Appl Histochem 1988 0.75
101 Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382. J Biol Chem 1993 0.75
102 Enzymatic degradation and quantitative lectin labeling for characterizing glycoconjugates which act as lectin acceptors in cat submandibular gland. Histochemistry 1989 0.75
103 Estrogen-induced changes on the oviduct glycoconjugates in hypophysectomized and/or ovariectomized frogs. Cell Mol Biol 1987 0.75
104 Effects of hypophysectomy and hormonal substances on the carbohydrate components of the oviduct of the Rana esculenta complex. Cell Mol Biol 1986 0.75
105 Unusual forms of insulin resistance. Annu Rev Med 1991 0.75
106 The effect of lysine acetylsalicylate on somatostatin inhibition of insulin secretion induced by arginine. Exp Clin Endocrinol 1986 0.75
107 Sublingual gland of the hare (Lepus europaeus): ultrastructural aspects and carbohydrate histochemistry. Cell Mol Biol 1985 0.75
108 Protein phosphorylation and insulin action. Adv Exp Med Biol 1988 0.75
109 Sialoglycoderivatives of bovine submandibular gland identified in situ by histochemical techniques combined with lectins. Histochemistry 1992 0.75
110 Retraction: Turning up the heat in the fat cell. Nat Med 2005 0.75
111 A conserved region in the first intron of the insulin receptor gene binds nuclear proteins during adipocyte differentiation. Biochem Biophys Res Commun 1997 0.75
112 Mutations in the insulin receptor gene in genetic forms of insulin resistance. Recent Prog Horm Res 1990 0.75
113 Characterization of glycoconjugates in an embryonic human epithelial line and changes consequent to adaptation to a hyperosmotic medium. Histochem J 1989 0.75
114 Differential binding sites of peroxidase-labelled lectins in the submandibular gland of sucking and adult cats. Acta Histochem 1987 0.75
115 Molecular cloning of pp120/ECTO-ATPase, an endogenous substrate of the insulin receptor kinase. Adv Exp Med Biol 1993 0.75
116 Glycosidic residues in the mouse submandibular gland: biochemical determination and visualization with plant lectins. Basic Appl Histochem 1986 0.75
117 Distribution and evaluation of complex carbohydrates in the quail collecting ducts. Acta Histochem 1995 0.75
118 Influence of fixation on the lectin binding sites in the rabbit salivary glands. Acta Histochem 1985 0.75
119 Thrombosis, recurrent abortions and intrauterine foetal death in a patient with lupus anticoagulant. Clin Rheumatol 1985 0.75
120 Attempt to visualize an endogenous lectin recognizing alpha-L-fucose immunohistochemically in the rabbit oviduct. Acta Histochem 1989 0.75
121 Visualization of carbohydrate chains in rabbit salivary glands by means of enzymatic degradation and plant lectins. Acta Histochem 1988 0.75
122 Mitogenic and metabolic effects of type I IGF receptor overexpression in insulin receptor-deficient hepatocytes. Endocrinology 2001 0.75
123 Determination in situ of neutral and acidic fucose-containing oligosaccharides in the bovine submandibular gland. Histochemistry 1993 0.75
124 New perspectives in diabetes research and treatment. Trends Endocrinol Metab 2000 0.75