Published in Endocr Rev on August 01, 1992
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J Clin Invest (2009) 2.53
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. J Clin Invest (2008) 2.36
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22
Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Natl Acad Sci U S A (1999) 1.68
Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation. Eur J Pediatr (2012) 1.48
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia (1994) 1.47
Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor. Genetics (2008) 1.38
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest (1995) 1.32
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A (1994) 1.29
The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. J Clin Invest (1999) 1.26
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes (2011) 1.05
Genetics of the polycystic ovary syndrome. Mol Cell Endocrinol (2012) 0.97
Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again. J Clin Invest (2004) 0.97
Insulin receptor activation with transmembrane domain ligands. J Biol Chem (2014) 0.94
Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients. J Clin Invest (1998) 0.93
Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats. Biochem J (1994) 0.91
State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS). Int J Pediatr Endocrinol (2011) 0.90
Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent. Mol Cell Biol (1994) 0.88
Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance. J Clin Invest (1998) 0.86
Association of the insulin-receptor variant Met-985 with hyperglycemia and non-insulin-dependent diabetes mellitus in the Netherlands: a population-based study. Am J Hum Genet (1996) 0.85
Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells. Diabetes (2014) 0.84
Signalling through the insulin receptor and the insulin-like growth factor-I receptor. Diabetologia (1994) 0.83
The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia. J Clin Res Pediatr Endocrinol (2015) 0.83
Perspectives in Polycystic Ovary Syndrome: From Hair to Eternity. J Clin Endocrinol Metab (2016) 0.81
RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family. Hum Mutat (2007) 0.81
Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene. J Clin Invest (1996) 0.81
Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey. J Clin Invest (1994) 0.79
Obesity and cancer, a case for insulin signaling. Cell Death Dis (2015) 0.79
Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance. J Med Genet (1994) 0.79
Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling. Diabetologia (2011) 0.77
Lifespan and glucose metabolism in insulin receptor mutant mice. J Aging Res (2011) 0.77
Successful pregnancy outcomes in a patient with type A insulin resistance syndrome. Diabet Med (2015) 0.77
Pathophysiology of non-insulin-dependent diabetes and the search for candidate genes: dangerous liaisons? Acta Diabetol (1996) 0.76
Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies. G3 (Bethesda) (2016) 0.76
Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor. EMBO J (1994) 0.76
Loss of NPC1 function in a patient with a co-inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance. J Inherit Metab Dis (2010) 0.76
SNP analysis of follistatin gene associated with polycystic ovarian syndrome. Adv Appl Bioinform Chem (2010) 0.75
Reducing IRS-1 Activation Cause Mutation of Tyrosine Kinase Domain hINSR Gene on Type-2 Diabetes Mellitus Patients. Bioinformation (2013) 0.75
Insulin receptor gene expression and insulin resistance. J Endocrinol Invest (1995) 0.75
Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics (1989) 19.10
Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab (2000) 11.97
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10
A precise and fast temperature mapping using water proton chemical shift. Magn Reson Med (1995) 5.73
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest (2001) 4.93
Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses. Virology (1991) 4.85
Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A (1999) 4.84
Genetic analysis of blood pressure in spontaneously hypertensive rats. Jpn Circ J (1970) 4.59
Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'. Nature (1965) 4.53
Glycogen and adipose tissue. J Physiol (1942) 4.42
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem (1999) 3.95
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A (1995) 3.85
Large voltage-induced magnetic anisotropy change in a few atomic layers of iron. Nat Nanotechnol (2009) 3.75
The DNA sequence of Bombyx mori fibroin gene including the 5' flanking, mRNA coding, entire intervening and fibroin protein coding regions. Cell (1979) 3.60
Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res (2001) 3.51
Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer. Hepatology (2000) 3.42
Mini-laparoscopic appendectomy using a needle loop retractor offers optimal cosmetic results. Surg Endosc (2004) 3.38
The in vitro synthesis of glycogen in the diaphragms of normal and alloxan-diabetic rats. Biochem J (1948) 3.25
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries. Science (2001) 3.21
Structural analysis of the fibroin gene at the 5' end and its surrounding regions. Cell (1979) 3.16
Accelerated transport and maturation of lysosomal alpha-galactosidase A in Fabry lymphoblasts by an enzyme inhibitor. Nat Med (1999) 3.11
Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species. Virology (1997) 3.10
Evolutionary motif and its biological and structural significance. J Mol Evol (1997) 3.03
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
A new malformation syndrome of long palpebral fissures, large ears, depressed nasal tip, and skeletal anomalies associated with postnatal dwarfism and mental retardation. J Pediatr (1981) 2.97
Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J Exp Med (1996) 2.97
Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol (1998) 2.97
Complete nucleotide sequence and genetic organization of Aichi virus, a distinct member of the Picornaviridae associated with acute gastroenteritis in humans. J Virol (1998) 2.85
Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest (1996) 2.82
Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev (2001) 2.78
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A (1998) 2.71
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell (2000) 2.69
Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology (1998) 2.67
A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Science (1992) 2.63
Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res (1987) 2.59
Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation (2000) 2.59
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Globoid cell leucodystrophy (Krabbe's disease): deficiency of galactocerebroside beta-galactosidase. Proc Natl Acad Sci U S A (1970) 2.48
Phage particle-mediated gene transfer to cultured mammalian cells. Mol Cell Biol (1982) 2.47
Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. J Biol Chem (2001) 2.45
Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome. Neurology (2008) 2.45
Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nat Genet (1998) 2.44
On the behaviour of glycogen after diets rich in protein and in carbohydrate. J Physiol (1938) 2.44
Faithful transcription initiation of fibroin gene in a homologous cell-free system reveals an enhancing effect of 5' flanking sequence far upstream. Cell (1981) 2.42
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem (2001) 2.42
Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action. J Biol Chem (1993) 2.41
Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection. J Virol (1997) 2.38
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care (1995) 2.33
Organization of rRNA genes in Mycobacterium bovis BCG. J Bacteriol (1987) 2.33
The enzymatic acetylation of chloramphenicol by the multiple drug-resistant Escherichia coli carrying R factor. J Biol Chem (1967) 2.31
The genes for silk fibroin in Bombyx mori. J Mol Biol (1972) 2.29
Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol (1998) 2.21
Application of a reverse transcription-PCR for identification and differentiation of Aichi virus, a new member of the Picornavirus family associated with gastroenteritis in humans. J Clin Microbiol (2000) 2.19
Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction. Circulation (1999) 2.19
Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B. Chest (1998) 2.18
Heptakis(2,6-O-dimethyl)beta-cyclodextrin: a novel growth stimulant for Bordetella pertussis phase I. J Clin Microbiol (1983) 2.17
Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). Mutagenesis (1999) 2.16
Pulmonary fibrosis in asbestos insulation workers with lung cancer: a radiological and histopathological evaluation. Br J Ind Med (1987) 2.14
Phase III study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemia. Leukemia (2004) 2.08
Effect of heptakis (2,6-O-dimethyl) beta-cyclodextrin on the production of pertussis toxin by Bordetella pertussis. Infect Immun (1983) 2.06
Is white coat hypertension innocent? Structure and function of the heart in the elderly. Hypertension (1993) 1.99
The genetic abnormality in the beta cell determines the response to an oral glucose load. Diabetologia (2002) 1.99
Incidence of primary cholangiocellular carcinoma of the liver in japanese patients with hepatitis C virus-related cirrhosis. Cancer (2000) 1.98
Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients. Eur J Cancer (1999) 1.94
Promoter sequence of fibroin gene assigned by in vitro transcription system. Proc Natl Acad Sci U S A (1981) 1.87
Segmental spinal dysgenesis: neuroradiologic findings with clinical and embryologic correlation. AJNR Am J Neuroradiol (1999) 1.86
Permanent diabetes mellitus in the first year of life. Diabetologia (2002) 1.84
Comet 81P/Wild 2 under a microscope. Science (2006) 1.83
Stevens-Johnson syndrome induced by methazolamide treatment. Arch Ophthalmol (1997) 1.83
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol (1997) 1.80
The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway. Proc Natl Acad Sci U S A (1996) 1.80
Basis of chloramphenicol resistance in naturally isolated resistant staphylococci. J Bacteriol (1966) 1.80
Isolation and identification of the messenger RNA for silk fibroin from Bombyx mori. J Mol Biol (1972) 1.79
Neonatal diabetes mellitus due to complete glucokinase deficiency. N Engl J Med (2001) 1.78
Amino acid residues contributing to the substrate specificity of the influenza A virus neuraminidase. J Virol (1999) 1.78
Mucopolysaccharidosis type IVA (Morquio A disease): clinical review and current treatment. Curr Pharm Biotechnol (2011) 1.78
Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg (1992) 1.77
Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol (1999) 1.77
Activation of calmodulin by various metal cations as a function of ionic radius. Mol Pharmacol (1984) 1.77
Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem (1999) 1.77
Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Oncogene (1999) 1.76
Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: the existence of genes possibly involved in chloroplast division. Proc Natl Acad Sci U S A (1997) 1.75
Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J Immunol (2000) 1.75
CART classification of human 5' UTR sequences. Genome Res (2000) 1.75
Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proc Natl Acad Sci U S A (1999) 1.75
A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis. Gut (2006) 1.75
Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells. Kidney Int (2007) 1.74
Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells. Hepatology (1997) 1.74
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. J Pathol (1995) 1.74
Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor. Proc Natl Acad Sci U S A (1990) 1.74
Establishment of pure NOTES procedure using a conventional flexible endoscope: review of six cases of gastric gastrointestinal stromal tumors. Endoscopy (2011) 1.73
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. Proc Natl Acad Sci U S A (1987) 1.72
Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases. Am J Hum Genet (1991) 1.72
Role of the renin-angiotensin system in vascular diseases: expanding the field. Hypertension (2001) 1.72