Published in J Biol Chem on June 04, 1999
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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 5.78
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J (2000) 5.30
Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol (2000) 5.22
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest (2001) 4.93
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Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res (2014) 1.27
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Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol (2013) 1.24
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J (2010) 1.24
FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem (2009) 1.19
Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia (2010) 1.19
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CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem (2008) 1.16
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Clever cancer strategies with FoxO transcription factors. Cell Cycle (2008) 1.05
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Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci (2012) 1.04
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Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis. Nucleic Acids Res (2012) 0.98
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A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem (2009) 0.96
Regulation of transcription factor activity by interconnected post-translational modifications. Trends Pharmacol Sci (2013) 0.95
Regulation of Ras signaling specificity by protein kinase C. Mol Cell Biol (2001) 0.95
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochem J (2005) 0.94
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Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta (2009) 0.94
Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY) (2012) 0.93
Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization. J Clin Invest (2000) 0.93
A fork in the path: Developing therapeutic inroads with FoxO proteins. Oxid Med Cell Longev (2010) 0.92
Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells. Cell Cycle (2013) 0.92
Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells. Am J Physiol Cell Physiol (2008) 0.92
beta1-Integrin-collagen interaction suppresses FoxO3a by the coordination of Akt and PP2A. J Biol Chem (2010) 0.91
Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem (2013) 0.91
Klotho regulates retinal pigment epithelial functions and protects against oxidative stress. J Neurosci (2013) 0.91
Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J Neurochem (2012) 0.90
Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology. ScientificWorldJournal (2009) 0.90
Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene. J Biol Chem (2012) 0.90
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Adv Enzyme Regul (2008) 0.89
Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Am J Pathol (2009) 0.88
FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival. Mol Endocrinol (2012) 0.88
Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis. PLoS One (2012) 0.87
Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort. BMC Med Genet (2014) 0.87
FoxO1 gain of function in the pancreas causes glucose intolerance, polycystic pancreas, and islet hypervascularization. PLoS One (2012) 0.86
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