Published in Nature on May 14, 1992
Toward a molecular definition of long-term memory storage. Proc Natl Acad Sci U S A (1996) 2.81
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci U S A (2002) 2.57
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci (2006) 1.94
Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci (2008) 1.84
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J (2004) 1.54
Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft. Biophys J (1997) 1.38
Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS One (2010) 1.26
Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation. Philos Trans R Soc Lond B Biol Sci (2003) 1.25
Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn. J Physiol (1998) 1.16
Postsynaptic expression of long-term potentiation in the rat dentate gyrus demonstrated by variance-mean analysis. J Physiol (1999) 1.09
Novel expression mechanism for synaptic potentiation: alignment of presynaptic release site and postsynaptic receptor. Proc Natl Acad Sci U S A (1997) 1.08
Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture. J Physiol (1997) 1.05
Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol (2006) 1.02
Presynaptic modulation of cortical synaptic activity by calcineurin. Proc Natl Acad Sci U S A (1995) 0.99
Properties of fast endocytosis at hippocampal synapses. Philos Trans R Soc Lond B Biol Sci (1999) 0.98
A GFP-based system to uncouple mRNA transport from translation in a single living neuron. Mol Biol Cell (2003) 0.96
Effects of variance in mini amplitude on stimulus-evoked release: a comparison of two models. Biophys J (1996) 0.96
Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice. Neuropharmacology (2009) 0.95
Activity-dependent augmentation of spontaneous neurotransmission during endoplasmic reticulum stress. J Neurosci (2010) 0.95
Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1. Proc Natl Acad Sci U S A (2010) 0.93
H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. Pflugers Arch (2009) 0.93
Protein fingerprints of cultured CA3-CA1 hippocampal neurons: comparative analysis of the distribution of synaptosomal and cytosolic proteins. BMC Neurosci (2008) 0.91
Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2. Proc Natl Acad Sci U S A (2013) 0.90
Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression. J Neurochem (2006) 0.90
Ca2+/calmodulin-dependent protein kinase II phosphorylation of the presynaptic protein synapsin I is persistently increased during long-term potentiation. Proc Natl Acad Sci U S A (1996) 0.89
Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proc Natl Acad Sci U S A (1996) 0.89
Spatial changes in calcium signaling during the establishment of neuronal polarity and synaptogenesis. J Cell Biol (1994) 0.88
Rapid and long-lasting increase in sites for synapse assembly during late-phase potentiation in rat hippocampal neurons. PLoS One (2009) 0.87
Presynaptic ultrastructural plasticity along CA3→CA1 axons during long-term potentiation in mature hippocampus. J Comp Neurol (2013) 0.87
Early presynaptic changes during plasticity in cultured hippocampal neurons. EMBO J (2006) 0.87
Roles of Na(+)-Ca2+ exchange and of mitochondria in the regulation of presynaptic Ca2+ and spontaneous glutamate release. Philos Trans R Soc Lond B Biol Sci (1999) 0.87
Muscarinic stimulation of synaptic activity by protein kinase C is inhibited by adenosine in cultured hippocampal neurons. Proc Natl Acad Sci U S A (1997) 0.86
The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. J Biol Chem (2010) 0.86
Distribution of RGS9-2 in neurons of the mouse striatum. J Neurochem (2009) 0.85
A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. Br J Pharmacol (2000) 0.84
Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neurons. Learn Mem (2006) 0.83
A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci (2009) 0.82
Zinc potentiation of neurotransmission and inhibition of background cationic conductance in rat cultured hippocampal neurones. J Physiol (1995) 0.81
Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proc Natl Acad Sci U S A (1994) 0.79
Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current. Philos Trans R Soc Lond B Biol Sci (2013) 0.78
Optogenetic Control of Synaptic Composition and Function. Neuron (2017) 0.78
Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP. Elife (2016) 0.76
A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP. Front Cell Neurosci (2015) 0.76
Rapid genotyping of animals followed by establishing primary cultures of brain neurons. J Vis Exp (2015) 0.75
Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways. Front Cell Neurosci (2016) 0.75
Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease. Sci Rep (2016) 0.75
DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep (2017) 0.75
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature (1984) 10.27
Mechanism of ion permeation through calcium channels. Nature (1984) 9.82
Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature (1985) 9.68
The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres. J Physiol (1968) 7.88
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. J Gen Physiol (1986) 6.76
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol (1987) 6.72
Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J Physiol (1969) 6.59
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature (1987) 5.94
Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature (1983) 5.80
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol (1986) 5.38
Calcium channels in excitable cell membranes. Annu Rev Physiol (1983) 5.37
Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature (1999) 5.36
A novel type of cardiac calcium channel in ventricular cells. Nature (1985) 5.33
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature (1993) 5.31
Lidocaine block of cardiac sodium channels. J Gen Physiol (1983) 5.13
Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci (1988) 5.12
Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol (1978) 4.72
Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol (1985) 4.69
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science (1989) 4.48
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science (1994) 4.38
Reconstruction of the electrical activity of cardiac Purkinje fibres. J Physiol (1975) 4.31
CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell (1996) 4.08
Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature (1990) 4.05
Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science (1988) 3.75
Calcium channels: mechanisms of selectivity, permeation, and block. Annu Rev Biophys Biophys Chem (1987) 3.72
Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (1987) 3.69
Single synaptic vesicles fusing transiently and successively without loss of identity. Nature (2003) 3.51
The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron (1993) 3.49
Reversal of current through calcium channels in dialysed single heart cells. Nature (1982) 3.43
Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron (1995) 3.39
Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol (1986) 3.31
Properties of single calcium channels in cardiac cell culture. Nature (1982) 3.30
Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron (1999) 3.29
Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature (1984) 3.24
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature (1999) 3.21
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature (1998) 3.13
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc Natl Acad Sci U S A (1987) 3.12
High selectivity of calcium channels in single dialysed heart cells of the guinea-pig. J Physiol (1984) 3.12
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci (1995) 3.07
Calcium-activated transient outward current in calf cardiac Purkinje fibres. J Physiol (1980) 2.95
Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol (1978) 2.94
Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron (1996) 2.86
Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. Nat New Biol (1972) 2.84
A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i. J Physiol (1992) 2.83
Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature (1998) 2.82
Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres. J Physiol (1976) 2.78
Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644. Proc Natl Acad Sci U S A (1985) 2.73
Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. J Gen Physiol (1975) 2.65
Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. J Biol Chem (2001) 2.64
Rapid reuse of readily releasable pool vesicles at hippocampal synapses. Neuron (2000) 2.59
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology (1993) 2.57
Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature (1989) 2.56
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron (1988) 2.56
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55
Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (1995) 2.46
Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat Neurosci (2001) 2.41
Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current. J Physiol (1969) 2.37
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23
Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers. Science (1968) 2.22
Properties of synaptic transmission at single hippocampal synaptic boutons. Nature (1995) 2.22
Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers. Biophys J (1982) 2.20
Cyclic AMP and contractile activity in heart. Adv Cyclic Nucleotide Res (1977) 2.16
An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i. J Neurosci (1994) 2.15
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion. Proc Natl Acad Sci U S A (2001) 2.14
Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Neuron (1993) 2.14
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology (1997) 2.12
Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers. J Gen Physiol (1974) 2.11
Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? J Physiol (1982) 2.08
Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating. J Gen Physiol (1981) 2.07
Persistent protein kinase activity underlying long-term potentiation. Nature (1988) 2.07
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proc Natl Acad Sci U S A (1988) 2.05
Molecular determinants of voltage-dependent inactivation in calcium channels. Nature (1994) 2.04
Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2001) 2.04
The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres. J Physiol (1969) 2.01
Activity-dependent regulation of synaptic clustering in a hippocampal culture system. Proc Natl Acad Sci U S A (1999) 1.97
Control of action potential duration by calcium ions in cardiac Purkinje fibers. J Gen Physiol (1976) 1.90
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry (1998) 1.89
Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. J Biol Chem (2000) 1.85
Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials. J Gen Physiol (1988) 1.85
Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling. Trends Neurosci (2001) 1.83
Molecular basis of proton block of L-type Ca2+ channels. J Gen Physiol (1996) 1.79
Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'. Nat Neurosci (2000) 1.72
Sodium channels in rabbit cardiac Purkinje fibres. Nature (1979) 1.70
Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating. Science (1986) 1.63
Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. J Neurosci (2000) 1.60
Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery. J Physiol (1988) 1.57
Ca2+-dependent regulation in neuronal gene expression. Curr Opin Neurobiol (1997) 1.56
The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials. J Physiol (1972) 1.56
Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres. Nat New Biol (1973) 1.54
Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins. Neuron (1996) 1.51
Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons. Nature (1987) 1.50
Functional expression of a rapidly inactivating neuronal calcium channel. Nature (1993) 1.48
Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers. Circ Res (1984) 1.46
Role of intracellular calcium in the transient outward current of calf Purkinje fibres. Nature (1977) 1.44
Voltage-gated calcium channels: direct observation of the anomalous mole fraction effect at the single-channel level. Proc Natl Acad Sci U S A (1989) 1.43
Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967). Mol Pharmacol (1995) 1.42
Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus. J Neurosci (1996) 1.41
Is digitalis inotropy associated with enhanced slow inward calcium current? Nature (1978) 1.40
Cellular and subcellular mechanisms of cardiac pacemaker oscillations. J Exp Biol (1979) 1.37