Published in Science on March 28, 1986
Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (1987) 3.69
Calcium and arrhythmogenesis. Physiol Rev (2007) 2.76
Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization. Proc Natl Acad Sci U S A (1987) 2.48
Permeation in the dihydropyridine-sensitive calcium channel. Multi-ion occupancy but no anomalous mole-fraction effect between Ba2+ and Ca2+. J Gen Physiol (1990) 2.06
An intrinsic potential-dependent inactivation mechanism associated with calcium channels in guinea-pig myocytes. J Physiol (1987) 2.04
Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials. J Gen Physiol (1988) 1.85
Mechanisms of permeation and selectivity in calcium channels. Biophys J (2001) 1.79
Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion. J Gen Physiol (1989) 1.72
Monovalent cation conductance in the ryanodine receptor-channel of sheep cardiac muscle sarcoplasmic reticulum. J Physiol (1991) 1.57
Single nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery. Proc Natl Acad Sci U S A (1986) 1.35
Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells. J Physiol (1992) 1.33
Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers. Proc Natl Acad Sci U S A (1988) 1.28
Modulation of slow gating process of calcium channels by isoprenaline in guinea-pig ventricular cells. J Physiol (1990) 1.23
Solubilized proteins from carrot (Daucus carota L.) membranes bind calcium channel blockers and form calcium-permeable ion channels. Proc Natl Acad Sci U S A (1993) 1.13
Heterogeneity of conductance states in calcium channels of skeletal muscle. Biophys J (1988) 1.11
Mechanisms of beta-adrenergic stimulation of cardiac Ca2+ channels revealed by discrete-time Markov analysis of slow gating. Biophys J (1993) 1.11
Characterization and localization of two ion-binding sites within the pore of cardiac L-type calcium channels. J Gen Physiol (1991) 1.11
Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers. Biophys J (1994) 1.10
Dihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. 1. Kinetics and voltage dependence of gating. Biophys J (1991) 1.08
Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation. Biophys J (1987) 0.96
Ontogenesis and localization of Ca2+ channels in mammalian skeletal muscle in culture and role in excitation-contraction coupling. Proc Natl Acad Sci U S A (1989) 0.94
Functional reconstitution of skeletal muscle Ca2+ channels: separation of regulatory and channel components. Proc Natl Acad Sci U S A (1988) 0.90
Opposite effects of phosphatase inhibitors on L-type calcium and delayed rectifier currents in frog cardiac myocytes. J Physiol (1993) 0.90
Internal and external effects of dihydropyridines in the calcium channel of skeletal muscle. J Gen Physiol (1990) 0.89
Monoclonal antibody specific for the transverse tubular membrane of skeletal muscle activates the dihydropyridine-sensitive Ca2+ channel. Proc Natl Acad Sci U S A (1987) 0.82
Simultaneous expression of cardiac and skeletal muscle isoforms of the L-type Ca2+ channel in a rat heart muscle cell line. J Physiol (1994) 0.81
Intervascular and stimulus selectivity of nitrendipine and related derivatives in KCl and prostaglandin F2 alpha precontracted porcine arteries. Br J Pharmacol (1992) 0.79
Evidence for redox sensing by a human cardiac calcium channel. Sci Rep (2016) 0.75
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature (1984) 10.27
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs. Neuron (1992) 10.25
Mechanism of ion permeation through calcium channels. Nature (1984) 9.82
Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature (1985) 9.68
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres. J Physiol (1968) 7.88
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. J Gen Physiol (1986) 6.76
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol (1987) 6.72
Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J Physiol (1969) 6.59
Measurement of Ca2+ concentrations in living cells. Prog Biophys Mol Biol (1982) 6.40
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature (1987) 5.94
Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature (1983) 5.80
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol (1986) 5.38
Calcium channels in excitable cell membranes. Annu Rev Physiol (1983) 5.37
Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature (1999) 5.36
A novel type of cardiac calcium channel in ventricular cells. Nature (1985) 5.33
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature (1993) 5.31
Lidocaine block of cardiac sodium channels. J Gen Physiol (1983) 5.13
Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci (1988) 5.12
Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol (1978) 4.72
Formation and properties of thin-walled phospholipid vesicles. J Cell Physiol (1969) 4.70
Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol (1985) 4.69
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science (1989) 4.48
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science (1994) 4.38
Reconstruction of the electrical activity of cardiac Purkinje fibres. J Physiol (1975) 4.31
CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell (1996) 4.08
Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature (1990) 4.05
Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science (1988) 3.75
Calcium channels: mechanisms of selectivity, permeation, and block. Annu Rev Biophys Biophys Chem (1987) 3.72
Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (1987) 3.69
Single synaptic vesicles fusing transiently and successively without loss of identity. Nature (2003) 3.51
The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron (1993) 3.49
Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron (1989) 3.45
Reversal of current through calcium channels in dialysed single heart cells. Nature (1982) 3.43
Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron (1995) 3.39
Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol (1986) 3.31
Properties of single calcium channels in cardiac cell culture. Nature (1982) 3.30
Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron (1999) 3.29
Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature (1984) 3.24
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature (1999) 3.21
Ionic selectivity, saturation, and block in a K+-selective channel from sarcoplasmic reticulum. J Gen Physiol (1980) 3.16
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature (1998) 3.13
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc Natl Acad Sci U S A (1987) 3.12
High selectivity of calcium channels in single dialysed heart cells of the guinea-pig. J Physiol (1984) 3.12
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci (1995) 3.07
Direct measurement of proton transfer rates to a group controlling the dihydropyridine-sensitive Ca2+ channel. Nature (1987) 3.05
Voltage-sensing residues in the S4 region of a mammalian K+ channel. Nature (1991) 3.01
Calcium-activated transient outward current in calf cardiac Purkinje fibres. J Physiol (1980) 2.95
Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol (1978) 2.94
Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron (1996) 2.86
Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. Nat New Biol (1972) 2.84
A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i. J Physiol (1992) 2.83
Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature (1998) 2.82
Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres. J Physiol (1976) 2.78
Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644. Proc Natl Acad Sci U S A (1985) 2.73
The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci (1997) 2.73
Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. J Gen Physiol (1975) 2.65
Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. J Biol Chem (2001) 2.64
Mechanisms of active transport in isolated bacterial membrane vesicles. 18. The mechanism of action of carbonylcyanide m-chlorophenylhydrazone. Arch Biochem Biophys (1974) 2.61
Evidence for cooperative interactions in potassium channel gating. Nature (1992) 2.61
Rapid reuse of readily releasable pool vesicles at hippocampal synapses. Neuron (2000) 2.59
A G protein directly regulates mammalian cardiac calcium channels. Science (1987) 2.58
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology (1993) 2.57
Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature (1989) 2.56
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron (1988) 2.56
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55
Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (1995) 2.46
Novel mechanism of voltage-dependent gating in L-type calcium channels. Nature (1990) 2.45
Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat Neurosci (2001) 2.41
Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current. J Physiol (1969) 2.37
The stoichiometry of the cardiac sodium-calcium exchange system. J Biol Chem (1984) 2.24
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23
Association of newly synthesized major f1 coat protein with infected host cell inner membrane. J Supramol Struct (1972) 2.22
Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers. Science (1968) 2.22
Properties of synaptic transmission at single hippocampal synaptic boutons. Nature (1995) 2.22
Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron (1990) 2.20
Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers. Biophys J (1982) 2.20
Free magnesium in sheep, ferret and frog striated muscle at rest measured with ion-selective micro-electrodes. J Physiol (1982) 2.17
Cyclic AMP and contractile activity in heart. Adv Cyclic Nucleotide Res (1977) 2.16
An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i. J Neurosci (1994) 2.15
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion. Proc Natl Acad Sci U S A (2001) 2.14
Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Neuron (1993) 2.14
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology (1997) 2.12
Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers. J Gen Physiol (1974) 2.11
Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? J Physiol (1982) 2.08
Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating. J Gen Physiol (1981) 2.07
Persistent protein kinase activity underlying long-term potentiation. Nature (1988) 2.07
Accumulation of amino acids by lysosomes incubated with amino acid methyl esters. J Biol Chem (1979) 2.06
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proc Natl Acad Sci U S A (1988) 2.05
Molecular determinants of voltage-dependent inactivation in calcium channels. Nature (1994) 2.04
Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2001) 2.04