Published in Nature on September 20, 1983
A nuclear gene encoding the beta subunit of the mitochondrial ATP synthase in Nicotiana plumbaginifolia. EMBO J (1985) 4.50
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J (1984) 4.28
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proc Natl Acad Sci U S A (1984) 3.64
The ral gene: a new ras related gene isolated by the use of a synthetic probe. EMBO J (1986) 3.50
Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe. EMBO J (1985) 2.63
Isolation and characterization of the human Gs alpha gene. Proc Natl Acad Sci U S A (1988) 2.55
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.45
Human N-ras: cDNA cloning and gene structure. Nucleic Acids Res (1985) 2.41
A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins. Proc Natl Acad Sci U S A (1986) 2.32
Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene. Mol Cell Biol (1984) 2.24
Role of intron-contained sequences in formation of moloney murine leukemia virus env mRNA. Mol Cell Biol (1984) 2.21
A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein. EMBO J (1988) 2.21
Structure and biological activity of human homologs of the raf/mil oncogene. Mol Cell Biol (1985) 2.19
Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins. Proc Natl Acad Sci U S A (1987) 2.15
The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. EMBO J (1987) 2.14
Nucleotide sequence of two rasH related-genes isolated from the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1984) 2.10
GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.09
Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Br J Cancer (1984) 1.97
A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J (1989) 1.97
Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. Proc Natl Acad Sci U S A (1984) 1.89
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
Purification and characterization of human H-ras proteins expressed in Escherichia coli. Mol Cell Biol (1985) 1.77
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice. Proc Natl Acad Sci U S A (1985) 1.61
Biochemical properties of the ras-related YPT protein in yeast: a mutational analysis. EMBO J (1987) 1.61
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity. EMBO J (1991) 1.49
Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J (1985) 1.46
Characterization and expression of the human rhoH12 gene product. Mol Cell Biol (1989) 1.43
Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors. Proc Natl Acad Sci U S A (1985) 1.43
Structural and functional characterization of the promoter region of the mouse c-Ki-ras gene. Mol Cell Biol (1987) 1.42
Microinjection of ras p21 induces a rapid rise in intracellular pH. Mol Cell Biol (1987) 1.36
Clinical relevance of KRAS in human cancers. J Biomed Biotechnol (2010) 1.34
Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1). Proc Natl Acad Sci U S A (1986) 1.32
Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol Cell Biol (1984) 1.31
Heterologous expression and characterization of the human R-ras gene product. Mol Cell Biol (1987) 1.27
Intron-exon structure of the human transforming growth factor-beta precursor gene. Nucleic Acids Res (1987) 1.25
While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Mol Cell Biol (2003) 1.24
RsaI polymorphism in c-Ki-ras. Nucleic Acids Res (1991) 1.24
RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci U S A (1987) 1.20
One gene and one pseudogene for the cytokeratin endo A. Proc Natl Acad Sci U S A (1985) 1.19
Activation of a human c-K-ras oncogene. Nucleic Acids Res (1984) 1.19
Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor. Nucleic Acids Res (1985) 1.18
Regulated expression of ras gene constructs in Dictyostelium transformants. Proc Natl Acad Sci U S A (1985) 1.16
The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. Mol Cell Biol (1988) 1.16
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer. EMBO J (1984) 1.15
Growing and developing Dictyostelium cells express different ras genes. Proc Natl Acad Sci U S A (1989) 1.12
The predicted DBL oncogene product defines a distinct class of transforming proteins. Proc Natl Acad Sci U S A (1988) 1.12
Isolation and characterization of three distinct cDNAs for the chicken c-ski gene. Mol Cell Biol (1989) 1.09
Feasibility of using decades-old archival tissues in molecular oncology/epidemiology. Am J Pathol (1996) 1.09
Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours. Gut (1995) 1.07
Polylysine-containing peptides, including the carboxyl-terminal segment of the human c-Ki-ras 2 protein, affect the activity of some key membrane enzymes. Proc Natl Acad Sci U S A (1987) 1.03
Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations. PLoS One (2013) 1.00
Identification of the principal promoter sequence of the c-H-ras transforming oncogene: deletion analysis of the 5'-flanking region by focus formation assay. Mol Cell Biol (1987) 1.00
Concurrent mutations in two different ras genes in acute myelocytic leukemias. Nucleic Acids Res (1987) 0.99
Characterization of functional domains of p21 ras by use of chimeric genes. EMBO J (1985) 0.99
Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene. Mol Cell Biol (1986) 0.99
K-ras mutations in patients with early colorectal cancers. Gut (1997) 0.99
Chimeric proteins define variable and essential regions of Ha-ras-encoded protein. Proc Natl Acad Sci U S A (1988) 0.98
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma. Br J Cancer (1997) 0.96
Feedback within the inter-cellular communication and tumorigenesis in carcinomas. PLoS One (2012) 0.95
Activation of Ha-ras p21 by substitution, deletion, and insertion mutations. Mol Cell Biol (1985) 0.95
Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine. Mol Cell Biol (1986) 0.94
Chromatin structure of the promoter region of the human c-K-ras gene. Nucleic Acids Res (1986) 0.93
Amplified DNA in Y1 mouse adrenal tumor cells: isolation of cDNAs complementary to an amplified c-Ki-ras gene and localization of homologous sequences to mouse chromosome 6. Nucleic Acids Res (1984) 0.92
PCR primers to convert c-Ki-ras to a four allele RsaI system (KRAS2). Nucleic Acids Res (1991) 0.89
Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One (2013) 0.89
Structure of the carboxyl terminus of the RAS gene-encoded P21 proteins. Proc Natl Acad Sci U S A (1988) 0.88
Abundant expression of ras proteins in Aplysia neurons. J Cell Biol (1986) 0.88
c-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation. Mol Cell Biol (1989) 0.87
Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J (1993) 0.87
Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae. Mol Cell Biol (1992) 0.85
The BRAF mutation is associated with the prognosis in colorectal cancer. J Cancer Res Clin Oncol (2014) 0.82
Monoclonal antibody specific for an activated RAS protein. Proc Natl Acad Sci U S A (1986) 0.82
The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell. Biochem J (1998) 0.81
The role of cetuximab as first-line treatment of colorectal liver metastases. HPB (Oxford) (2012) 0.81
Kirsten Ras* oncogene: significance of its discovery in human cancer research. Oncotarget (2016) 0.80
Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12. Mol Cell Biol (1984) 0.80
P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state. PLoS One (2009) 0.79
Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer. Cancer Med (2014) 0.78
Single somatic ras gene point mutation in soft tissue malignant fibrous histiocytomas. Am J Pathol (1996) 0.78
Nucleotide sequence of the mouse ypt1 gene encoding a ras-related GTP-binding protein. Nucleic Acids Res (1989) 0.78
High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family. Mamm Genome (1998) 0.76
Internally repeated sequences in ras gene products. Biochem J (1988) 0.75
DNA segment containing C beta 1, a gene for the constant region of the beta chain of the T-cell antigen receptor, was inserted into chromosome 6 in cells from one patient with human T-cell leukemia. Proc Natl Acad Sci U S A (1987) 0.75
Low expression of PKCα and high expression of KRAS predict poor prognosis in patients with colorectal cancer. Oncol Lett (2016) 0.75
Tissue-specific hypomethylation of the human c-K-ras gene. Nucleic Acids Res (1989) 0.75
DdeI polymorphism within sequence encoding 3' untranslated region of c-Ki-ras2 (KRAS2). Nucleic Acids Res (1991) 0.75
Unlike in clear cell renal cell carcinoma, KRAS is not mutated in multilocular cystic clear cell renal cell neoplasm of low potential. Virchows Arch (2015) 0.75
A system for shotgun DNA sequencing. Nucleic Acids Res (1981) 52.99
Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. DNA (1985) 40.01
Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (1989) 16.71
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature (1985) 13.79
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature (1985) 13.04
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. J Virol (1988) 12.52
Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. Nature (1985) 12.08
Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J Clin Microbiol (1999) 11.77
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science (1998) 11.70
Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor. Cell (1987) 11.56
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 11.44
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell (1978) 11.17
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell (1987) 11.15
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (1983) 10.64
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell (1996) 9.68
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science (1985) 9.12
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell (1996) 8.89
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell (1995) 8.80
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (1995) 8.61
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (1986) 7.90
Human serum activities against Hemophilus influenzae, type b. J Clin Invest (1972) 7.85
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
TRAF6 is a signal transducer for interleukin-1. Nature (1996) 7.38
The primary structure and genetic organization of the bovine papillomavirus type 1 genome. Nature (1982) 7.24
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell (1995) 7.18
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature (1990) 7.15
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell (1991) 6.97
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Identification and characterization of an IkappaB kinase. Cell (1997) 6.71
Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature (2000) 6.67
Expression of human immune interferon cDNA in E. coli and monkey cells. Nature (1982) 6.55
Comparative biochemical properties of normal and activated human ras p21 protein. Nature (1984) 6.50
Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (1992) 6.49
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (1995) 6.41
A rapid chemical assay for gentamicin. N Engl J Med (1972) 6.36
Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem (1985) 6.28
Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature (1984) 6.21
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell (1994) 5.94
Human leukocyte interferon produced by E. coli is biologically active. Nature (1980) 5.86
Shuttle mutagenesis: a method of transposon mutagenesis for Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 5.75
Outer membrane protein composition in disease isolates of Haemophilus influenzae: pathogenic and epidemiological implications. Infect Immun (1980) 5.68
RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62
A novel domain within the 55 kd TNF receptor signals cell death. Cell (1993) 5.59
Isolation and expression of an altered mouse dihydrofolate reductase cDNA. Proc Natl Acad Sci U S A (1983) 5.46
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity (1996) 5.45
The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature (1987) 5.43
Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39
Characterization of the human factor VIII gene. Nature (1984) 5.37
Initiation of translation at internal AUG codons in mammalian cells. Nature (1984) 5.34
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science (1998) 5.29
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature (1983) 5.27
Comparison of phenotypic and genotypic techniques for identification of unusual aerobic pathogenic gram-negative bacilli. J Clin Microbiol (1998) 5.27
Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci U S A (1983) 5.25
Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein. Science (1986) 5.25
Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res (1985) 5.22
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity (1994) 5.06
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci (1992) 5.02
Transferable R factors in enteric bacteria causing infection of the genitourinary tract. Lancet (1966) 5.01
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Proc Natl Acad Sci U S A (1980) 4.99
Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature (1984) 4.99
Interaction of RNA polymerase with promoters from bacteriophage fd. Eur J Biochem (1977) 4.94
Haemophilus influenzae meningitis in infant rats after intranasal inoculation. J Infect Dis (1974) 4.94
Two TNF receptors. Immunol Today (1992) 4.87
Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons. Nature (1986) 4.81
Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation. Infect Immun (1973) 4.80
Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A (1979) 4.72
The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science (1988) 4.69
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat Genet (1996) 4.62
R factors mediate resistance to mercury, nickel, and cobalt. Science (1967) 4.57