Published in Proc Natl Acad Sci U S A on February 01, 1992
Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J (1994) 2.95
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med (2002) 2.68
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature (2011) 2.54
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med (1994) 2.26
Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol (1996) 2.17
Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes. J Virol (1993) 1.94
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci U S A (1994) 1.83
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking. Mol Cell Biol (1994) 1.54
Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency. J Virol (1998) 1.52
Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. Proc Natl Acad Sci U S A (1993) 1.49
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A (1994) 1.49
Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. J Exp Med (1994) 1.45
Thy-1 glycoprotein and src-like protein-tyrosine kinase p53/p56lyn are associated in large detergent-resistant complexes in rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1993) 1.45
A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med (1998) 1.43
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J (1994) 1.43
IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J Exp Med (1994) 1.30
Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med (1996) 1.29
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. Proc Natl Acad Sci U S A (1993) 1.27
Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling. J Exp Med (1996) 1.25
c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling. Mol Biol Cell (1997) 1.21
The dynamics of protein kinase B regulation during B cell antigen receptor engagement. J Cell Biol (1999) 1.14
Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. Nat Immunol (2007) 1.14
Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. Proc Natl Acad Sci U S A (1993) 1.12
Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma. Proc Natl Acad Sci U S A (1993) 1.09
RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. J Biol Chem (2009) 1.06
Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO J (1997) 1.02
Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells. Proc Natl Acad Sci U S A (1994) 1.01
Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate. Proc Natl Acad Sci U S A (1995) 1.00
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. J Immunol (1997) 0.99
Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains. Immunology (1996) 0.98
Tyrosine phosphorylation of CD19 in pre-B and mature B cells. EMBO J (1993) 0.97
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Mol Cell (2009) 0.96
Lyn regulates inflammatory responses in Klebsiella pneumoniae infection via the p38/NF-κB pathway. Eur J Immunol (2013) 0.94
Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol Cell Biol (2000) 0.92
Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays. J Exp Med (1992) 0.92
Characterization of the promoter region of the src family gene lyn and its trans activation by human T-cell leukemia virus type I-encoded p40tax. Mol Cell Biol (1992) 0.86
Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. J Exp Med (1996) 0.82
Signal transduction through mu kappa B-cell receptors expressed on pre-B cells is different from that through B-cell receptors on mature B cells. Immunology (1996) 0.77
Functional platelet-derived growth factor-beta (PDGF-beta) receptor expressed on early B-lineage precursor cells. Clin Exp Immunol (1995) 0.75
Evolution of multiple cell clones over a 29-year period of a CLL patient. Nat Commun (2016) 0.75
Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep (2017) 0.75
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Oncogenes and signal transduction. Cell (1991) 14.84
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell (1991) 6.28
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell (1991) 5.65
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci U S A (1990) 5.35
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (1989) 5.20
cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell (1991) 4.76
Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A (1990) 4.32
Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science (1991) 3.86
Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association. Science (1991) 3.84
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A (1991) 3.57
Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell (1991) 3.30
Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med (1982) 3.30
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature (1989) 3.09
Molecular components of the B-cell antigen receptor complex of the IgM class. Nature (1990) 3.06
Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Nature (1990) 3.01
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A (1989) 2.80
Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein. Mol Cell Biol (1985) 2.74
B lymphocyte receptors and polyphosphoinositide degradation. Cell (1985) 2.66
Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin. EMBO J (1990) 2.50
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44
B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J (1990) 2.24
Structure of genes for membrane and secreted murine IgD heavy chains. Nature (1982) 2.15
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature (1991) 2.15
Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc Natl Acad Sci U S A (1991) 2.11
Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. J Biol Chem (1991) 2.00
Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains. Proc Natl Acad Sci U S A (1982) 1.91
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol (1991) 1.84
The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies. J Immunol (1981) 1.83
Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes. Proc Natl Acad Sci U S A (1991) 1.78
Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM. EMBO J (1990) 1.71
IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci U S A (1991) 1.67
Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science (1991) 1.66
Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc Natl Acad Sci U S A (1989) 1.59
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. J Immunol (1987) 1.51
Phosphatidylinositol kinase type I activity associates with various oncogene products. Oncogene Res (1989) 1.48
G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells. J Immunol (1988) 1.45
Membrane IgM, IgD, and IgG act as signal transmission molecules in a series of B lymphomas. J Immunol (1986) 1.34
Requirement of phosphatidylinositol-3 kinase modification for its association with p60src. Mol Cell Biol (1991) 1.33
Receptor signalling and crosstalk in B lymphocytes. Immunol Rev (1987) 1.33
mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain. Proc Natl Acad Sci U S A (1982) 1.28
Increased phosphatidylinositol metabolism is an important but not an obligatory early event in B lymphocyte activation. J Immunol (1985) 1.20
Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation. J Exp Med (1980) 1.16
Co-capping of ras proteins with surface immunoglobulins in B lymphocytes. Nature (1990) 1.12
Alternatively spliced murine lyn mRNAs encode distinct proteins. Mol Cell Biol (1991) 1.06
Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking. J Immunol (1991) 1.01
Involvement of a specific guanine nucleotide binding protein in receptor immunoglobulin stimulated inositol phospholipid hydrolysis. Biochim Biophys Acta (1989) 0.98
Molecular analysis of the dissociation between IL-2 production and proliferation in a response of a T cell clone to the antigen presented by B cells. J Immunol (1988) 0.82
Antiimmunoglobulin inhibition of Burkitt's lymphoma cell proliferation and concurrent reduction of c-myc and mu heavy chain gene expression. Cancer Res (1989) 0.80
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell (1984) 12.54
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (1986) 6.67
Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology (1969) 6.24
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
Human immunodeficiency viruses. Science (1986) 4.34
Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus. Nature (1982) 4.33
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology (2004) 4.24
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell (1984) 4.21
Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature (1992) 3.96
Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet (1986) 3.93
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem (1993) 3.88
Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science (1991) 3.86
The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell (1983) 3.82
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci U S A (1985) 3.80
The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science (1986) 3.74
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells (1999) 3.69
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity. Proc Natl Acad Sci U S A (1980) 3.58
Role of a ras homolog in the life cycle of Schizosaccharomyces pombe. Cell (1986) 3.54
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science (1996) 3.42
Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature (1990) 3.42
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med (2001) 3.40
Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34
Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci U S A (1990) 3.31
Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum Mol Genet (1999) 3.24
yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc Natl Acad Sci U S A (1986) 3.19
A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol (1986) 3.09
Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science (1984) 3.06
Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology (2008) 2.85
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem (1996) 2.85
Purification and properties of the dnaJ replication protein of Escherichia coli. J Biol Chem (1985) 2.84
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene (1997) 2.80
Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage (2002) 2.78
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science (1986) 2.76
CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem (1991) 2.75
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell (1989) 2.73
Temperature sensitive mutants of an avian sarcoma virus. Virology (1969) 2.73
Purification and properties of dextransucrase and invertase from Streptococcus mutans. J Bacteriol (1974) 2.72
Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe. EMBO J (1985) 2.63
Localization of actin and myosin for the study of ameboid movement in Dictyostelium using improved immunofluorescence. J Cell Biol (1984) 2.60
K-ras is essential for the development of the mouse embryo. Oncogene (1997) 2.57
Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57
Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. BJOG (2014) 2.56
Plasma and pituitary concentrations of gonadotropins (FSH and LH) in minke whales (Balaenoptera acutorostrata) during the feeding season. Theriogenology (2001) 2.55
Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci (1997) 2.51
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells (1998) 2.50
Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity (1995) 2.50
Unifected avian cells contain structurally unrelated progenitors of viral sarcoma genes. Nature (1980) 2.50
Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans. J Biol Chem (1984) 2.48
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem (2001) 2.46
Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. J Biol Chem (2001) 2.45
Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA. Proc Natl Acad Sci U S A (1980) 2.45
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44
Expression of functional acetylcholine receptor from cloned cDNAs. Nature (1984) 2.41
Two epidemics of diarrhoeal disease possibly caused by Plesiomonas shigelloides. J Hyg (Lond) (1978) 2.41
Reversible cyclic AMP-dependent change in distribution of myosin thick filaments in Dictyostelium. Nature (1985) 2.40
Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation (1999) 2.40
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37
A case of Trichuris trichiura infection diagnosed by colonoscopy. Am J Gastroenterol (1996) 2.36
Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus. Jpn J Exp Med (1970) 2.35
Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol (1986) 2.33
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci U S A (1996) 2.31
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J Biol Chem (1994) 2.31
Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J Cell Biol (1991) 2.29
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med (1994) 2.26
Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis. Neurology (2006) 2.25
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus. EMBO J (1988) 2.25
Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A (1992) 2.23
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22
Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene (1995) 2.22
Agar-overlay immunofluorescence: high-resolution studies of cytoskeletal components and their changes during chemotaxis. Methods Cell Biol (1987) 2.19
Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene (1986) 2.14
Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Int J Gynecol Cancer (2007) 2.12
Characterization of cDNA clones for the human c-yes gene. Mol Cell Biol (1987) 2.11
Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
Homologous activators of ras in fission and budding yeast. Nature (1990) 2.11
Molecular mechanism of active calcium transport by sarcoplasmic reticulum. Physiol Rev (1978) 2.11
Gastroenteritis due to Kanagawa negative Vibrio parahaemolyticus. Lancet (1987) 2.10
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors. Infect Immun (2000) 2.10
Initial events of myelination involve Fyn tyrosine kinase signalling. Nature (1994) 2.08